Q8NKN9 · TPIS_THETK

Function

function

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).

Catalytic activity

Pathway

Carbohydrate biosynthesis; gluconeogenesis.
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.

Features

Showing features for binding site, active site.

122620406080100120140160180200220
TypeIDPosition(s)Description
Binding site9-11substrate
Active site93Electrophile
Active site141Proton acceptor
Binding site146substrate
Binding site181substrate
Binding site202-203substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functiontriose-phosphate isomerase activity
Biological Processgluconeogenesis
Biological Processglycolytic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Triosephosphate isomerase
  • EC number
  • Short names
    TIM
    ; TPI
  • Alternative names
    • Triose-phosphate isomerase

Gene names

    • Name
      tpiA
    • Synonyms
      tpi
    • Ordered locus names
      TTX_0494

Organism names

Accessions

  • Primary accession
    Q8NKN9
  • Secondary accessions
    • G4RNL7

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000903491-226Triosephosphate isomerase

Proteomic databases

Interaction

Subunit

Homotetramer; dimer of dimers.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the triosephosphate isomerase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    226
  • Mass (Da)
    23,283
  • Last updated
    2002-10-01 v1
  • Checksum
    53BE6A0A5F492857
MRLPILIINFKAYGEAAGKRAVELAKAAERAARELGVNIVVAPNHLELGLVSQSVDIPVYAQGADVEAGGAHTAHVSLENIKEAGGSGVILNHSEAPLKLNDLARLVAKAKSLGLDVVVCAPDPRTSLAAAALGPHAVAVEPPELIGTGRAVSRYKPEAIVETVGLVSRHFPEVSVITGAGIESGDDVAAALRLGTRGVLLASAAVKAKDPYAKIVELAKPLSELR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ012066
EMBL· GenBank· DDBJ
CAB66162.1
EMBL· GenBank· DDBJ
Genomic DNA
AJ515539
EMBL· GenBank· DDBJ
CAD56500.1
EMBL· GenBank· DDBJ
Genomic DNA
FN869859
EMBL· GenBank· DDBJ
CCC81161.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp