Q8R183 · TIMD2_MOUSE

  • Protein
    T-cell immunoglobulin and mucin domain-containing protein 2
  • Gene
    Timd2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed:16203866, PubMed:33065090).
Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823).
Plays also an important role in the regulation of Th2 immunity (PubMed:16043519).
Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982).

Miscellaneous

Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma. The human genomic locus appears to lack the Timd2 gene.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentplasma membrane
Molecular Functionferritin receptor activity
Molecular Functionphosphatidylserine binding
Molecular Functionvirus receptor activity
Biological Processiron ion transport
Biological Processphagocytosis, engulfment
Biological Processpositive regulation of mast cell activation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    T-cell immunoglobulin and mucin domain-containing protein 2
  • Short names
    TIMD-2
  • Alternative names
    • T-cell immunoglobulin mucin receptor 2 (TIM-2)
    • T-cell membrane protein 2

Gene names

    • Name
      Timd2
    • Synonyms
      Tim2

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • DBA/2J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8R183
  • Secondary accessions
    • Q8VBW0

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain22-231Extracellular
Transmembrane232-252Helical
Topological domain253-305Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Deletion mutants lead to ferritin accumulation and iron overload in the retina leading to retinal lesions.

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000004209922-305T-cell immunoglobulin and mucin domain-containing protein 2
Disulfide bond37↔109
Disulfide bond50↔61
Disulfide bond56↔108
Glycosylation86N-linked (GlcNAc...) asparagine
Glycosylation91N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed on late differentiated Th2 cells (PubMed:16043519).
Expressed also on all splenic B-cells, with increased levels on germinal center B-cells, in the liver, especially in bile duct epithelial cells, and in renal tubule cells (PubMed:16203866).
Within retina, mainly expressed in Mueller cells (PubMed:33065090).

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain22-125Ig-like V-type
Region130-174Disordered
Compositional bias132-174Polar residues

Sequence similarities

Belongs to the immunoglobulin superfamily. TIM family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    305
  • Mass (Da)
    33,504
  • Last updated
    2002-06-01 v1
  • Checksum
    4105D75D99F541AB
MNQIQVFISGLILLLPGAVESHTAVQGLAGHPVTLPCIYSTHLGGIVPMCWGLGECRHSYCIRSLIWTNGYTVTHQRNSLYQLKGNISEGNVSLTIENTVVGDGGPYCCVVEIPGAFHFVDYMLEVKPEISTSPPTRPTATGRPTTISTRSTHVPTSTRVSTSTSPTPAHTETYKPEATTFYPDQTTAEVTETLPDTPADWHNTVTSSDDPWDDNTEVIPPQKPQKNLNKGFYVGISIAALLILMLLSTMVITRYVVMKRKSESLSFVAFPISKIGASPKKVVERTRCEDQVYIIEDTPYPEEES

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A8C1R4A8C1R4_MOUSETimd2305
D3YUN5D3YUN5_MOUSETimd292

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict80in Ref. 1; AAL35772/AAL35773
Compositional bias132-174Polar residues
Sequence conflict196in Ref. 1; AAL35772/AAL35773

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF399827
EMBL· GenBank· DDBJ
AAL35772.1
EMBL· GenBank· DDBJ
mRNA
AF399828
EMBL· GenBank· DDBJ
AAL35773.1
EMBL· GenBank· DDBJ
mRNA
BC025096
EMBL· GenBank· DDBJ
AAH25096.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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