We concluded that pro-apoptotic effects on Th1 population through galectin-9-Tim-3 pathway and the up-regulation of Tim-2 on Th2 cells might be critical to Th2-biased response of host with schistosomiasis japonica.
The increased expression of the pro-inflammatory and proapoptotic genes a higher number of apoptotic cells and increased injury and mortality of the TIM2-deficient mice suggest a protective role of TIM2 in cisplatin-induced nephrotoxicity.
There are Tim2-binding molecules on hepatocytes. Tim2-hFc inhibited differentiation & proliferation of hepatocytes in fetal liver primary culture. Down-regulation of Tim2 expression by siRNA enhanced expression of liver differentiation marker genes.
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