Q8R3P2 · DTX2_MOUSE
- ProteinProbable E3 ubiquitin-protein ligase DTX2
- GeneDtx2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids619 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity).
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nuclear membrane | |
Cellular Component | nucleoplasm | |
Molecular Function | ubiquitin protein ligase activity | |
Molecular Function | zinc ion binding | |
Biological Process | Notch signaling pathway | |
Biological Process | protein ubiquitination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable E3 ubiquitin-protein ligase DTX2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8R3P2
- Secondary accessions
Proteomes
Organism-specific databases
Phenotypes & Variants
Involvement in disease
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 39 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000219084 | 1-619 | Probable E3 ubiquitin-protein ligase DTX2 | |||
Sequence: MAMAPSSSLPQVYPSHVVVAVWEWQDGLGIWHPYSATVCSFIEQHFVRQRGQHFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQNTGTMRSVRRHLFSQNSAPGQGIVWEWLGDDGSWVAYEARICDYLEQQVARGIQVVDLAPLGYNYTVNYATLTQTNKTSSFCRSVRRQVGPVYPVTSDIAVPRQMGLICFCQQCLHGSGTGPVSGRYRHSMTNLPAYPAPQAPHRTTTVSGAHQAFAPYNKPSLSGARSAPRLNTTNPWAAAPPVAGNQSLFHSSLSHLGPQLLPSGPSTSSGASASFPSGPSSSSPGSAPTTVPVQMPKASRVQQALAGMTSVLSAIGLPVCLSRAPRPTGPPASRPASKSHSSVKRLRKMSVKEGAPKPEPEQVIRKYTEELKVAPEEDCIICMEKLAVASGYSDMTDSKALGPMVVGRLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPWGKMEVFRFQMSLPGHEDCGTILIVYNIPHGIQGPEHPSPGKPFTARGFPRQCYLPDSPQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNVTGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ | ||||||
Modified residue | 213 | Asymmetric dimethylarginine | ||||
Sequence: R | ||||||
Modified residue | 215 | Asymmetric dimethylarginine | ||||
Sequence: R | ||||||
Modified residue | 232 | Asymmetric dimethylarginine | ||||
Sequence: R | ||||||
Modified residue | 248 | N6-acetyllysine | ||||
Sequence: K | ||||||
Modified residue | 255 | Omega-N-methylarginine | ||||
Sequence: R |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in testis and the CNS.
Developmental stage
In the CNS, it is expressed in the developing neural tube starting from 10.5 dpc in the spinal cord and around 11.5 dpc in the telencephalon. Expressed ubiquitously throughout the spinal cord and telencephalon during neurogenesis. Expressed throughout the developing retina at 15.5 dpc. Not expressed in the somite or presomite during somitogenesis. Expressed slightly earlier that Dtx1 and Dtx3.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-97 | WWE 1 | ||||
Sequence: SSLPQVYPSHVVVAVWEWQDGLGIWHPYSATVCSFIEQHFVRQRGQHFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQNTGTMRSVRR | ||||||
Domain | 98-174 | WWE 2 | ||||
Sequence: HLFSQNSAPGQGIVWEWLGDDGSWVAYEARICDYLEQQVARGIQVVDLAPLGYNYTVNYATLTQTNKTSSFCRSVRR | ||||||
Region | 243-271 | Disordered | ||||
Sequence: FAPYNKPSLSGARSAPRLNTTNPWAAAPP | ||||||
Region | 283-328 | Disordered | ||||
Sequence: LSHLGPQLLPSGPSTSSGASASFPSGPSSSSPGSAPTTVPVQMPKA | ||||||
Region | 355-389 | Disordered | ||||
Sequence: PRPTGPPASRPASKSHSSVKRLRKMSVKEGAPKPE | ||||||
Zinc finger | 409-470 | RING-type | ||||
Sequence: CIICMEKLAVASGYSDMTDSKALGPMVVGRLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCK |
Domain
The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.
Sequence similarities
Belongs to the Deltex family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q8R3P2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length619
- Mass (Da)67,195
- Last updated2003-09-26 v2
- ChecksumA3A9F16F5B855697
Q8R3P2-2
- Name2
- SynonymsDeltaE
- Differences from canonical
- 337-382: Missing
Q8R3P2-3
- Name3
- NoteSplicing donor site not canonical.
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0R4IZY1 | A0A0R4IZY1_MOUSE | Dtx2 | 618 | ||
A0A1C7ZMZ6 | A0A1C7ZMZ6_MOUSE | Dtx2 | 8 | ||
A0A0G2JDR7 | A0A0G2JDR7_MOUSE | Dtx2 | 151 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_008351 | 337-382 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_008352 | 338-357 | in isoform 3 | |||
Sequence: MTSVLSAIGLPVCLSRAPRP → EDRRVYWLLVLYSGYRELDN | ||||||
Alternative sequence | VSP_008353 | 358-619 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 383 | in Ref. 1; BAB18940 | ||||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB015423 EMBL· GenBank· DDBJ | BAB18940.1 EMBL· GenBank· DDBJ | mRNA | ||
AB015424 EMBL· GenBank· DDBJ | BAB18941.1 EMBL· GenBank· DDBJ | mRNA | ||
AK012137 EMBL· GenBank· DDBJ | BAB28055.1 EMBL· GenBank· DDBJ | mRNA | ||
AK044105 EMBL· GenBank· DDBJ | BAC31780.1 EMBL· GenBank· DDBJ | mRNA | ||
AK054443 EMBL· GenBank· DDBJ | BAC35781.1 EMBL· GenBank· DDBJ | mRNA | ||
BC024925 EMBL· GenBank· DDBJ | AAH24925.1 EMBL· GenBank· DDBJ | mRNA |