Q8NGN3 · O10G4_HUMAN
- ProteinOlfactory receptor 10G4
- GeneOR10G4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids311 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Odorant receptor.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | olfactory receptor activity | |
Biological Process | detection of chemical stimulus involved in sensory perception of smell |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOlfactory receptor 10G4
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8NGN3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-23 | Extracellular | ||||
Sequence: MSNASLVTAFILTGLPHAPGLDA | ||||||
Transmembrane | 24-44 | Helical; Name=1 | ||||
Sequence: LLFGIFLVVYVLTVLGNLLIL | ||||||
Topological domain | 45-52 | Cytoplasmic | ||||
Sequence: LVIRVDSH | ||||||
Transmembrane | 53-73 | Helical; Name=2 | ||||
Sequence: LHTPMYYFLTNLSFIDMWFST | ||||||
Topological domain | 74-98 | Extracellular | ||||
Sequence: VTVPKMLMTLVSPSGRAISFHSCVA | ||||||
Transmembrane | 99-119 | Helical; Name=3 | ||||
Sequence: QLYFFHFLGSTECFLYTVMSY | ||||||
Topological domain | 120-138 | Cytoplasmic | ||||
Sequence: DRYLAISYPLRYTSMMSGS | ||||||
Transmembrane | 139-159 | Helical; Name=4 | ||||
Sequence: RCALLATGTWLSGSLHSAVQT | ||||||
Topological domain | 160-196 | Extracellular | ||||
Sequence: ILTFHLPYCGPNQIQHYFCDAPPILKLACADTSANVM | ||||||
Transmembrane | 197-216 | Helical; Name=5 | ||||
Sequence: VIFVDIGIVASGCFVLIVLS | ||||||
Topological domain | 217-236 | Cytoplasmic | ||||
Sequence: YVSIVCSILRIRTSDGRRRA | ||||||
Transmembrane | 237-257 | Helical; Name=6 | ||||
Sequence: FQTCASHCIVVLCFFVPCVVI | ||||||
Topological domain | 258-268 | Extracellular | ||||
Sequence: YLRPGSMDAMD | ||||||
Transmembrane | 269-289 | Helical; Name=7 | ||||
Sequence: GVVAIFYTVLTPLLNPVVYTL | ||||||
Topological domain | 290-311 | Cytoplasmic | ||||
Sequence: RNKEVKKAVLKLRDKVAHPQRK |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_053275 | 24 | in dbSNP:rs547068 | |||
Sequence: L → P | ||||||
Natural variant | VAR_060025 | 101 | in dbSNP:rs4474449 | |||
Sequence: Y → C | ||||||
Natural variant | VAR_053276 | 134 | in dbSNP:rs1893766 | |||
Sequence: M → V | ||||||
Natural variant | VAR_060026 | 146 | in dbSNP:rs503223 | |||
Sequence: G → C | ||||||
Natural variant | VAR_060027 | 146 | in dbSNP:rs503223 | |||
Sequence: G → R | ||||||
Natural variant | VAR_060028 | 146 | in dbSNP:rs503223 | |||
Sequence: G → S | ||||||
Natural variant | VAR_053277 | 181 | in dbSNP:rs1893764 | |||
Sequence: P → S | ||||||
Natural variant | VAR_034283 | 195 | in dbSNP:rs4084209 | |||
Sequence: V → E | ||||||
Natural variant | VAR_053278 | 226 | in dbSNP:rs11219408 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_034284 | 235 | in dbSNP:rs4936880 | |||
Sequence: R → G | ||||||
Natural variant | VAR_053279 | 295 | in dbSNP:rs4936881 | |||
Sequence: K → Q |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 514 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000150697 | 1-311 | Olfactory receptor 10G4 | |||
Sequence: MSNASLVTAFILTGLPHAPGLDALLFGIFLVVYVLTVLGNLLILLVIRVDSHLHTPMYYFLTNLSFIDMWFSTVTVPKMLMTLVSPSGRAISFHSCVAQLYFFHFLGSTECFLYTVMSYDRYLAISYPLRYTSMMSGSRCALLATGTWLSGSLHSAVQTILTFHLPYCGPNQIQHYFCDAPPILKLACADTSANVMVIFVDIGIVASGCFVLIVLSYVSIVCSILRIRTSDGRRRAFQTCASHCIVVLCFFVPCVVIYLRPGSMDAMDGVVAIFYTVLTPLLNPVVYTLRNKEVKKAVLKLRDKVAHPQRK | ||||||
Glycosylation | 3 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 96↔188 | |||||
Sequence: CVAQLYFFHFLGSTECFLYTVMSYDRYLAISYPLRYTSMMSGSRCALLATGTWLSGSLHSAVQTILTFHLPYCGPNQIQHYFCDAPPILKLAC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8NGN3 | B4GALT1 Q86XA6 | 3 | EBI-17208485, EBI-18325557 | |
BINARY | Q8NGN3 | RPL12 P30050-2 | 3 | EBI-17208485, EBI-17208508 |
Protein-protein interaction databases
Miscellaneous
Structure
Sequence
- Sequence statusComplete
- Length311
- Mass (Da)34,569
- Last updated2002-10-01 v1
- ChecksumA46CBCE6EF461752
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB065757 EMBL· GenBank· DDBJ | BAC05977.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK004502 EMBL· GenBank· DDBJ | DAA04900.1 EMBL· GenBank· DDBJ | Genomic DNA |