Q8PSD1 · Q8PSD1_METMA

Function

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.

Features

Showing features for binding site, active site, site.

125820406080100120140160180200220240
TypeIDPosition(s)Description
Binding site11Mg2+ 1 (UniProtKB | ChEBI)
Binding site13Mg2+ (UniProtKB | ChEBI)
Binding site39Mg2+ 1 (UniProtKB | ChEBI)
Binding site39Mg2+ (UniProtKB | ChEBI)
Active site112
Active site152Proton donor/acceptor
Binding site152Mg2+ 1 (UniProtKB | ChEBI)
Binding site154Mg2+ 1 (UniProtKB | ChEBI)
Site154Transition state stabilizer
Site223Important for catalytic activity
Binding site248Mg2+ 1 (UniProtKB | ChEBI)
Active site249Proton acceptor
Binding site249Mg2+ 1 (UniProtKB | ChEBI)
Site249Interaction with DNA substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Molecular Functionphosphoric diester hydrolase activity
Biological Processbase-excision repair

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Exodeoxyribonuclease III
      (EC:3.1.11.2
      )

Gene names

    • Ordered locus names
      MM_3148

Organism names

Accessions

  • Primary accession
    Q8PSD1

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-249Endonuclease/exonuclease/phosphatase

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    258
  • Mass (Da)
    29,747
  • Last updated
    2002-10-01 v1
  • Checksum
    DB14843F5BF12927
MPEHYNLISWNVNGLRAAVKKGFLDLLLEHRFDIVCVQETKVSQDKLPREVKNIQGYYNYFVSAEQNGYSGVGTFSKNKPIKLEKGMGIEVFDREGRFLRTDYEDFVLLNIYFPNGKASQERLGYKMAFYDAFLDYANALKSEGKKLVICGDVNTAHKEIDLARPKQNEMISGFLPEERAWMDKFLAAGYLDSFRMFNPEGGNYSWWSMRTGARSRNVGWRLDYVFVSENLRENVKSASIYPEIMGSDHCPVGLELEF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE008384
EMBL· GenBank· DDBJ
AAM32844.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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