Q8NP40 · IF2_CORGL

Function

function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.

Features

Showing features for binding site.

110041002003004005006007008009001,000
TypeIDPosition(s)Description
Binding site508-515GTP (UniProtKB | ChEBI)
Binding site558-562GTP (UniProtKB | ChEBI)
Binding site612-615GTP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Molecular Functiontranslation initiation factor activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Translation initiation factor IF-2

Gene names

    • Name
      infB
    • Ordered locus names
      Cgl1985, cg2176

Organism names

Accessions

  • Primary accession
    Q8NP40

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001371971-1004Translation initiation factor IF-2

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region36-393Disordered
Compositional bias76-96Pro residues
Compositional bias182-196Pro residues
Compositional bias220-234Pro residues
Compositional bias288-302Polar residues
Domain499-671tr-type G
Region508-515G1
Region533-537G2
Region558-561G3
Region612-615G4
Region648-650G5

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,004
  • Mass (Da)
    103,413
  • Last updated
    2002-10-01 v1
  • Checksum
    FC159DE2AE29283F
MPGKLRVHELAKQLGITSKELLATLKDKGEFVKTASSTIEPPVVKRMQEHYGSSGSDKSDTAAKPAAAKPAAPKPAASAAPKPGAPAKPAAPAAKPAPAAPSAASAAKPGAAPKPGVQAKPAAAAKPGAPAKPAAPAAPSAAKSGSAPKPAAAAKPAFSGPTPGDAAKKAEPAAKPGAEAPRPGGMPRPMGKPAPKPGARAPRVANNPFSTGGGERPAPRPGGGPRPGGGPRPGGGPRPQGQGRPGGQRDGQRDGQRDGQGNRGGQRQGAGAGGPRPQGGPRPQGGSRPQGGSAQGAQGAPSQERQGGGRRPSPAMMPPTPGQMPAKAPGKGGRGGQAGGGAGGGFNRGGGTGGGAGRGGRRGGTAGAFGRPGGAPRRGRKSKRQKRNEYESMQAPNVIGGVRLPDGKGATIRLARGASLADFADKIGADAAALVQALFNLGEMVTATASVSDETLQLLGEEMNYKVQVVSPEDEDRELLESFDLQFGEDEGGEADLAKRPPVVTVMGHVDHGKTRLLDTIRKANVGSDEAGGITQGIGAYQVKVNVEDTERTITFLDTPGHEAFTAMRARGAKSTDIAVLVVAADDGVMPQTVEAINHAKAADVPIVVAVNKIDKPEASPEKIRGQLTEYGLIPEEYGGDTIFVDISAKQGLNIDELLASVCLTADAELDLVANPEMDAQGVAIEAHLDRGRGPVATVIVQRGTLRVGDSIVAGDTYGRVRRMVDEYGRDVEEAGPSRPVQVQGLNGVPGAGDNLLVVEDDRIARQIANQRNARKRNALAARSRKRVSLEDLDSVLKEHSTLNLILKGDNAGSVEALEEALLKIEMDDEVQLNIIDRGVGAVTQTNVTLAAASDAVIIAFNVRAEGKATEEANAEGVDVRYYTIIYRAIEEVEAALKGMLKPIYEERVIGHAEIRAIFKASSVGLIAGCMVEDGKVRRNATVRIIRDGNVIAENAKIVSLRREKDDATEVSAGYECGMVLSYPDISVDDKIEVYEMVEVPREA

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias76-96Pro residues
Sequence conflict81in Ref. 2; CAF20326
Compositional bias182-196Pro residues
Compositional bias220-234Pro residues
Compositional bias288-302Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000036
EMBL· GenBank· DDBJ
BAB99378.1
EMBL· GenBank· DDBJ
Genomic DNA
BX927153
EMBL· GenBank· DDBJ
CAF20326.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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