Q8QMW9 · Q8QMW9_CWPXB

Function

function

Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase OPG063 that creates mRNA's poly(A) tail. In the presence of OPG102, OPG063 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site22mRNA (UniProtKB | ChEBI)
Binding site39S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site66S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site68S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site72S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site95S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site97S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site116S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site138S-adenosyl-L-methionine (UniProtKB | ChEBI)
Active site175For methyltransferase activity
Binding site177-180mRNA (UniProtKB | ChEBI)
Binding site182mRNA (UniProtKB | ChEBI)
Binding site205-207mRNA (UniProtKB | ChEBI)
Binding site233mRNA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionmRNA (nucleoside-2'-O-)-methyltransferase activity
Molecular Functiontranslation elongation factor activity
Biological Process7-methylguanosine mRNA capping
Biological Processmethylation
Biological Processregulation of mRNA 3'-end processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
  • EC number

Gene names

    • Name
      CPXV106 CDS

Organism names

Accessions

  • Primary accession
    Q8QMW9

Proteomes

Subcellular Location

Virion

Keywords

  • Cellular component

Interaction

Subunit

Interacts with poly(A) polymerase catalytic subunit OPG063. Interacts with OPG109 and OPG123; these interactions might help linking transcription to capping and polyadenylation.

Family & Domains

Features

Showing features for compositional bias, region.

Type
IDPosition(s)Description
Compositional bias305-324Basic and acidic residues
Region305-333Disordered

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    333
  • Mass (Da)
    38,841
  • Last updated
    2002-06-01 v1
  • Checksum
    6AAF96186F895261
MDVVSLDKPFMYFEEIDNELDYEPESANEVAKKLPYQGQLKLLLGELFFLSKLQRHGILDGATVVYIGSAPGTHIRYLRDHFYNLGVIIKWMLIDGRHHDPILNGLRDVTLVTRFVDEEYLRTIKKQLHPSKIILISDVRSKRGGNEPSTADLLSNYALQNVMISILNPVASSLKWRCPFPDQWIKDFYIPHGNKMLQPFAPSYSAEMRLLSIYTGENMRLTRVTKSDAVNYEKKMYYLNKIVRNKVVVNFDYPNQEYDYFHMYFMLRTVYCNKTFPTTKAKVLFLQQSIFRFLNIPTTSTEKVSHEPIQRKISSKDSVSKNRNSKRSVRGNK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias305-324Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF482758
EMBL· GenBank· DDBJ
AAM13549.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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