Q8QGH2 · SUMO1_CHICK
- ProteinSmall ubiquitin-related modifier 1
- GeneSUMO1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids101 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nuclear membrane | |
Cellular Component | nuclear speck | |
Cellular Component | nuclear stress granule | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Cellular Component | PML body | |
Molecular Function | protein tag activity | |
Molecular Function | transcription factor binding | |
Molecular Function | ubiquitin-like protein ligase binding | |
Biological Process | cellular response to cadmium ion | |
Biological Process | cellular response to heat | |
Biological Process | protein sumoylation |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSmall ubiquitin-related modifier 1
- Short namesSUMO-1
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionQ8QGH2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, cross-link, propeptide.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000267614 | 1-97 | Small ubiquitin-related modifier 1 | ||
Cross-link | 97 | Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) | |||
Propeptide | PRO_0000267615 | 98-101 | |||
Post-translational modification
Cleavage of precursor form by a sentrin-specific protease is necessary for function.
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2 (By similarity).
Covalently attached to a number of proteins (By similarity).
Covalently attached to a number of proteins (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 20-97 | Ubiquitin-like | |||
Sequence similarities
Belongs to the ubiquitin family. SUMO subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length101
- Mass (Da)11,557
- Last updated2002-06-01 v1
- Checksum9415E7C69554FB33
Computationally mapped potential isoform sequences
There are 8 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8V0ZWF3 | A0A8V0ZWF3_CHICK | SUMO1 | 76 | ||
A0A8V0ZWF7 | A0A8V0ZWF7_CHICK | SUMO1 | 170 | ||
A0A8V1A3X9 | A0A8V1A3X9_CHICK | SUMO1 | 75 | ||
A0A8V1A1M4 | A0A8V1A1M4_CHICK | SUMO1 | 129 | ||
A0A8V1A1L9 | A0A8V1A1L9_CHICK | SUMO1 | 138 | ||
A0A8V1A945 | A0A8V1A945_CHICK | SUMO1 | 95 | ||
A0A8V1A956 | A0A8V1A956_CHICK | SUMO1 | 117 | ||
A0A8V1A678 | A0A8V1A678_CHICK | SUMO1 | 112 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF461015 EMBL· GenBank· DDBJ | AAL85281.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ719470 EMBL· GenBank· DDBJ | CAG31129.1 EMBL· GenBank· DDBJ | mRNA |