Q8NI47 · Q8NI47_HUMAN

  • Protein
    Phospholipase A2, membrane associated
  • Gene
    PLA2G2A
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

Catalytic activity

  • 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + H2O = (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoglycerol + H2O = 1-hexadecanoyl-sn-glycero-3-phosphoglycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H+
    This reaction proceeds in the forward direction.

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site35Ca2+ (UniProtKB | ChEBI)
Binding site37Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular region
Cellular Componentmitochondrial outer membrane
Molecular Functioncalcium ion binding
Molecular Functionphospholipase A2 activity
Biological Processarachidonic acid secretion
Biological Processdefense response to bacterium
Biological Processkilling of cells of another organism
Biological Processlipid catabolic process
Biological Processphospholipid metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipase A2, membrane associated
  • Alternative names
    • GIIC sPLA2
    • Group IIA phospholipase A2
    • Phosphatidylcholine 2-acylhydrolase 2A

Gene names

    • Name
      PLA2G2A

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8NI47

Subcellular Location

Mitochondrion outer membrane
; Peripheral membrane protein
Secreted

Keywords

  • Cellular component

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-48Phospholipase A2

Sequence similarities

Belongs to the phospholipase A2 family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    48
  • Mass (Da)
    5,168
  • Last updated
    2002-10-01 v1
  • Checksum
    6297E410A0FAAD92
LLQARGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDR

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue48

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF368841
EMBL· GenBank· DDBJ
AAM21271.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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