Q8PVZ4 · PRIS_METMA

Function

function

Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site.

141450100150200250300350400
TypeIDPosition(s)Description
Active site98
Active site100
Active site312

GO annotations

AspectTerm
Cellular ComponentDNA-directed RNA polymerase complex
Cellular Componentprimosome complex
Molecular FunctionDNA primase activity
Molecular Functionmetal ion binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA primase small subunit PriS
  • EC number

Gene names

    • Name
      priS
    • Synonyms
      priA
    • Ordered locus names
      MM_1811

Organism names

Accessions

  • Primary accession
    Q8PVZ4

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000467441-414DNA primase small subunit PriS

Interaction

Subunit

Heterodimer of a small subunit (PriS) and a large subunit (PriL).

Structure

Family & Domains

Sequence similarities

Belongs to the eukaryotic-type primase small subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    414
  • Mass (Da)
    47,502
  • Last updated
    2002-10-01 v1
  • Checksum
    BE30EDAE66364E1D
MDSRTTRYLKSCFQKHYKTAEIGLPDHLPNREWAFIFYDDMPEKMMHRHKSFGSPGEALDYLYGMAPAHVYNSTAYYEYPDARKMNEKNWLGAELIFDLDADHLPNAPRNYADMLELVKKETLKLMDFLLDDFGFSEQDIELVFSGGRGYHFHITSPKVLTLGSSERREIVNYLSGRDIDFKYFFREVSMDGDFGTGSKSFKGIKNLPVKCTLVGYDSGWGKRVALYLTDYMKAECGKKYKKDMFPELRRHEKVGDTTIKKLINITNSENGLKDILERGRLDFGVRNFKEIAAYFMQESMENFLNRFGASVDEPVTADIKRLIRVPGSLHGGSGMLVKKLALCELEKFNPLNDAVVFGERPVKITVSKPFSVQLKGKDLRIEEGIQEVPEYAAVYLICRGVAEYGYRRNQPDAV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE008384
EMBL· GenBank· DDBJ
AAM31507.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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