Q8QGH2 · SUMO1_CHICK

  • Protein
    Small ubiquitin-related modifier 1
  • Gene
    SUMO1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnuclear membrane
Cellular Componentnuclear speck
Cellular Componentnuclear stress granule
Cellular Componentnucleus
Cellular Componentplasma membrane
Cellular ComponentPML body
Molecular Functionprotein tag activity
Molecular Functiontranscription factor binding
Molecular Functionubiquitin-like protein ligase binding
Biological Processcellular response to cadmium ion
Biological Processcellular response to heat
Biological Processprotein sumoylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Small ubiquitin-related modifier 1
  • Short names
    SUMO-1

Gene names

    • Name
      SUMO1
    • ORF names
      RCJMB04_2j18

Organism names

  • Taxonomic identifier
  • Strain
    • CB
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus

Accessions

  • Primary accession
    Q8QGH2

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain, cross-link, propeptide.

Type
IDPosition(s)Description
ChainPRO_00002676141-97Small ubiquitin-related modifier 1
Cross-link97Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
PropeptidePRO_000026761598-101

Post-translational modification

Cleavage of precursor form by a sentrin-specific protease is necessary for function.

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with SAE2, UBE2I, RANBP2, PIAS1 and PIAS2 (By similarity).
Covalently attached to a number of proteins (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-97Ubiquitin-like

Sequence similarities

Belongs to the ubiquitin family. SUMO subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    101
  • Mass (Da)
    11,557
  • Last updated
    2002-06-01 v1
  • Checksum
    9415E7C69554FB33
MSDQEAKPSAEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRITDNHTPKELGMEEEDVIEVYQEQTGGHSTV

Computationally mapped potential isoform sequences

There are 8 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8V0ZWF3A0A8V0ZWF3_CHICKSUMO176
A0A8V0ZWF7A0A8V0ZWF7_CHICKSUMO1170
A0A8V1A3X9A0A8V1A3X9_CHICKSUMO175
A0A8V1A1M4A0A8V1A1M4_CHICKSUMO1129
A0A8V1A1L9A0A8V1A1L9_CHICKSUMO1138
A0A8V1A945A0A8V1A945_CHICKSUMO195
A0A8V1A956A0A8V1A956_CHICKSUMO1117
A0A8V1A678A0A8V1A678_CHICKSUMO1112

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF461015
EMBL· GenBank· DDBJ
AAL85281.1
EMBL· GenBank· DDBJ
mRNA
AJ719470
EMBL· GenBank· DDBJ
CAG31129.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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