Q8R183 · TIMD2_MOUSE
- ProteinT-cell immunoglobulin and mucin domain-containing protein 2
- GeneTimd2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids305 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed:16203866, PubMed:33065090).
Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823).
Plays also an important role in the regulation of Th2 immunity (PubMed:16043519).
Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982).
Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823).
Plays also an important role in the regulation of Th2 immunity (PubMed:16043519).
Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982).
Miscellaneous
Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma. The human genomic locus appears to lack the Timd2 gene.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | plasma membrane | |
Molecular Function | ferritin receptor activity | |
Molecular Function | phosphatidylserine binding | |
Molecular Function | virus receptor activity | |
Biological Process | iron ion transport | |
Biological Process | phagocytosis, engulfment | |
Biological Process | positive regulation of mast cell activation |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameT-cell immunoglobulin and mucin domain-containing protein 2
- Short namesTIMD-2
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8R183
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 22-231 | Extracellular | ||||
Sequence: HTAVQGLAGHPVTLPCIYSTHLGGIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSLYQLKGNISEGNVSLTIENTVVGDGGPYCCVVEIPGAFHFVDYMLEVKPEISTSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETYKPEATTFYPDQTTAEVTETLPDTPADWHNTVTSSDDPWDDNTEVIPPQKPQKNLNKG | ||||||
Transmembrane | 232-252 | Helical | ||||
Sequence: FYVGISIAALLILMLLSTMVI | ||||||
Topological domain | 253-305 | Cytoplasmic | ||||
Sequence: TRYVVMKRKSESLSFVAFPISKIGASPKKVVERTRCEDQVYIIEDTPYPEEES |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Deletion mutants lead to ferritin accumulation and iron overload in the retina leading to retinal lesions.
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MNQIQVFISGLILLLPGAVES | ||||||
Chain | PRO_0000042099 | 22-305 | T-cell immunoglobulin and mucin domain-containing protein 2 | |||
Sequence: HTAVQGLAGHPVTLPCIYSTHLGGIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSLYQLKGNISEGNVSLTIENTVVGDGGPYCCVVEIPGAFHFVDYMLEVKPEISTSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETYKPEATTFYPDQTTAEVTETLPDTPADWHNTVTSSDDPWDDNTEVIPPQKPQKNLNKGFYVGISIAALLILMLLSTMVITRYVVMKRKSESLSFVAFPISKIGASPKKVVERTRCEDQVYIIEDTPYPEEES | ||||||
Disulfide bond | 37↔109 | |||||
Sequence: CIYSTHLGGIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSLYQLKGNISEGNVSLTIENTVVGDGGPYCC | ||||||
Disulfide bond | 50↔61 | |||||
Sequence: CWGLGECRHSYC | ||||||
Disulfide bond | 56↔108 | |||||
Sequence: CRHSYCIRSLIWTNGYTVTHQRNSLYQLKGNISEGNVSLTIENTVVGDGGPYC | ||||||
Glycosylation | 86 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 91 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed on late differentiated Th2 cells (PubMed:16043519).
Expressed also on all splenic B-cells, with increased levels on germinal center B-cells, in the liver, especially in bile duct epithelial cells, and in renal tubule cells (PubMed:16203866).
Within retina, mainly expressed in Mueller cells (PubMed:33065090).
Expressed also on all splenic B-cells, with increased levels on germinal center B-cells, in the liver, especially in bile duct epithelial cells, and in renal tubule cells (PubMed:16203866).
Within retina, mainly expressed in Mueller cells (PubMed:33065090).
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 22-125 | Ig-like V-type | ||||
Sequence: HTAVQGLAGHPVTLPCIYSTHLGGIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSLYQLKGNISEGNVSLTIENTVVGDGGPYCCVVEIPGAFHFVDYMLE | ||||||
Region | 130-174 | Disordered | ||||
Sequence: ISTSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETY | ||||||
Compositional bias | 132-174 | Polar residues | ||||
Sequence: TSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETY |
Sequence similarities
Belongs to the immunoglobulin superfamily. TIM family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length305
- Mass (Da)33,504
- Last updated2002-06-01 v1
- Checksum4105D75D99F541AB
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 80 | in Ref. 1; AAL35772/AAL35773 | ||||
Sequence: L → R | ||||||
Compositional bias | 132-174 | Polar residues | ||||
Sequence: TSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETY | ||||||
Sequence conflict | 196 | in Ref. 1; AAL35772/AAL35773 | ||||
Sequence: D → S |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF399827 EMBL· GenBank· DDBJ | AAL35772.1 EMBL· GenBank· DDBJ | mRNA | ||
AF399828 EMBL· GenBank· DDBJ | AAL35773.1 EMBL· GenBank· DDBJ | mRNA | ||
BC025096 EMBL· GenBank· DDBJ | AAH25096.1 EMBL· GenBank· DDBJ | mRNA |