Q8NKN9 · TPIS_THETK
- ProteinTriosephosphate isomerase
- GenetpiA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids226 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Catalytic activity
- D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate
Pathway
Carbohydrate biosynthesis; gluconeogenesis.
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9-11 | substrate | ||||
Sequence: NFK | ||||||
Active site | 93 | Electrophile | ||||
Sequence: H | ||||||
Active site | 141 | Proton acceptor | ||||
Sequence: E | ||||||
Binding site | 146 | substrate | ||||
Sequence: I | ||||||
Binding site | 181 | substrate | ||||
Sequence: G | ||||||
Binding site | 202-203 | substrate | ||||
Sequence: AS |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | triose-phosphate isomerase activity | |
Biological Process | gluconeogenesis | |
Biological Process | glycolytic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTriosephosphate isomerase
- EC number
- Short namesTIM ; TPI
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Thermoproteales > Thermoproteaceae > Thermoproteus
Accessions
- Primary accessionQ8NKN9
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000090349 | 1-226 | Triosephosphate isomerase | |||
Sequence: MRLPILIINFKAYGEAAGKRAVELAKAAERAARELGVNIVVAPNHLELGLVSQSVDIPVYAQGADVEAGGAHTAHVSLENIKEAGGSGVILNHSEAPLKLNDLARLVAKAKSLGLDVVVCAPDPRTSLAAAALGPHAVAVEPPELIGTGRAVSRYKPEAIVETVGLVSRHFPEVSVITGAGIESGDDVAAALRLGTRGVLLASAAVKAKDPYAKIVELAKPLSELR |
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length226
- Mass (Da)23,283
- Last updated2002-10-01 v1
- Checksum53BE6A0A5F492857
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ012066 EMBL· GenBank· DDBJ | CAB66162.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AJ515539 EMBL· GenBank· DDBJ | CAD56500.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FN869859 EMBL· GenBank· DDBJ | CCC81161.1 EMBL· GenBank· DDBJ | Genomic DNA |