Q8NG41 · NPB_HUMAN

  • Protein
    Neuropeptide B
  • Gene
    NPB
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

May be involved in the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular FunctionG protein-coupled receptor binding
Biological Processfeeding behavior
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processneuropeptide signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      NPB
    • Synonyms
      PPL7, PPNPB

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8NG41
  • Secondary accessions
    • A0AUX9
    • A6NJD6
    • B9EJC3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 192 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, peptide, propeptide.

TypeIDPosition(s)Description
Signal1-24
PeptidePRO_000001983725-48Neuropeptide B-23
PeptidePRO_000001983625-53Neuropeptide B-29
PropeptidePRO_000001983856-125

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Widely expressed in the central nervous system. High levels are found in substantia nigra, hypothalamus, hippocampus, spinal cord, placenta and fetal brain; lower levels are found in testis, uterus and ovary. Also detected at high levels in colorectal adenocarcinoma.

Gene expression databases

Organism-specific databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region54-73Disordered

Sequence similarities

Belongs to the neuropeptide B/W family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    125
  • Mass (Da)
    13,097
  • Last updated
    2002-10-01 v1
  • Checksum
    98CBFAB33B42AC90
MARSATLAAAALALCLLLAPPGLAWYKPAAGHSSYSVGRAAGLLSGLRRSPYARRSQPYRGAEPPGGAGASPELQLHPRLRSLAVCVQDVAPNLQRCERLPDGRGTYQCKANVFLSLRAADCLAA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
I3NI19I3NI19_HUMANNPB156

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB085942
EMBL· GenBank· DDBJ
BAC07175.1
EMBL· GenBank· DDBJ
mRNA
AF525737
EMBL· GenBank· DDBJ
AAP80794.1
EMBL· GenBank· DDBJ
mRNA
AF525738
EMBL· GenBank· DDBJ
AAP80795.1
EMBL· GenBank· DDBJ
Transcribed RNA
AL360181
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC126128
EMBL· GenBank· DDBJ
AAI26129.1
EMBL· GenBank· DDBJ
mRNA
BC126485
EMBL· GenBank· DDBJ
AAI26486.1
EMBL· GenBank· DDBJ
mRNA
BC146875
EMBL· GenBank· DDBJ
AAI46876.1
EMBL· GenBank· DDBJ
mRNA
BC146890
EMBL· GenBank· DDBJ
AAI46891.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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