Q8R368 · DAAF4_MOUSE
- ProteinDynein axonemal assembly factor 4
- GeneDnaaf4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids420 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity (By similarity).
Axonemal dynein assembly factor required for ciliary motility
Axonemal dynein assembly factor required for ciliary motility
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | centrosome | |
Cellular Component | cytoplasm | |
Cellular Component | cytosol | |
Cellular Component | dynein axonemal particle | |
Cellular Component | extracellular region | |
Cellular Component | neuron projection | |
Cellular Component | non-motile cilium | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | nuclear estrogen receptor binding | |
Biological Process | cilium movement | |
Biological Process | determination of left/right symmetry | |
Biological Process | epithelial cilium movement involved in extracellular fluid movement | |
Biological Process | establishment of localization in cell | |
Biological Process | heart development | |
Biological Process | inner dynein arm assembly | |
Biological Process | learning or memory | |
Biological Process | neuron migration | |
Biological Process | outer dynein arm assembly | |
Biological Process | regulation of intracellular estrogen receptor signaling pathway | |
Biological Process | regulation of proteasomal protein catabolic process |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameDynein axonemal assembly factor 4
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8R368
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000106285 | 1-420 | Dynein axonemal assembly factor 4 | |||
Sequence: MPVRVSEFSWQQTPATIFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFELFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWDSLSVPGVDKEMMQRIREKSILQAQEKAKEATEAKAVAKREDQRYALGEMMKIEEEERKKIEDMKENERKKATSELEAWKECQKKADGQKRVQRKEKPLEGKQAEETKALKPRGLPRKAPPTRLPTRGRNWENIFPEKLKEDRVPAPRSAGSIQISFTPRVFPTALRESQVAEEEEWLHKQAEARRAMSTDLPEFFDLKEEERNPDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKIPLLYLNRAACHLKLKNLHKAIEDSSKALELLTPPVADNANARMKAHVRRGTAFCQLELYVEGLQDYEAALKIDPANTVVQNDAEKIRNIIQGTALKSRD |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with ZMYND10 (By similarity).
Interacts with ESR1 and ESR2. Interacts with STUB1 (By similarity).
Interacts with DNAAF2 (By similarity).
Interacts with CCT3, CCT4, CCT5 and CCT8 (PubMed:23872636).
Interacts with DNAAF6/PIH1D3 (By similarity).
Interacts with ESR1 and ESR2. Interacts with STUB1 (By similarity).
Interacts with DNAAF2 (By similarity).
Interacts with CCT3, CCT4, CCT5 and CCT8 (PubMed:23872636).
Interacts with DNAAF6/PIH1D3 (By similarity).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-87 | CS | ||||
Sequence: VRVSEFSWQQTPATIFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFELFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWDSLS | ||||||
Region | 7-103 | Mediates interaction with ESR1 and STUB1 | ||||
Sequence: EFSWQQTPATIFLSLPLRGVCVRDADVFCGESYLKVNFPPFLFELFLYAPIDDGKSKAKIGNDTILFTLYKKEPVLWDSLSVPGVDKEMMQRIREKS | ||||||
Compositional bias | 164-196 | Basic and acidic residues | ||||
Sequence: ECQKKADGQKRVQRKEKPLEGKQAEETKALKPR | ||||||
Region | 164-212 | Disordered | ||||
Sequence: ECQKKADGQKRVQRKEKPLEGKQAEETKALKPRGLPRKAPPTRLPTRGR | ||||||
Repeat | 288-321 | TPR 1 | ||||
Sequence: PDWLKDKGNKLFATENYLAAVDAYNLAIRLNCKI | ||||||
Repeat | 322-355 | TPR 2 | ||||
Sequence: PLLYLNRAACHLKLKNLHKAIEDSSKALELLTPP | ||||||
Repeat | 364-397 | TPR 3 | ||||
Sequence: MKAHVRRGTAFCQLELYVEGLQDYEAALKIDPAN |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length420
- Mass (Da)48,125
- Last updated2012-10-03 v2
- ChecksumD49B9A9D84B82325
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E9Q973 | E9Q973_MOUSE | Dnaaf4 | 300 |
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 88 | in Ref. 3; AAH26462 | ||||
Sequence: V → M | ||||||
Compositional bias | 164-196 | Basic and acidic residues | ||||
Sequence: ECQKKADGQKRVQRKEKPLEGKQAEETKALKPR | ||||||
Sequence conflict | 182-184 | in Ref. 3; AAH26462 | ||||
Sequence: LEG → PER |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC158997 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH466522 EMBL· GenBank· DDBJ | EDL26272.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC026462 EMBL· GenBank· DDBJ | AAH26462.1 EMBL· GenBank· DDBJ | mRNA |