TANK Binding Kinase 1 Promotes BACH1 Degradation through Both Phosphorylation-Dependent and -Independent Mechanisms without Relying on Heme and FBXO22.
FBXO22 plays a tumor-promoting role by ubiquitylating and degrading nuclear PTEN. In accordance FBXO22 is overexpressed in various cancer types and contributes to nuclear PTEN downregulation in colorectal cancer tissues.
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