Q8NPZ2 · PIPS_CORGL

Function

function

Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Contains a di-nuclear catalytic Mg2+ center.

Pathway

Phospholipid metabolism; phosphatidylinositol phosphate biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site29-32a CDP-1,2-diacyl-sn-glycerol (UniProtKB | ChEBI)
Binding site66Mg2+ 1 (UniProtKB | ChEBI)
Binding site66Mg2+ 2 (UniProtKB | ChEBI)
Binding site69Mg2+ 1 (UniProtKB | ChEBI)
Binding site70a CDP-1,2-diacyl-sn-glycerol (UniProtKB | ChEBI)
Binding site74a CDP-1,2-diacyl-sn-glycerol (UniProtKB | ChEBI)
Binding site80a CDP-1,2-diacyl-sn-glycerol (UniProtKB | ChEBI)
Binding site87Mg2+ 1 (UniProtKB | ChEBI)
Binding site87Mg2+ 2 (UniProtKB | ChEBI)
Active site91Proton acceptor
Binding site91Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionmagnesium ion binding
Molecular Functionphosphotransferase activity, for other substituted phosphate groups
Biological Processphospholipid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylinositol phosphate synthase
  • EC number
  • Short names
    PIP synthase
  • Alternative names
    • CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase

Gene names

    • Ordered locus names
      Cgl1669

Organism names

Accessions

  • Primary accession
    Q8NPZ2
  • Secondary accessions
    • Q6M4V8

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane31-47Helical
Transmembrane53-72Helical
Transmembrane93-110Helical
Transmembrane116-133Helical
Transmembrane154-171Helical
Transmembrane177-194Helical

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004483641-219Phosphatidylinositol phosphate synthase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    219
  • Mass (Da)
    22,834
  • Last updated
    2002-10-01 v1
  • Checksum
    CFFB170796DF4DE5
MLGLHGRKPAQVIVEPVAKLMIKLKVTPNQLTLVSAGLTVGVALLLIPTGHLIWAAVLTGLFAAFDMIDGTVARMQGGGTKFGATLDATCDRITDGALFGAITWWLVYSYDAPQALVAASLVCLVASQVISYVKARGEASGFTMDGGLVERPERLIVSLVGLGLTGMGVPYAIDVALWALAAGSIYTVVQRLVMAGKSPLAKEFTKAPAGAKADYSNTK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000036
EMBL· GenBank· DDBJ
BAB99062.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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