Q8NDW8 · TT21A_HUMAN
- ProteinTetratricopeptide repeat protein 21A
- GeneTTC21A
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1320 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Intraflagellar transport (IFT)-associated protein required for spermatogenesis (PubMed:30929735).
Required for sperm flagellar formation and intraflagellar transport (PubMed:30929735).
Required for sperm flagellar formation and intraflagellar transport (PubMed:30929735).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cilium | |
Cellular Component | intraciliary transport particle A | |
Biological Process | flagellated sperm motility | |
Biological Process | intraciliary retrograde transport | |
Biological Process | protein localization to cilium | |
Biological Process | spermatid development |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTetratricopeptide repeat protein 21A
- Short namesTPR repeat protein 21A
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8NDW8
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Disease & Variants
Involvement in disease
Spermatogenic failure 37 (SPGF37)
- Note
- DescriptionAn autosomal recessive infertility disorder characterized by asthenoteratozoospermia. Spermatozoa exhibit multiple morphologic abnormalities, primarily consisting of short or absent flagella, and neck defects at the head-tail junction.
- See alsoMIM:618429
Natural variants in SPGF37
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_082207 | 114 | Y>C | in SPGF37; dbSNP:rs750057655 | |
VAR_082208 | 777-1320 | missing | in SPGF37 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_032879 | 91 | in dbSNP:rs1112438 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_032880 | 108 | in dbSNP:rs17855763 | |||
Sequence: V → L | ||||||
Natural variant | VAR_082207 | 114 | in SPGF37; dbSNP:rs750057655 | |||
Sequence: Y → C | ||||||
Natural variant | VAR_032881 | 290 | in dbSNP:rs1274972 | |||
Sequence: R → K | ||||||
Natural variant | VAR_032882 | 293 | in dbSNP:rs1274971 | |||
Sequence: E → K | ||||||
Natural variant | VAR_032883 | 622 | in dbSNP:rs35581078 | |||
Sequence: R → W | ||||||
Natural variant | VAR_059861 | 719 | in dbSNP:rs9861353 | |||
Sequence: R → H | ||||||
Natural variant | VAR_032884 | 719 | in dbSNP:rs9861353 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_082208 | 777-1320 | in SPGF37 | |||
Sequence: Missing | ||||||
Natural variant | VAR_032885 | 1055 | in dbSNP:rs35934336 | |||
Sequence: R → L | ||||||
Natural variant | VAR_032886 | 1160 | in dbSNP:rs34201693 | |||
Sequence: S → R | ||||||
Natural variant | VAR_032887 | 1316 | in dbSNP:rs704959 | |||
Sequence: R → K |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,409 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000291915 | 1-1320 | Tetratricopeptide repeat protein 21A | |||
Sequence: MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATREKANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDYPKIREEILEKARRSLRP |
Proteomic databases
PTM databases
Expression
Tissue specificity
Strongly expressed in testis.
Developmental stage
Expressed in preleptotene spermatocytes, pachytene spermatocytes, round spermatids and elongated spermatids (at protein level).
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 4-38 | TPR 1 | ||||
Sequence: NDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSND | ||||||
Repeat | 110-143 | TPR 2 | ||||
Sequence: GTALYYAGLFLWLIGRHDKAKEYIDRMLKISRGF | ||||||
Repeat | 146-180 | TPR 3 | ||||
Sequence: AYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDV | ||||||
Repeat | 181-213 | TPR 4 | ||||
Sequence: LGLMGKAMYFMMQQNYSEALEVVNQITVTSGSF | ||||||
Repeat | 215-247 | TPR 5 | ||||
Sequence: PALVLKMQLFLARQDWEQTVEMGHRILEKDESN | ||||||
Repeat | 334-367 | TPR 6 | ||||
Sequence: VHVATELGYLFILKNQVKEALLWYSEAMKLDKDG | ||||||
Repeat | 502-534 | TPR 7 | ||||
Sequence: IDPLYLMAQVRYYSELENAQSILQRCLELDPAS | ||||||
Repeat | 572-605 | TPR 8 | ||||
Sequence: PLYHLIKARALNKAGDYPEAIKTLKMVIKLPALK | ||||||
Repeat | 728-761 | TPR 9 | ||||
Sequence: PHTSLLLGDALMSILEPEKALEVYDEAYRQNPHD | ||||||
Repeat | 762-795 | TPR 10 | ||||
Sequence: ASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQD | ||||||
Repeat | 797-828 | TPR 11 | ||||
Sequence: LCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQ | ||||||
Repeat | 837-869 | TPR 12 | ||||
Sequence: VKCLLLLAKVYKSHKKEAVIETLNKALDLQSRI | ||||||
Repeat | 889-922 | TPR 13 | ||||
Sequence: ASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTD | ||||||
Repeat | 924-956 | TPR 14 | ||||
Sequence: KVMLELAQLYLLQGHLDLCEQHCAILLQTEQNH | ||||||
Repeat | 957-990 | TPR 15 | ||||
Sequence: ETASVLMADLMFRKQKHEAAINLYHQVLEKAPDN | ||||||
Repeat | 1028-1061 | TPR 16 | ||||
Sequence: PGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWG | ||||||
Repeat | 1201-1234 | TPR 17 | ||||
Sequence: EKSWLLLADIYCQGSKFDLALELLRRCVQYNKSC | ||||||
Repeat | 1236-1268 | TPR 18 | ||||
Sequence: KAYEYMGFIMEKEQSYKDAVTNYKLAWKYSHHA | ||||||
Repeat | 1270-1303 | TPR 19 | ||||
Sequence: PAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDY |
Sequence similarities
Belongs to the TTC21 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
Q8NDW8-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,320
- Mass (Da)150,944
- Last updated2010-05-18 v3
- ChecksumCFB949A8E2B702DE
Q8NDW8-3
- Name3
- Differences from canonical
- 1-879: Missing
Q8NDW8-5
- Name5
Q8NDW8-6
- Name6
Q8NDW8-7
- Name7
- Differences from canonical
- 515-515: S → SG
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A804HK20 | A0A804HK20_HUMAN | TTC21A | 1313 | ||
A0A0B4J1Y2 | A0A0B4J1Y2_HUMAN | TTC21A | 1143 | ||
A0A0C4DH51 | A0A0C4DH51_HUMAN | TTC21A | 110 |
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_026297 | 1-879 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_038428 | 147-187 | in isoform 6 | |||
Sequence: Missing | ||||||
Sequence conflict | 153 | in Ref. 1; CAD31647 | ||||
Sequence: V → G | ||||||
Sequence conflict | 174 | in Ref. 2; BAG63718 | ||||
Sequence: I → T | ||||||
Alternative sequence | VSP_038429 | 268-275 | in isoform 5 and isoform 6 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_038430 | 386-396 | in isoform 5 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_038431 | 515 | in isoform 5, isoform 6 and isoform 7 | |||
Sequence: S → SG | ||||||
Sequence conflict | 802 | in Ref. 2; BAG63755 | ||||
Sequence: G → D | ||||||
Sequence conflict | 803 | in Ref. 1; CAD31647 | ||||
Sequence: K → E | ||||||
Sequence conflict | 838 | in Ref. 2; BAG63718 | ||||
Sequence: K → R | ||||||
Sequence conflict | 1095 | in Ref. 1; CAD31647 | ||||
Sequence: M → T | ||||||
Sequence conflict | 1165 | in Ref. 2; BAC04129 | ||||
Sequence: L → P | ||||||
Sequence conflict | 1291 | in Ref. 2; BAG63755 | ||||
Sequence: E → K |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ487015 EMBL· GenBank· DDBJ | CAD31647.1 EMBL· GenBank· DDBJ | mRNA | ||
AK093313 EMBL· GenBank· DDBJ | BAC04129.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK098528 EMBL· GenBank· DDBJ | BAC05323.1 EMBL· GenBank· DDBJ | mRNA | ||
AK302408 EMBL· GenBank· DDBJ | BAG63718.1 EMBL· GenBank· DDBJ | mRNA | ||
AK302465 EMBL· GenBank· DDBJ | BAG63755.1 EMBL· GenBank· DDBJ | mRNA | ||
AC092053 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC138124 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |