Q8R0S4 · CACB4_MOUSE

  • Protein
    Voltage-dependent L-type calcium channel subunit beta-4
  • Gene
    Cacnb4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentglutamatergic synapse
Cellular Componentnuclear speck
Cellular Componentplasma membrane
Cellular Componentpresynapse
Cellular Componentvoltage-gated calcium channel complex
Molecular Functionhigh voltage-gated calcium channel activity
Molecular Functionprotein kinase binding
Molecular Functionvoltage-gated calcium channel activity
Molecular Functionvoltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels
Biological Processadult walking behavior
Biological Processcalcium ion transport
Biological ProcesscAMP metabolic process
Biological Processcellular response to leukemia inhibitory factor
Biological Processchemical synaptic transmission
Biological Processdetection of light stimulus involved in visual perception
Biological Processgamma-aminobutyric acid secretion
Biological Processgamma-aminobutyric acid signaling pathway
Biological Processmuscle cell development
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of G1/S transition of mitotic cell cycle
Biological Processnervous system process
Biological Processneuromuscular junction development
Biological Processneuronal action potential propagation
Biological ProcessPeyer's patch development
Biological Processpositive regulation of protein localization to nucleolus
Biological Processregulation of membrane potential
Biological Processregulation of synaptic vesicle exocytosis
Biological Processspleen development
Biological Processsynaptic transmission, glutamatergic
Biological ProcessT cell receptor signaling pathway
Biological Processthymus development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent L-type calcium channel subunit beta-4
  • Short names
    CAB4
  • Alternative names
    • Calcium channel voltage-dependent subunit beta 4

Gene names

    • Name
      Cacnb4
    • Synonyms
      Cacnlb4

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8R0S4
  • Secondary accessions
    • Q3UHK2
    • Q8BRN6
    • Q8CAJ9

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001440611-519Voltage-dependent L-type calcium channel subunit beta-4
Modified residue38Phosphoserine
Modified residue182Phosphoserine
Modified residue410Phosphothreonine
Modified residue447Phosphoserine
Modified residue505Omega-N-methylarginine
Modified residue507Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

The L-type calcium channel is composed of four subunits: alpha-1, alpha-2, beta and gamma. Interacts with FASLG (By similarity).
Interacts with CBARP (PubMed:24751537).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
XENO Q8R0S4ERC1 Q8IUD2-22EBI-3647752, EBI-6920871
BINARY Q8R0S4Ppp2r5d Q91V892EBI-3647752, EBI-8028449

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias1-26Polar residues
Region1-70Disordered
Compositional bias36-60Polar residues
Domain91-160SH3
Region165-185Disordered
Compositional bias424-454Polar residues
Region424-519Disordered
Compositional bias455-500Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q8R0S4-3

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    519
  • Mass (Da)
    57,950
  • Last updated
    2007-01-23 v2
  • Checksum
    663A88C7BCF7E90C
MSSSYGKNGAADGPHSPSSQVARGTTTRRSRLKRSDGSTTSTSFILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHGGKSSGNSSSSLGEMVSGTFRATPTTTAKQKQKVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLAEVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTSSSTPMTPLLGRNVGSTALSPYPTAISGLQSQRMRHSNHSTENSPIERRSLMTSDENYHNERARKSRNRLSSSSQHSRDHYPLVEEDYPDSYQDTYKPHRNRGSPGGCSHDSRHRL

Q8R0S4-1

  • Name
    1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-48: MSSSYGKNGAADGPHSPSSQVARGTTTRRSRLKRSDGSTTSTSFILRQ → MYDNLYLHGVEDSEA

Q8R0S4-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-48: MSSSYGKNGAADGPHSPSSQVARGTTTRRSRLKRSDGSTTSTSFILRQ → MA

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-26Polar residues
Alternative sequenceVSP_0225991-48in isoform 1
Alternative sequenceVSP_0107371-48in isoform 2
Compositional bias36-60Polar residues
Compositional bias424-454Polar residues
Compositional bias455-500Basic and acidic residues
Sequence conflict492in Ref. 2; BAC31681

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB100402
EMBL· GenBank· DDBJ
BAC80139.1
EMBL· GenBank· DDBJ
Genomic DNA
AK038633
EMBL· GenBank· DDBJ
BAC30073.1
EMBL· GenBank· DDBJ
mRNA
AK043850
EMBL· GenBank· DDBJ
BAC31681.1
EMBL· GenBank· DDBJ
mRNA
AK079616
EMBL· GenBank· DDBJ
BAC37703.1
EMBL· GenBank· DDBJ
mRNA
AK147338
EMBL· GenBank· DDBJ
BAE27855.1
EMBL· GenBank· DDBJ
mRNA
BC026479
EMBL· GenBank· DDBJ
AAH26479.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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