Q8PHC8 · CYSI_XANAC
- ProteinSulfite reductase [NADPH] hemoprotein beta-component
- GenecysI
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids568 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
Catalytic activity
- hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 4 H+
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 siroheme per subunit.
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway
Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 425 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 431 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 470 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 474 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 474 | Fe (UniProtKB | ChEBI) of siroheme (UniProtKB | ChEBI); axial binding residue | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | sulfite reductase complex (NADPH) | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Molecular Function | sulfite reductase (ferredoxin) activity | |
Molecular Function | sulfite reductase (NADPH) activity | |
Biological Process | cysteine biosynthetic process | |
Biological Process | hydrogen sulfide biosynthetic process | |
Biological Process | sulfate assimilation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSulfite reductase [NADPH] hemoprotein beta-component
- EC number
- Short namesSiR-HP ; SiRHP
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Xanthomonas
Accessions
- Primary accessionQ8PHC8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000388527 | 1-568 | Sulfite reductase [NADPH] hemoprotein beta-component | ||
Interaction
Subunit
Alpha8-beta8. The alpha component is a flavoprotein, the beta component is a hemoprotein.
Structure
Sequence
- Sequence statusComplete
- Length568
- Mass (Da)62,418
- Last updated2002-10-01 v1
- Checksum4E86EDBFF11AE961
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE008923 EMBL· GenBank· DDBJ | AAM38174.1 EMBL· GenBank· DDBJ | Genomic DNA |