PKA-binding domain of AKAP8 is essential for direct interaction with DPY30 protein.
- AnnotationThe PKA-binding domain of AKAP8 and the C-terminal domain of DPY30 also called Dpy-30 motif are crucial for the interaction between these proteins. AKAP8 interacts with DPY30 and the RII alpha regulatory subunit of PKA both in the interphase and in mitotic cells. A single amino acid substitution in DPY30 L69D affects its dimerization and completely abolishes its interaction with AKAP8.
- CategoriesInteraction
- SourceGeneRif: 10270