Q8NJN2 · KATG_TALMA
- ProteinCatalase-peroxidase
- GenekatG
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids748 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity (By similarity).
Plays a crucial role in oxidative stress response during infection (PubMed:23859079).
Acts as an antigen and elicits antibody response in P.marneffei-infected AIDS patients, healthy people working in mycological laboratory, and healthy people in an endemic area (PubMed:23859079).
Plays a crucial role in oxidative stress response during infection (PubMed:23859079).
Acts as an antigen and elicits antibody response in P.marneffei-infected AIDS patients, healthy people working in mycological laboratory, and healthy people in an endemic area (PubMed:23859079).
Catalytic activity
- AH2 + H2O2 = A + 2 H2O
Cofactor
Note: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.
Features
Showing features for site, active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | catalase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | cellular response to hydrogen peroxide | |
Biological Process | hydrogen peroxide catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCatalase-peroxidase
- EC number
- Short namesCP
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Trichocomaceae > Talaromyces > Talaromyces sect. Talaromyces
Accessions
- Primary accessionQ8NJN2
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Reduces the fungal tolerance to hydrogen peroxide but not to heat stress.
PTM/Processing
Features
Showing features for chain, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000354108 | 1-748 | Catalase-peroxidase | |||
Sequence: MAESKCPAHQHVLKANVGGAGTSNQDWWPDRLKLNILRQNNPVSNPLGEEFDYAAAFNSLDYFALKKDIQDLMTDSQDWWPADFGHYGGLFIRMAWHSAGTYRVADGRGGGGGGQQRFAPLNSWPDNVGLDKARRLLWPIKQKYGNKISWADLLLLTGNVALESMGFKTFGFSGGRADTWEVDESANWGGETTWLGNDVRYSGGKADHKDIHNRDLDKPLAAAHMGLIYVNPEGPDGNPDPIAAAKDIRTTFGRMAMNDEETVALIAGGHTFGKTHGAGPADKLGPEPEAADMAQQGLGWTNSFKSGKGPDTTTSGLEVTWTKTPTKWSNQFLEYLFRYDWELTKSPAGAHQWVAKNAEAFIPDAFDPSKKRKPMMLTTDLSLRYDPIYEKISRRFLEHPDQFADAFARAWFKLLHRDLGPRALYIGPEVPAEVLPWQDPVPAVDHPLISNEDASALKQRILASGVKPSSLISTAWASASTFRGSDKRGGANGARIRLSPQREWAVNNQPWLRETLSVLEAIQKQFNTSQSGGKKVSIADLIVLAGVAAVEKAARDAGYAVTVPFTPGRTDASQEQTDVQSFSDMEPIADGFRNYGSSTSRVRAEEWLIDKAQLLTLSAPELAVLIGGLRVLNTNYDGSAHGVFTQRPGKLTNDFFVNLLDMNTAWKSIGGVDLYEGTDRKTGAKKWTATRNDLVFGSNAELRAIAEVYGSSDGQEKFVKDFVAAWDKVMNLDRFDLKKKQSTSSHRL | ||||||
Cross-link | 96↔229 | Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-255) | ||||
Sequence: WHSAGTYRVADGRGGGGGGQQRFAPLNSWPDNVGLDKARRLLWPIKQKYGNKISWADLLLLTGNVALESMGFKTFGFSGGRADTWEVDESANWGGETTWLGNDVRYSGGKADHKDIHNRDLDKPLAAAHMGLIY | ||||||
Cross-link | 229↔255 | Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96) | ||||
Sequence: YVNPEGPDGNPDPIAAAKDIRTTFGRM |
Post-translational modification
Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.
Interaction
Subunit
Homodimer or homotetramer.
Structure
Sequence
- Sequence statusComplete
- Length748
- Mass (Da)82,374
- Last updated2002-10-01 v1
- Checksum81E0D77ECBC676E0