Q8NPB7 · AFTC_CORGL

Function

function

Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the corynebacterial cell wall. Catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG.

Catalytic activity

  • Adds an alpha-D-arabinofuranosyl group from trans,octacis-decaprenylphospho-beta-D-arabinofuranose at the 3-O-position of an alpha-(1->5)-arabinofuranan chain attached to a beta-(1->5)-galactofuranan chain.
    EC:2.4.2.47 (UniProtKB | ENZYME | Rhea)

Pathway

Cell wall biogenesis; cell wall polysaccharide biosynthesis.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionhexosyltransferase activity
Biological Processcapsule polysaccharide biosynthetic process
Biological Processcell wall organization

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-(1->3)-arabinofuranosyltransferase
  • EC number
  • Alternative names
    • Arabinofuranan 3-O-arabinosyltransferase
    • Arabinofuranosyltransferase C

Gene names

    • Name
      aftC
    • Ordered locus names
      Cgl1897

Organism names

Accessions

  • Primary accession
    Q8NPB7
  • Secondary accessions
    • Q6M4C2

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane25-45Helical
Transmembrane81-101Helical
Transmembrane102-122Helical
Transmembrane125-145Helical
Transmembrane153-173Helical
Transmembrane183-203Helical
Transmembrane210-230Helical
Transmembrane266-286Helical
Transmembrane293-312Helical
Transmembrane327-349Helical
Transmembrane372-392Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Cells lacking this gene show reduced levels of cell wall-bound corynomycolic acid methyl esters (CMAMEs).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004517511-418Alpha-(1->3)-arabinofuranosyltransferase

Interaction

Protein-protein interaction databases

Family & Domains

Sequence

  • Sequence status
    Complete
  • Length
    418
  • Mass (Da)
    46,837
  • Last updated
    2002-10-01 v1
  • Checksum
    DA1F4DC16E60A490
MSFSPVAPSISAPTPRRSRWDSIGNAVAWPLAMLLMAHRFFVLAINGAVTDDFTTVYSALRRFVEGIPVYNEVYHFVDPHYLYNPGATLLLAPLGYITHFTLARWMFIAVNLLAIVLAFGLLTRLSGWALRSMVWPIAIALAMLTETVQNTLIFSNINGILLLMLAIFLWCVVHKKSWLGGLVIGLAILIKPMFLPLLFLPLVKKQWGSLILGILTPVIFNAVAWFLVPGASEYVTRTMPYLGETRDFANSSLPGLAIYFGMPTWMEITWFLIFGAMVGLAVLALLRFRNTEPYFWAATTTGVLLTGVFFLSSLGQMYYSMMIFPMIFTLLGSRSVFHNWVAWVAAYFFLSPDTFTSQRLPDVARWMEFFSATVGWGLLIVVTFVSALIWFIGDIRAKGTPSSPITTDPTHDHLERTA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000036
EMBL· GenBank· DDBJ
BAB99290.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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