Q8NE63 · HIPK4_HUMAN
- ProteinHomeodomain-interacting protein kinase 4
- GeneHIPK4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids616 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity).
May act as a corepressor of transcription factors (Potential)
May act as a corepressor of transcription factors (Potential)
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | histone kinase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | protein tyrosine kinase activity | |
Biological Process | regulation of signal transduction by p53 class mediator |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHomeodomain-interacting protein kinase 4
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8NE63
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_040554 | 106 | in dbSNP:rs34434715 | |||
Sequence: A → T | ||||||
Natural variant | VAR_040555 | 171 | in dbSNP:rs55964225 | |||
Sequence: V → M | ||||||
Natural variant | VAR_030578 | 302 | in dbSNP:rs11670988 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_040556 | 381 | in dbSNP:rs55760165 | |||
Sequence: T → M | ||||||
Natural variant | VAR_040557 | 386 | in dbSNP:rs56365273 | |||
Sequence: A → T | ||||||
Natural variant | VAR_040558 | 406 | in dbSNP:rs56094851 | |||
Sequence: S → R | ||||||
Natural variant | VAR_040559 | 421 | in dbSNP:rs56117722 | |||
Sequence: G → S | ||||||
Natural variant | VAR_040560 | 481 | in dbSNP:rs55801979 | |||
Sequence: R → C |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 706 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000232401 | 1-616 | Homeodomain-interacting protein kinase 4 | |||
Sequence: MSTIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTHYYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYCLAEEKEAAGMGSVAGSSPFFREEKAPGMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPLKAAITGHHVPDSGPEPILAFYSSRLAGRHKARKPPAGSKSDSNFSNLIRLSQVSPEDDRPCRGSSWEEGEHLGASAEPLAILQRDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHGPPRGATSFLQHVTGHH | ||||||
Modified residue | 511 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Autophosphorylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8NE63 | APPBP2 Q92624 | 3 | EBI-6381114, EBI-743771 | |
BINARY | Q8NE63 | HSP90AB1 P08238 | 2 | EBI-6381114, EBI-352572 | |
BINARY | Q8NE63 | YWHAE P62258 | 2 | EBI-6381114, EBI-356498 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 11-347 | Protein kinase | ||||
Sequence: YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFV | ||||||
Region | 486-616 | Disordered | ||||
Sequence: HKARKPPAGSKSDSNFSNLIRLSQVSPEDDRPCRGSSWEEGEHLGASAEPLAILQRDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHGPPRGATSFLQHVTGHH | ||||||
Compositional bias | 495-509 | Polar residues | ||||
Sequence: SKSDSNFSNLIRLSQ | ||||||
Compositional bias | 547-561 | Basic and acidic residues | ||||
Sequence: NIDNMTMEAERPDPE |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length616
- Mass (Da)69,425
- Last updated2002-10-01 v1
- Checksum02429E8F2070C6C0
Sequence caution
Features
Showing features for sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 374 | in Ref. 1; BAB71458 | ||||
Sequence: Q → R | ||||||
Sequence conflict | 445 | in Ref. 1; BAB71458 | ||||
Sequence: T → A | ||||||
Compositional bias | 495-509 | Polar residues | ||||
Sequence: SKSDSNFSNLIRLSQ | ||||||
Compositional bias | 547-561 | Basic and acidic residues | ||||
Sequence: NIDNMTMEAERPDPE | ||||||
Sequence conflict | 581 | in Ref. 1; BAF84917 | ||||
Sequence: E → G |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK057380 EMBL· GenBank· DDBJ | BAB71458.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AK292228 EMBL· GenBank· DDBJ | BAF84917.1 EMBL· GenBank· DDBJ | mRNA | ||
BC034501 EMBL· GenBank· DDBJ | AAH34501.1 EMBL· GenBank· DDBJ | mRNA |