Q8R436 · Q8R436_MOUSE
- ProteinGlutathione synthetase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids473 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Pathway
Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 124 | substrate | |||
Binding site | 143 | ATP (UniProtKB | ChEBI) | |||
Binding site | 143 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 145 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 147-150 | substrate | |||
Binding site | 213-215 | substrate | |||
Binding site | 219 | substrate | |||
Binding site | 266-269 | substrate | |||
Binding site | 304 | ATP (UniProtKB | ChEBI) | |||
Binding site | 363-372 | ATP (UniProtKB | ChEBI) | |||
Binding site | 367 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 374 | ATP (UniProtKB | ChEBI) | |||
Binding site | 397-400 | ATP (UniProtKB | ChEBI) | |||
Binding site | 424 | ATP (UniProtKB | ChEBI) | |||
Binding site | 449 | substrate | |||
Binding site | 451 | ATP (UniProtKB | ChEBI) | |||
Binding site | 457 | ATP (UniProtKB | ChEBI) | |||
Binding site | 460-461 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | glutathione synthase activity | |
Molecular Function | metal ion binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlutathione synthetase
- EC number
- Alternative names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8R436
Structure
Sequence
- Sequence statusFragment
- Length473
- Mass (Da)51,945
- Last updated2002-06-01 v1
- Checksum15A46E647316132A
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY079445 EMBL· GenBank· DDBJ | AAL87533.1 EMBL· GenBank· DDBJ | Genomic DNA |