Q8P7H4 · RRAAH_XANCP
- ProteinPutative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids166 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).
Catalytic activity
- 4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate
Cofactor
Note: Divalent metal cation.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 74-77 | substrate | |||
Binding site | 96 | substrate | |||
Binding site | 97 | a divalent metal cation (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4-hydroxy-4-methyl-2-oxoglutarate aldolase activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxaloacetate decarboxylase activity | |
Molecular Function | ribonuclease inhibitor activity | |
Biological Process | regulation of RNA metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
- EC number
- Short namesHMG aldolase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Xanthomonas
Accessions
- Primary accessionQ8P7H4
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000209649 | 1-166 | Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length166
- Mass (Da)17,554
- Last updated2002-10-01 v1
- MD5 Checksum22BEB900EF2E7472749C8AB09088F1FE
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE008922 EMBL· GenBank· DDBJ | AAM41909.1 EMBL· GenBank· DDBJ | Genomic DNA |