Q8P161 · MNME_STRP8

Function

function

Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm5s2U34.

Cofactor

K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.

Features

Showing features for binding site.

145850100150200250300350400450
TypeIDPosition(s)Description
Binding site26(6S)-5-formyl-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site88(6S)-5-formyl-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site127(6S)-5-formyl-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site234K+ (UniProtKB | ChEBI)
Binding site234-239GTP (UniProtKB | ChEBI)
Binding site238Mg2+ (UniProtKB | ChEBI)
Binding site253K+ (UniProtKB | ChEBI)
Binding site253-259GTP (UniProtKB | ChEBI)
Binding site255K+ (UniProtKB | ChEBI)
Binding site258K+ (UniProtKB | ChEBI)
Binding site259Mg2+ (UniProtKB | ChEBI)
Binding site278-281GTP (UniProtKB | ChEBI)
Binding site458(6S)-5-formyl-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functionmetal ion binding
Biological ProcesstRNA methylation
Biological ProcesstRNA wobble uridine modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA modification GTPase MnmE
  • EC number

Gene names

    • Name
      mnmE
    • Synonyms
      trmE
    • Ordered locus names
      spyM18_1045

Organism names

Accessions

  • Primary accession
    Q8P161

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001889341-458tRNA modification GTPase MnmE

Interaction

Subunit

Homodimer. Heterotetramer of two MnmE and two MnmG subunits.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain224-378TrmE-type G

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    458
  • Mass (Da)
    50,537
  • Last updated
    2002-10-01 v1
  • MD5 Checksum
    AAAAF59FDA7A5F6E9C668052D6AC4D81
MSITKEFDTITAISTPLGEGAIGIVRLSGTDALAIAQSVFKGKNLEQVASHTINYGHIIDPKTGTIIDEVMVSVMLAPKTFTRENVVEINTHGGIAVTNEILQLLIRQGARMAEPGEFTKRAFLNGRVDLTQAEAVMDIIRAKTDKAMTIAVKQLDGSLSQLINDTRQEILNTLAQVEVNIDYPEYDDVEEMTTALLREKTQEFQSLLENLLRTAKRGKILREGLSTAIIGRPNVGKSSLLNNLLREDKAIVTDIAGTTRDVIEEYVNIKGVPLKLVDTAGIRETDDLVEQIGVERSKKALQEADLVLLVLNASEKLTDQDRALLNLSQDSNRIILLNKTDLEQKIELEQLPDDYIPISVLTNQNINLIEDRINQLFFDNAGLVEQDATYLSNARHISLIEKAVQSLEAVNDGLALGMPVDLLQVDLTRTWEILGEITGDAAPDELITQLFSQFCLGK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE009949
EMBL· GenBank· DDBJ
AAL97675.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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