Q8P6V8 · METXS_XANCP
- ProteinHomoserine O-succinyltransferase
- GenemetXS
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids369 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine.
Catalytic activity
- L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-succinyl-L-homoserine from L-homoserine: step 1/1.
Features
Showing features for active site, site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 172 | Nucleophile | ||||
Sequence: S | ||||||
Site | 173 | Important for substrate specificity | ||||
Sequence: Y | ||||||
Site | 209 | Important for acyl-CoA specificity | ||||
Sequence: R | ||||||
Binding site | 233 | substrate | ||||
Sequence: R | ||||||
Active site | 314 | |||||
Sequence: D | ||||||
Active site | 344 | |||||
Sequence: H | ||||||
Binding site | 345 | substrate | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | homoserine O-acetyltransferase activity | |
Molecular Function | homoserine O-succinyltransferase activity | |
Biological Process | homoserine metabolic process | |
Biological Process | methionine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameHomoserine O-succinyltransferase
- EC number
- Short namesHST
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Xanthomonas
Accessions
- Primary accessionQ8P6V8
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000440305 | 1-369 | Homoserine O-succinyltransferase | |||
Sequence: MVRIVPSARRTRAPAKLDGRSTPDIAMSLVTTASPLTTADTYTPAADSDAPPAVRGELVINLPMRHAGQRELRLRYELVGAEQAPVVFVAGGISAHRHLAASAVFPEKGWVEGLVGAGRALDPASRRLLAFDFLGADGSLDAPIDTADQADAIAALLDALGIARLHGFVGYSYGALVGLQFASRHAARLHTLVAVSGAHRAHPYAAAWRALQRRAVALGQLQCAEHHGLALARQFAMLSYRTPEEFSERFDAPPELINGRVRVAAEDYLDAAGAQYVARTPVNAYLRLSESIDLHRIDPAAVAVPTVVVAVEGDRLVPLADLVSLVEGLGPRGSLRVLRSPFGHDAFLKEIDRIDAILTTALRTTGETA |
Interaction
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-21 | Disordered | ||||
Sequence: MVRIVPSARRTRAPAKLDGRS | ||||||
Domain | 86-350 | AB hydrolase-1 | ||||
Sequence: VVFVAGGISAHRHLAASAVFPEKGWVEGLVGAGRALDPASRRLLAFDFLGADGSLDAPIDTADQADAIAALLDALGIARLHGFVGYSYGALVGLQFASRHAARLHTLVAVSGAHRAHPYAAAWRALQRRAVALGQLQCAEHHGLALARQFAMLSYRTPEEFSERFDAPPELINGRVRVAAEDYLDAAGAQYVARTPVNAYLRLSESIDLHRIDPAAVAVPTVVVAVEGDRLVPLADLVSLVEGLGPRGSLRVLRSPFGHDAFLKE | ||||||
Region | 92-95 | Important for substrate specificity | ||||
Sequence: GISA |
Sequence similarities
Belongs to the AB hydrolase superfamily. MetX family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length369
- Mass (Da)39,292
- Last updated2017-06-07 v2
- ChecksumC7893D2D991C2328
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LT613641 EMBL· GenBank· DDBJ | SCN13865.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE008922 EMBL· GenBank· DDBJ | AAM42129.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |