Q8R436 · Q8R436_MOUSE

  • Protein
    Glutathione synthetase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.

Features

Showing features for binding site.

147350100150200250300350400450
TypeIDPosition(s)Description
Binding site124substrate
Binding site143ATP (UniProtKB | ChEBI)
Binding site143Mg2+ (UniProtKB | ChEBI)
Binding site145Mg2+ (UniProtKB | ChEBI)
Binding site147-150substrate
Binding site213-215substrate
Binding site219substrate
Binding site266-269substrate
Binding site304ATP (UniProtKB | ChEBI)
Binding site363-372ATP (UniProtKB | ChEBI)
Binding site367Mg2+ (UniProtKB | ChEBI)
Binding site374ATP (UniProtKB | ChEBI)
Binding site397-400ATP (UniProtKB | ChEBI)
Binding site424ATP (UniProtKB | ChEBI)
Binding site449substrate
Binding site451ATP (UniProtKB | ChEBI)
Binding site457ATP (UniProtKB | ChEBI)
Binding site460-461substrate

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionglutathione synthase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glutathione synthetase
  • EC number
  • Alternative names
    • Glutathione synthase

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • ILS
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8R436

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain203-301Glutathione synthase substrate-binding

Sequence similarities

Belongs to the eukaryotic GSH synthase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    473
  • Mass (Da)
    51,945
  • Last updated
    2002-06-01 v1
  • Checksum
    15A46E647316132A
VPAGAASCRMRSSSKRLAKQAIDRALAEGVLLRSAQHPSSSDVVTYAPFTLFPSPVPSALLEQAYAVQMDFNILVDAVSQNPAFLEQTLSSTIKKDDYTARLFDIYKQVLKEGIAQTVFLGLNRSDYMFQCGADGSKALKQIEINTISASFGGLASRTPAVHRHVLNVLNKTKEASKILSNNPSKGLALGIAKAWELYGSANAVVLLIAQEKERNIFDQRAVENELLDRKIHVIRGRFEDVSERGSLDQNRRLFMDDQEVAVVYFRDGYMPSQYNSQNWEARLMLERSRAAKCPDIAIQLAGTKKVQQELSRVGLLEALLPGQPEAVARLRATFAGLYSLDMGEEGDQAIAEALAAPSHFVLKPQREGGGNNLYGEEMVQALEQLKDSEERASYILMEKIEPEPFRNCLLRPGSPAQVVQCISELGIFGVYVRQGTTLVMNKHVGHLLRTKAVEHADGGVAAGVAVLDNPYPV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY079445
EMBL· GenBank· DDBJ
AAL87533.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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