Q8NGK4 · O52K1_HUMAN
- ProteinOlfactory receptor 52K1
- GeneOR52K1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids314 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Odorant receptor.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | G protein-coupled receptor activity | |
Molecular Function | olfactory receptor activity |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOlfactory receptor 52K1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8NGK4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-27 | Extracellular | ||||
Sequence: MLPSNITSTHPAVFLLVGIPGLEHLHA | ||||||
Transmembrane | 28-48 | Helical; Name=1 | ||||
Sequence: WISIPFCFAYTLALLGNCTLL | ||||||
Topological domain | 49-56 | Cytoplasmic | ||||
Sequence: FIIQADAA | ||||||
Transmembrane | 57-77 | Helical; Name=2 | ||||
Sequence: LHEPMYLFLAMLATIDLVLSS | ||||||
Topological domain | 78-101 | Extracellular | ||||
Sequence: TTLPKMLAIFWFRDQEINFFACLV | ||||||
Transmembrane | 102-122 | Helical; Name=3 | ||||
Sequence: QMFFLHSFSIMESAVLLAMAF | ||||||
Topological domain | 123-141 | Cytoplasmic | ||||
Sequence: DRYVAICKPLHYTTVLTGS | ||||||
Transmembrane | 142-162 | Helical; Name=4 | ||||
Sequence: LITKIGMAAVARAVTLMTPLP | ||||||
Topological domain | 163-198 | Extracellular | ||||
Sequence: FLLRRFHYCRGPVIAHCYCEHMAVVRLACGDTSFNN | ||||||
Transmembrane | 199-219 | Helical; Name=5 | ||||
Sequence: IYGIAVAMFIVVLDLLFVILS | ||||||
Topological domain | 220-239 | Cytoplasmic | ||||
Sequence: YVFILQAVLQLASQEARYKA | ||||||
Transmembrane | 240-260 | Helical; Name=6 | ||||
Sequence: FGTCVSHIGAILSTYTPVVIS | ||||||
Topological domain | 261-275 | Extracellular | ||||
Sequence: SVMHRVARHAAPRVH | ||||||
Transmembrane | 276-296 | Helical; Name=7 | ||||
Sequence: ILLAIFYLLFPPMVNPIIYGV | ||||||
Topological domain | 297-314 | Cytoplasmic | ||||
Sequence: KTKQIREYVLSLFQRKNM |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_060038 | 52 | in dbSNP:rs96489 | |||
Sequence: Q → R | ||||||
Natural variant | VAR_060039 | 153 | in dbSNP:rs331510 | |||
Sequence: R → W |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 419 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000150781 | 1-314 | Olfactory receptor 52K1 | |||
Sequence: MLPSNITSTHPAVFLLVGIPGLEHLHAWISIPFCFAYTLALLGNCTLLFIIQADAALHEPMYLFLAMLATIDLVLSSTTLPKMLAIFWFRDQEINFFACLVQMFFLHSFSIMESAVLLAMAFDRYVAICKPLHYTTVLTGSLITKIGMAAVARAVTLMTPLPFLLRRFHYCRGPVIAHCYCEHMAVVRLACGDTSFNNIYGIAVAMFIVVLDLLFVILSYVFILQAVLQLASQEARYKAFGTCVSHIGAILSTYTPVVISSVMHRVARHAAPRVHILLAIFYLLFPPMVNPIIYGVKTKQIREYVLSLFQRKNM | ||||||
Glycosylation | 5 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 99↔191 | |||||
Sequence: CLVQMFFLHSFSIMESAVLLAMAFDRYVAICKPLHYTTVLTGSLITKIGMAAVARAVTLMTPLPFLLRRFHYCRGPVIAHCYCEHMAVVRLAC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Sequence
- Sequence statusComplete
- Length314
- Mass (Da)35,231
- Last updated2010-05-18 v2
- Checksum4717C5B7F18AC68E
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8Y546 | A0A2R8Y546_HUMAN | OR52K1 | 301 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB065790 EMBL· GenBank· DDBJ | BAC06009.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC010930 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC137056 EMBL· GenBank· DDBJ | AAI37057.1 EMBL· GenBank· DDBJ | mRNA | ||
BC137059 EMBL· GenBank· DDBJ | AAI37060.1 EMBL· GenBank· DDBJ | mRNA | ||
BK004257 EMBL· GenBank· DDBJ | DAA04655.1 EMBL· GenBank· DDBJ | Genomic DNA |