Q8NE63 · HIPK4_HUMAN

  • Protein
    Homeodomain-interacting protein kinase 4
  • Gene
    HIPK4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity).
May act as a corepressor of transcription factors (Potential)

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site17-25ATP (UniProtKB | ChEBI)
Binding site40ATP (UniProtKB | ChEBI)
Active site136Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionhistone kinase activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Molecular Functionprotein tyrosine kinase activity
Biological Processregulation of signal transduction by p53 class mediator

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homeodomain-interacting protein kinase 4
  • EC number

Gene names

    • Name
      HIPK4

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8NE63
  • Secondary accessions
    • A8K863
    • Q96M54

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_040554106in dbSNP:rs34434715
Natural variantVAR_040555171in dbSNP:rs55964225
Natural variantVAR_030578302in dbSNP:rs11670988
Natural variantVAR_040556381in dbSNP:rs55760165
Natural variantVAR_040557386in dbSNP:rs56365273
Natural variantVAR_040558406in dbSNP:rs56094851
Natural variantVAR_040559421in dbSNP:rs56117722
Natural variantVAR_040560481in dbSNP:rs55801979

Variants

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The viewer provides 706 variants from UniProt as well as other sources including ClinVar and dbSNP.

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Organism-specific databases

Miscellaneous

Chemistry

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002324011-616Homeodomain-interacting protein kinase 4
Modified residue511Phosphoserine

Post-translational modification

Autophosphorylated.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8NE63APPBP2 Q926243EBI-6381114, EBI-743771
BINARY Q8NE63HSP90AB1 P082382EBI-6381114, EBI-352572
BINARY Q8NE63YWHAE P622582EBI-6381114, EBI-356498

Protein-protein interaction databases

Chemistry

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain11-347Protein kinase
Region486-616Disordered
Compositional bias495-509Polar residues
Compositional bias547-561Basic and acidic residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    616
  • Mass (Da)
    69,425
  • Last updated
    2002-10-01 v1
  • Checksum
    02429E8F2070C6C0
MSTIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTHYYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYCLAEEKEAAGMGSVAGSSPFFREEKAPGMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPLKAAITGHHVPDSGPEPILAFYSSRLAGRHKARKPPAGSKSDSNFSNLIRLSQVSPEDDRPCRGSSWEEGEHLGASAEPLAILQRDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHGPPRGATSFLQHVTGHH

Sequence caution

The sequence BAB71458.1 differs from that shown. Reason: Miscellaneous discrepancy Aberrant splicing.

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict374in Ref. 1; BAB71458
Sequence conflict445in Ref. 1; BAB71458
Compositional bias495-509Polar residues
Compositional bias547-561Basic and acidic residues
Sequence conflict581in Ref. 1; BAF84917

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK057380
EMBL· GenBank· DDBJ
BAB71458.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
AK292228
EMBL· GenBank· DDBJ
BAF84917.1
EMBL· GenBank· DDBJ
mRNA
BC034501
EMBL· GenBank· DDBJ
AAH34501.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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