Q8NDW8 · TT21A_HUMAN

  • Protein
    Tetratricopeptide repeat protein 21A
  • Gene
    TTC21A
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Intraflagellar transport (IFT)-associated protein required for spermatogenesis (PubMed:30929735).
Required for sperm flagellar formation and intraflagellar transport (PubMed:30929735).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcilium
Cellular Componentintraciliary transport particle A
Biological Processflagellated sperm motility
Biological Processintraciliary retrograde transport
Biological Processprotein localization to cilium
Biological Processspermatid development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Tetratricopeptide repeat protein 21A
  • Short names
    TPR repeat protein 21A
  • Alternative names
    • Stress-inducible protein 2

Gene names

    • Name
      TTC21A
    • Synonyms
      STI2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8NDW8
  • Secondary accessions
    • A1L388
    • B4DYF6
    • B4DYJ3
    • D3YTE7
    • D4PHA5

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Involvement in disease

Spermatogenic failure 37 (SPGF37)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    An autosomal recessive infertility disorder characterized by asthenoteratozoospermia. Spermatozoa exhibit multiple morphologic abnormalities, primarily consisting of short or absent flagella, and neck defects at the head-tail junction.
  • See also
    MIM:618429
Natural variants in SPGF37
Variant IDPosition(s)ChangeDescription
VAR_082207114Y>Cin SPGF37; dbSNP:rs750057655
VAR_082208777-1320missingin SPGF37

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_03287991in dbSNP:rs1112438
Natural variantVAR_032880108in dbSNP:rs17855763
Natural variantVAR_082207114in SPGF37; dbSNP:rs750057655
Natural variantVAR_032881290in dbSNP:rs1274972
Natural variantVAR_032882293in dbSNP:rs1274971
Natural variantVAR_032883622in dbSNP:rs35581078
Natural variantVAR_059861719in dbSNP:rs9861353
Natural variantVAR_032884719in dbSNP:rs9861353
Natural variantVAR_082208777-1320in SPGF37
Natural variantVAR_0328851055in dbSNP:rs35934336
Natural variantVAR_0328861160in dbSNP:rs34201693
Natural variantVAR_0328871316in dbSNP:rs704959

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,409 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002919151-1320Tetratricopeptide repeat protein 21A

Proteomic databases

PTM databases

Expression

Tissue specificity

Strongly expressed in testis.

Developmental stage

Expressed in preleptotene spermatocytes, pachytene spermatocytes, round spermatids and elongated spermatids (at protein level).

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with IFT20 (PubMed:30929735).
Interacts with IFT52 (PubMed:30929735).
Interacts with IFT140 (PubMed:30929735).
Interacts with CEP78; regulating IFT20 stability and localization (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat4-38TPR 1
Repeat110-143TPR 2
Repeat146-180TPR 3
Repeat181-213TPR 4
Repeat215-247TPR 5
Repeat334-367TPR 6
Repeat502-534TPR 7
Repeat572-605TPR 8
Repeat728-761TPR 9
Repeat762-795TPR 10
Repeat797-828TPR 11
Repeat837-869TPR 12
Repeat889-922TPR 13
Repeat924-956TPR 14
Repeat957-990TPR 15
Repeat1028-1061TPR 16
Repeat1201-1234TPR 17
Repeat1236-1268TPR 18
Repeat1270-1303TPR 19

Sequence similarities

Belongs to the TTC21 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (5)
  • Sequence status
    Complete

This entry describes 5 isoforms produced by Alternative splicing.

Q8NDW8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,320
  • Mass (Da)
    150,944
  • Last updated
    2010-05-18 v3
  • Checksum
    CFB949A8E2B702DE
MSSNDSSLMAGIIYYSQEKYFHHVQQAAAVGLEKFSNDPVLKFFKAYGVLKEEHIQDAISDLESIRHHPDVSLCSTMALIYAHKRCEIIDREAIQELEYSLKEIRKTVSGTALYYAGLFLWLIGRHDKAKEYIDRMLKISRGFREAYVLRGWVDLTSDKPHTAKKAIEYLEQGIQDTKDVLGLMGKAMYFMMQQNYSEALEVVNQITVTSGSFLPALVLKMQLFLARQDWEQTVEMGHRILEKDESNIDACQILTVHELAREGNMTTVSSLKTQKATNHVRNLIKALETREPENPSLHLKKIIVVSRLCGSHQVILGLVCSFIERTFMATPSYVHVATELGYLFILKNQVKEALLWYSEAMKLDKDGMAGLTGIILCHILEGHLEEAEYRLEFLKEVQKSLGKSEVLIFLQALLMSRKHKGEEETTALLKEAVELHFSSMQGIPLGSEYFEKLDPYFLVCIAKEYLLFCPKQPRLPGQIVSPLLKQVAVILNPVVKAAPALIDPLYLMAQVRYYSELENAQSILQRCLELDPASVDAHLLMCQIYLAQGNFGMCFHCLELGVSHNFQVRDHPLYHLIKARALNKAGDYPEAIKTLKMVIKLPALKKEEGRKFLRPSVQPSQRASILLELVEALRLNGELHEATKVMQDTINEFGGTPEENRITIANVDLVLSKGNVDVALNMLRNILPKQSCYMEAREKMANIYLQTLRDRRLYIRCYRELCEHLPGPHTSLLLGDALMSILEPEKALEVYDEAYRQNPHDASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDLGKLLLKLKKVNKAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLNKALDLQSRILKRVPLEQPEMIPSQKQLAASICIQFAEHYLAEKEYDKAVQSYKDVFSYLPTDNKVMLELAQLYLLQGHLDLCEQHCAILLQTEQNHETASVLMADLMFRKQKHEAAINLYHQVLEKAPDNFLVLHKLIDLLRRSGKLEDIPAFFELAKKVSSRVPLEPGFNYCRGIYCWHIGQPNEALKFLNKARKDSTWGQSAIYHMVQICLNPDNEVVGGEAFENQGAESNYMEKKELEQQGVSTAEKLLREFYPHSDSSQTQLRLLQGLCRLATREKANMEAALGSFIQIAQAEKDSVPALLALAQAYVFLKQIPKARMQLKRLAKTPWVLSEAEDLEKSWLLLADIYCQGSKFDLALELLRRCVQYNKSCYKAYEYMGFIMEKEQSYKDAVTNYKLAWKYSHHANPAIGFKLAFNYLKDKKFVEAIEICNDVLREHPDYPKIREEILEKARRSLRP

Q8NDW8-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8NDW8-5

Q8NDW8-6

Q8NDW8-7

  • Name
    7
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A804HK20A0A804HK20_HUMANTTC21A1313
A0A0B4J1Y2A0A0B4J1Y2_HUMANTTC21A1143
A0A0C4DH51A0A0C4DH51_HUMANTTC21A110

Sequence caution

The sequence BAC04129.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0262971-879in isoform 3
Alternative sequenceVSP_038428147-187in isoform 6
Sequence conflict153in Ref. 1; CAD31647
Sequence conflict174in Ref. 2; BAG63718
Alternative sequenceVSP_038429268-275in isoform 5 and isoform 6
Alternative sequenceVSP_038430386-396in isoform 5
Alternative sequenceVSP_038431515in isoform 5, isoform 6 and isoform 7
Sequence conflict802in Ref. 2; BAG63755
Sequence conflict803in Ref. 1; CAD31647
Sequence conflict838in Ref. 2; BAG63718
Sequence conflict1095in Ref. 1; CAD31647
Sequence conflict1165in Ref. 2; BAC04129
Sequence conflict1291in Ref. 2; BAG63755

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ487015
EMBL· GenBank· DDBJ
CAD31647.1
EMBL· GenBank· DDBJ
mRNA
AK093313
EMBL· GenBank· DDBJ
BAC04129.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK098528
EMBL· GenBank· DDBJ
BAC05323.1
EMBL· GenBank· DDBJ
mRNA
AK302408
EMBL· GenBank· DDBJ
BAG63718.1
EMBL· GenBank· DDBJ
mRNA
AK302465
EMBL· GenBank· DDBJ
BAG63755.1
EMBL· GenBank· DDBJ
mRNA
AC092053
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC138124
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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