Q8NDV7 · TNR6A_HUMAN
- ProteinTrinucleotide repeat-containing gene 6A protein
- GeneTNRC6A
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1962 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Miscellaneous
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | Golgi apparatus | |
Cellular Component | intracellular membrane-bounded organelle | |
Cellular Component | nucleoplasm | |
Cellular Component | P-body | |
Cellular Component | RISC complex | |
Molecular Function | protein-macromolecule adaptor activity | |
Molecular Function | RNA binding | |
Biological Process | cellular response to starvation | |
Biological Process | endoderm development | |
Biological Process | miRNA-mediated gene silencing by inhibition of translation | |
Biological Process | miRNA-mediated post-transcriptional gene silencing | |
Biological Process | P-body assembly | |
Biological Process | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTrinucleotide repeat-containing gene 6A protein
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8NDV7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Epilepsy, familial adult myoclonic, 6 (FAME6)
- Note
- DescriptionA form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME6 inheritance is autosomal dominant.
- See alsoMIM:618074
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_057251 | 185 | in dbSNP:rs11639856 | |||
Sequence: N → K | ||||||
Mutagenesis | 313 | Does not impair interaction with AGO2; when associated with A-345; A-370; A-420 and A-483. | ||||
Sequence: W → A | ||||||
Mutagenesis | 345 | Does not impair interaction with AGO2; when associated with A-313; A-370; A-420 and A-483. | ||||
Sequence: W → A | ||||||
Mutagenesis | 370 | Does not impair interaction with AGO2; when associated with A-313; A-345; A-420 and A-483. | ||||
Sequence: W → A | ||||||
Mutagenesis | 420 | Does not impair interaction with AGO2; when associated with A-313; A-345; A-370 and A-483. | ||||
Sequence: W → A | ||||||
Mutagenesis | 483 | Does not impair interaction with AGO2; when associated with A-313; A-345; A-370 and A-420. | ||||
Sequence: W → A | ||||||
Natural variant | VAR_057252 | 592 | in dbSNP:rs6497759 | |||
Sequence: A → T | ||||||
Natural variant | VAR_057253 | 788 | in dbSNP:rs3803716 | |||
Sequence: P → S | ||||||
Natural variant | VAR_057254 | 1268 | in dbSNP:rs2112782 | |||
Sequence: E → K |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2,110 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000081980 | 1-1962 | UniProt | Trinucleotide repeat-containing gene 6A protein | |||
Sequence: MRELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQKIKVPEQIKPSVSQPQPANSNNGTSTATSTNNNAKRATANNQQPQQQQQQQQPQQQQPQQQPQPQPQQQQPQQQPQALPRYPREVPPRFRHQEHKQLLKRGQHFPVIAANLGSAVKVLNSQSESSALTNQQPQNNGEVQNSKNQSDINHSTSGSHYENSQRGPVSSTSDSSTNCKNAVVSDLSEKEAWPSAPGSDPELASECMDADSASSSESERNITIMASGNTGGEKDGLRNSTGLGSQNKFVVGSSSNNVGHGSSTGPWGFSHGAIISTCQVSVDAPESKSESSNNRMNAWGTVSSSSNGGLNPSTLNSASNHGAWPVLENNGLALKGPVGSGSSGINIQCSTIGQMPNNQSINSKVSGGSTHGTWGSLQETCESEVSGTQKVSFSGQPQNITTEMTGPNNTTNFMTSSLPNSGSVQNNELPSSNTGAWRVSTMNHPQMQAPSGMNGTSLSHLSNGESKSGGSYGTTWGAYGSNYSGDKCSGPNGQANGDTVNATLMQPGVNGPMGTNFQVNTNKGGGVWESGAANSQSTSWGSGNGANSGGSRRGWGTPAQNTGTNLPSVEWNKLPSNQHSNDSANGNGKTFTNGWKSTEEEDQGSATSQTNEQSSVWAKTGGTVESDGSTESTGRLEEKGTGESQSRDRRKIDQHTLLQSIVNRTDLDPRVLSNSGWGQTPIKQNTAWDTETSPRGERKTDNGTEAWGSSATQTFNSGACIDKTSPNGNDTSSVSGWGDPKPALRWGDSKGSNCQGGWEDDSAATGMVKSNQWGNCKEEKAAWNDSQKNKQGWGDGQKSSQGWSVSASDNWGETSRNNHWGEANKKSSSGGSDSDRSVSGWNELGKTSSFTWGNNINPNNSSGWDESSKPTPSQGWGDPPKSNQSLGWGDSSKPVSSPDWNKQQDIVGSWGIPPATGKPPGTGWLGGPIPAPAKEEEPTGWEEPSPESIRRKMEIDDGTSAWGDPSKYNYKNVNMWNKNVPNGNSRSDQQAQVHQLLTPASAISNKEASSGSGWGEPWGEPSTPATTVDNGTSAWGKPIDSGPSWGEPIAAASSTSTWGSSSVGPQALSKSGPKSMQDGWCGDDMPLPGNRPTGWEEEEDVEIGMWNSNSSQELNSSLNWPPYTKKMSSKGLSGKKRRRERGMMKGGNKQEEAWINPFVKQFSNISFSRDSPEENVQSNKMDLSGGMLQDKRMEIDKHSLNIGDYNRTVGKGPGSRPQISKESSMERNPYFDKDGIVADESQNMQFMSSQSMKLPPSNSALPNQALGSIAGLGMQNLNSVRQNGNPSMFGVGNTAAQPRGMQQPPAQPLSSSQPNLRAQVPPPLLSPQVPVSLLKYAPNNGGLNPLFGPQQVAMLNQLSQLNQLSQISQLQRLLAQQQRAQSQRSVPSGNRPQQDQQGRPLSVQQQMMQQSRQLDPNLLVKQQTPPSQQQPLHQPAMKSFLDNVMPHTTPELQKGPSPINAFSNFPIGLNSNLNVNMDMNSIKEPQSRLRKWTTVDSISVNTSLDQNSSKHGAISSGFRLEESPFVPYDFMNSSTSPASPPGSIGDGWPRAKSPNGSSSVNWPPEFRPGEPWKGYPNIDPETDPYVTPGSVINNLSINTVREVDHLRDRNSGSSSSLNTTLPSTSAWSSIRASNYNVPLSSTAQSTSARNSDSKLTWSPGSVTNTSLAHELWKVPLPPKNITAPSRPPPGLTGQKPPLSTWDNSPLRIGGGWGNSDARYTPGSSWGESSSGRITNWLVLKNLTPQIDGSTLRTLCMQHGPLITFHLNLPHGNALVRYSSKEEVVKAQKSLHMCVLGNTTILAEFASEEEISRFFAQSQSLTPSPGWQSLGSSQSRLGSLDCSHSFSSRTDLNHWNGAGLSGTNCGDLHGTSLWGTPHYSTSLWGPPSSSDPRGISSPSPINAFLSVDHLGGGGESM | |||||||
Modified residue (large scale data) | 164 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 207 | PRIDE | Phosphotyrosine | ||||
Sequence: Y | |||||||
Modified residue (large scale data) | 286 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 603 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 672 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 678 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 726 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 739 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 739 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 771 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 875 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 878 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 878 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 942 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 943 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 991 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 991 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1044 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1209 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1212 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1212 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1217 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1270 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1270 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1372 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1470 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1470 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1495 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 1585 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1585 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1599 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1704 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1750 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1867 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 1869 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1869 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 1890 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1941 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1942 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1944 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Induction
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with AGO1, AGO3 and AGO4 (PubMed:19324964, PubMed:19383768).
Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex (PubMed:21981923).
Interacts with ZC3H12A (PubMed:26134560).
Interacts with SND1 (PubMed:28546213).
Interacts with GARRE1 (PubMed:29395067).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8NDV7 | AGO1 Q9UL18 | 8 | EBI-2269715, EBI-527363 | |
BINARY | Q8NDV7 | AGO2 Q9UKV8 | 23 | EBI-2269715, EBI-528269 | |
BINARY | Q8NDV7 | AGO3 Q9H9G7 | 5 | EBI-2269715, EBI-2267883 | |
BINARY | Q8NDV7 | AGO4 Q9HCK5 | 5 | EBI-2269715, EBI-2269696 | |
BINARY | Q8NDV7 | CNOT1 A5YKK6 | 2 | EBI-2269715, EBI-1222758 | |
BINARY | Q8NDV7 | PABPC1 P11940 | 3 | EBI-2269715, EBI-81531 | |
BINARY | Q8NDV7 | PAN3 Q58A45 | 2 | EBI-2269715, EBI-2513054 | |
BINARY | Q8NDV7 | TRIP13 Q15645 | 3 | EBI-2269715, EBI-358993 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region, coiled coil, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-54 | Basic and acidic residues | ||||
Sequence: MRELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQKIK | ||||||
Region | 1-152 | Disordered | ||||
Sequence: MRELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQKIKVPEQIKPSVSQPQPANSNNGTSTATSTNNNAKRATANNQQPQQQQQQQQPQQQQPQQQPQPQPQQQQPQQQPQALPRYPREVPPRFRHQEHKQLLKRG | ||||||
Region | 1-932 | Interaction with argonaute family proteins | ||||
Sequence: MRELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQKIKVPEQIKPSVSQPQPANSNNGTSTATSTNNNAKRATANNQQPQQQQQQQQPQQQQPQQQPQPQPQQQQPQQQPQALPRYPREVPPRFRHQEHKQLLKRGQHFPVIAANLGSAVKVLNSQSESSALTNQQPQNNGEVQNSKNQSDINHSTSGSHYENSQRGPVSSTSDSSTNCKNAVVSDLSEKEAWPSAPGSDPELASECMDADSASSSESERNITIMASGNTGGEKDGLRNSTGLGSQNKFVVGSSSNNVGHGSSTGPWGFSHGAIISTCQVSVDAPESKSESSNNRMNAWGTVSSSSNGGLNPSTLNSASNHGAWPVLENNGLALKGPVGSGSSGINIQCSTIGQMPNNQSINSKVSGGSTHGTWGSLQETCESEVSGTQKVSFSGQPQNITTEMTGPNNTTNFMTSSLPNSGSVQNNELPSSNTGAWRVSTMNHPQMQAPSGMNGTSLSHLSNGESKSGGSYGTTWGAYGSNYSGDKCSGPNGQANGDTVNATLMQPGVNGPMGTNFQVNTNKGGGVWESGAANSQSTSWGSGNGANSGGSRRGWGTPAQNTGTNLPSVEWNKLPSNQHSNDSANGNGKTFTNGWKSTEEEDQGSATSQTNEQSSVWAKTGGTVESDGSTESTGRLEEKGTGESQSRDRRKIDQHTLLQSIVNRTDLDPRVLSNSGWGQTPIKQNTAWDTETSPRGERKTDNGTEAWGSSATQTFNSGACIDKTSPNGNDTSSVSGWGDPKPALRWGDSKGSNCQGGWEDDSAATGMVKSNQWGNCKEEKAAWNDSQKNKQGWGDGQKSSQGWSVSASDNWGETSRNNHWGEANKKSSSGGSDSDRSVSGWNELGKTSSFTWGNNINPNNSSGWDESSKPTPSQGWGDPPKSNQSL | ||||||
Coiled coil | 7-54 | |||||
Sequence: KATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQKIK | ||||||
Compositional bias | 58-114 | Polar residues | ||||
Sequence: QIKPSVSQPQPANSNNGTSTATSTNNNAKRATANNQQPQQQQQQQQPQQQQPQQQPQ | ||||||
Compositional bias | 172-230 | Polar residues | ||||
Sequence: QSESSALTNQQPQNNGEVQNSKNQSDINHSTSGSHYENSQRGPVSSTSDSSTNCKNAVV | ||||||
Region | 172-293 | Disordered | ||||
Sequence: QSESSALTNQQPQNNGEVQNSKNQSDINHSTSGSHYENSQRGPVSSTSDSSTNCKNAVVSDLSEKEAWPSAPGSDPELASECMDADSASSSESERNITIMASGNTGGEKDGLRNSTGLGSQN | ||||||
Region | 254-503 | Sufficient for interaction with AGO1, AGO3 and AGO4 | ||||
Sequence: MDADSASSSESERNITIMASGNTGGEKDGLRNSTGLGSQNKFVVGSSSNNVGHGSSTGPWGFSHGAIISTCQVSVDAPESKSESSNNRMNAWGTVSSSSNGGLNPSTLNSASNHGAWPVLENNGLALKGPVGSGSSGINIQCSTIGQMPNNQSINSKVSGGSTHGTWGSLQETCESEVSGTQKVSFSGQPQNITTEMTGPNNTTNFMTSSLPNSGSVQNNELPSSNTGAWRVSTMNHPQMQAPSGMNGTS | ||||||
Compositional bias | 255-293 | Polar residues | ||||
Sequence: DADSASSSESERNITIMASGNTGGEKDGLRNSTGLGSQN | ||||||
Region | 270-346 | Sufficient for interaction with AGO2 | ||||
Sequence: IMASGNTGGEKDGLRNSTGLGSQNKFVVGSSSNNVGHGSSTGPWGFSHGAIISTCQVSVDAPESKSESSNNRMNAWG | ||||||
Region | 318-399 | Sufficient for interaction with AGO2 | ||||
Sequence: GAIISTCQVSVDAPESKSESSNNRMNAWGTVSSSSNGGLNPSTLNSASNHGAWPVLENNGLALKGPVGSGSSGINIQCSTIG | ||||||
Region | 340-439 | Sufficient for interaction with AGO2 | ||||
Sequence: NRMNAWGTVSSSSNGGLNPSTLNSASNHGAWPVLENNGLALKGPVGSGSSGINIQCSTIGQMPNNQSINSKVSGGSTHGTWGSLQETCESEVSGTQKVSF | ||||||
Region | 409-495 | Sufficient for interaction with AGO2 | ||||
Sequence: SKVSGGSTHGTWGSLQETCESEVSGTQKVSFSGQPQNITTEMTGPNNTTNFMTSSLPNSGSVQNNELPSSNTGAWRVSTMNHPQMQA | ||||||
Region | 435-454 | Disordered | ||||
Sequence: QKVSFSGQPQNITTEMTGPN | ||||||
Region | 494-516 | Disordered | ||||
Sequence: QAPSGMNGTSLSHLSNGESKSGG | ||||||
Region | 502-751 | Sufficient for interaction with AGO2 | ||||
Sequence: TSLSHLSNGESKSGGSYGTTWGAYGSNYSGDKCSGPNGQANGDTVNATLMQPGVNGPMGTNFQVNTNKGGGVWESGAANSQSTSWGSGNGANSGGSRRGWGTPAQNTGTNLPSVEWNKLPSNQHSNDSANGNGKTFTNGWKSTEEEDQGSATSQTNEQSSVWAKTGGTVESDGSTESTGRLEEKGTGESQSRDRRKIDQHTLLQSIVNRTDLDPRVLSNSGWGQTPIKQNTAWDTETSPRGERKTDNGTE | ||||||
Compositional bias | 560-676 | Polar residues | ||||
Sequence: GTNFQVNTNKGGGVWESGAANSQSTSWGSGNGANSGGSRRGWGTPAQNTGTNLPSVEWNKLPSNQHSNDSANGNGKTFTNGWKSTEEEDQGSATSQTNEQSSVWAKTGGTVESDGST | ||||||
Region | 560-699 | Disordered | ||||
Sequence: GTNFQVNTNKGGGVWESGAANSQSTSWGSGNGANSGGSRRGWGTPAQNTGTNLPSVEWNKLPSNQHSNDSANGNGKTFTNGWKSTEEEDQGSATSQTNEQSSVWAKTGGTVESDGSTESTGRLEEKGTGESQSRDRRKID | ||||||
Region | 566-1343 | Sufficient for interaction with AGO1 and AGO4 | ||||
Sequence: NTNKGGGVWESGAANSQSTSWGSGNGANSGGSRRGWGTPAQNTGTNLPSVEWNKLPSNQHSNDSANGNGKTFTNGWKSTEEEDQGSATSQTNEQSSVWAKTGGTVESDGSTESTGRLEEKGTGESQSRDRRKIDQHTLLQSIVNRTDLDPRVLSNSGWGQTPIKQNTAWDTETSPRGERKTDNGTEAWGSSATQTFNSGACIDKTSPNGNDTSSVSGWGDPKPALRWGDSKGSNCQGGWEDDSAATGMVKSNQWGNCKEEKAAWNDSQKNKQGWGDGQKSSQGWSVSASDNWGETSRNNHWGEANKKSSSGGSDSDRSVSGWNELGKTSSFTWGNNINPNNSSGWDESSKPTPSQGWGDPPKSNQSLGWGDSSKPVSSPDWNKQQDIVGSWGIPPATGKPPGTGWLGGPIPAPAKEEEPTGWEEPSPESIRRKMEIDDGTSAWGDPSKYNYKNVNMWNKNVPNGNSRSDQQAQVHQLLTPASAISNKEASSGSGWGEPWGEPSTPATTVDNGTSAWGKPIDSGPSWGEPIAAASSTSTWGSSSVGPQALSKSGPKSMQDGWCGDDMPLPGNRPTGWEEEEDVEIGMWNSNSSQELNSSLNWPPYTKKMSSKGLSGKKRRRERGMMKGGNKQEEAWINPFVKQFSNISFSRDSPEENVQSNKMDLSGGMLQDKRMEIDKHSLNIGDYNRTVGKGPGSRPQISKESSMERNPYFDKDGIVADESQNMQFMSSQSMKLPPSNSALPNQALGSIAGLGMQNLNSVRQNGNPSMFGVGNTAAQ | ||||||
Compositional bias | 677-699 | Basic and acidic residues | ||||
Sequence: ESTGRLEEKGTGESQSRDRRKID | ||||||
Compositional bias | 718-737 | Polar residues | ||||
Sequence: LSNSGWGQTPIKQNTAWDTE | ||||||
Region | 718-1141 | Disordered | ||||
Sequence: LSNSGWGQTPIKQNTAWDTETSPRGERKTDNGTEAWGSSATQTFNSGACIDKTSPNGNDTSSVSGWGDPKPALRWGDSKGSNCQGGWEDDSAATGMVKSNQWGNCKEEKAAWNDSQKNKQGWGDGQKSSQGWSVSASDNWGETSRNNHWGEANKKSSSGGSDSDRSVSGWNELGKTSSFTWGNNINPNNSSGWDESSKPTPSQGWGDPPKSNQSLGWGDSSKPVSSPDWNKQQDIVGSWGIPPATGKPPGTGWLGGPIPAPAKEEEPTGWEEPSPESIRRKMEIDDGTSAWGDPSKYNYKNVNMWNKNVPNGNSRSDQQAQVHQLLTPASAISNKEASSGSGWGEPWGEPSTPATTVDNGTSAWGKPIDSGPSWGEPIAAASSTSTWGSSSVGPQALSKSGPKSMQDGWCGDDMPLPGNRPTGW | ||||||
Compositional bias | 749-782 | Polar residues | ||||
Sequence: GTEAWGSSATQTFNSGACIDKTSPNGNDTSSVSG | ||||||
Compositional bias | 801-818 | Polar residues | ||||
Sequence: QGGWEDDSAATGMVKSNQ | ||||||
Compositional bias | 832-950 | Polar residues | ||||
Sequence: SQKNKQGWGDGQKSSQGWSVSASDNWGETSRNNHWGEANKKSSSGGSDSDRSVSGWNELGKTSSFTWGNNINPNNSSGWDESSKPTPSQGWGDPPKSNQSLGWGDSSKPVSSPDWNKQQ | ||||||
Compositional bias | 982-1004 | Basic and acidic residues | ||||
Sequence: EEPTGWEEPSPESIRRKMEIDDG | ||||||
Compositional bias | 1011-1057 | Polar residues | ||||
Sequence: PSKYNYKNVNMWNKNVPNGNSRSDQQAQVHQLLTPASAISNKEASSG | ||||||
Region | 1074-1144 | Sufficient for interaction with AGO2 | ||||
Sequence: VDNGTSAWGKPIDSGPSWGEPIAAASSTSTWGSSSVGPQALSKSGPKSMQDGWCGDDMPLPGNRPTGWEEE | ||||||
Compositional bias | 1094-1119 | Polar residues | ||||
Sequence: PIAAASSTSTWGSSSVGPQALSKSGP | ||||||
Compositional bias | 1158-1172 | Polar residues | ||||
Sequence: QELNSSLNWPPYTKK | ||||||
Region | 1158-1196 | Disordered | ||||
Sequence: QELNSSLNWPPYTKKMSSKGLSGKKRRRERGMMKGGNKQ | ||||||
Region | 1249-1272 | Disordered | ||||
Sequence: GDYNRTVGKGPGSRPQISKESSME | ||||||
Compositional bias | 1323-1365 | Polar residues | ||||
Sequence: LNSVRQNGNPSMFGVGNTAAQPRGMQQPPAQPLSSSQPNLRAQ | ||||||
Region | 1323-1370 | Disordered | ||||
Sequence: LNSVRQNGNPSMFGVGNTAAQPRGMQQPPAQPLSSSQPNLRAQVPPPL | ||||||
Region | 1424-1456 | Disordered | ||||
Sequence: QRAQSQRSVPSGNRPQQDQQGRPLSVQQQMMQQ | ||||||
Region | 1577-1635 | Disordered | ||||
Sequence: MNSSTSPASPPGSIGDGWPRAKSPNGSSSVNWPPEFRPGEPWKGYPNIDPETDPYVTPG | ||||||
Region | 1604-1622 | PABPC1-interacting motif-2 (PAM2) | ||||
Sequence: SSVNWPPEFRPGEPWKGYP | ||||||
Region | 1670-1962 | Sufficient for interaction with AGO2 | ||||
Sequence: TSAWSSIRASNYNVPLSSTAQSTSARNSDSKLTWSPGSVTNTSLAHELWKVPLPPKNITAPSRPPPGLTGQKPPLSTWDNSPLRIGGGWGNSDARYTPGSSWGESSSGRITNWLVLKNLTPQIDGSTLRTLCMQHGPLITFHLNLPHGNALVRYSSKEEVVKAQKSLHMCVLGNTTILAEFASEEEISRFFAQSQSLTPSPGWQSLGSSQSRLGSLDCSHSFSSRTDLNHWNGAGLSGTNCGDLHGTSLWGTPHYSTSLWGPPSSSDPRGISSPSPINAFLSVDHLGGGGESM | ||||||
Region | 1724-1749 | Disordered | ||||
Sequence: PKNITAPSRPPPGLTGQKPPLSTWDN | ||||||
Compositional bias | 1726-1740 | Pro residues | ||||
Sequence: NITAPSRPPPGLTGQ | ||||||
Domain | 1781-1853 | RRM | ||||
Sequence: NWLVLKNLTPQIDGSTLRTLCMQHGPLITFHLNLPHGNALVRYSSKEEVVKAQKSLHMCVLGNTTILAEFASE |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 6 isoforms produced by Alternative splicing.
Q8NDV7-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsTNGW1
- Length1,962
- Mass (Da)210,297
- Last updated2010-05-18 v2
- Checksum963C054628E18592
Q8NDV7-2
- Name2
- Differences from canonical
- 1-253: Missing
Q8NDV7-3
- Name3
- Differences from canonical
- 1-1232: Missing
- 1280-1328: Missing
- 1611-1962: Missing
Q8NDV7-4
- Name4
- Differences from canonical
- 1-1801: Missing
Q8NDV7-5
- Name5
- Differences from canonical
- 1-54: MRELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQKIK → MAYFGGTLYWLIFSTPFLLLGL
Q8NDV7-6
- Name6
- Differences from canonical
- 1280-1328: Missing
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-54 | Basic and acidic residues | ||||
Sequence: MRELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQKIK | ||||||
Alternative sequence | VSP_013295 | 1-54 | in isoform 5 | |||
Sequence: MRELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQKIK → MAYFGGTLYWLIFSTPFLLLGL | ||||||
Alternative sequence | VSP_013294 | 1-253 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_037287 | 1-1232 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_013292 | 1-1801 | in isoform 4 | |||
Sequence: Missing | ||||||
Sequence conflict | 31-34 | in Ref. 2; CAD37348 | ||||
Sequence: KKKK → TEKE | ||||||
Compositional bias | 58-114 | Polar residues | ||||
Sequence: QIKPSVSQPQPANSNNGTSTATSTNNNAKRATANNQQPQQQQQQQQPQQQQPQQQPQ | ||||||
Compositional bias | 172-230 | Polar residues | ||||
Sequence: QSESSALTNQQPQNNGEVQNSKNQSDINHSTSGSHYENSQRGPVSSTSDSSTNCKNAVV | ||||||
Compositional bias | 255-293 | Polar residues | ||||
Sequence: DADSASSSESERNITIMASGNTGGEKDGLRNSTGLGSQN | ||||||
Compositional bias | 560-676 | Polar residues | ||||
Sequence: GTNFQVNTNKGGGVWESGAANSQSTSWGSGNGANSGGSRRGWGTPAQNTGTNLPSVEWNKLPSNQHSNDSANGNGKTFTNGWKSTEEEDQGSATSQTNEQSSVWAKTGGTVESDGST | ||||||
Compositional bias | 677-699 | Basic and acidic residues | ||||
Sequence: ESTGRLEEKGTGESQSRDRRKID | ||||||
Compositional bias | 718-737 | Polar residues | ||||
Sequence: LSNSGWGQTPIKQNTAWDTE | ||||||
Compositional bias | 749-782 | Polar residues | ||||
Sequence: GTEAWGSSATQTFNSGACIDKTSPNGNDTSSVSG | ||||||
Compositional bias | 801-818 | Polar residues | ||||
Sequence: QGGWEDDSAATGMVKSNQ | ||||||
Compositional bias | 832-950 | Polar residues | ||||
Sequence: SQKNKQGWGDGQKSSQGWSVSASDNWGETSRNNHWGEANKKSSSGGSDSDRSVSGWNELGKTSSFTWGNNINPNNSSGWDESSKPTPSQGWGDPPKSNQSLGWGDSSKPVSSPDWNKQQ | ||||||
Compositional bias | 982-1004 | Basic and acidic residues | ||||
Sequence: EEPTGWEEPSPESIRRKMEIDDG | ||||||
Compositional bias | 1011-1057 | Polar residues | ||||
Sequence: PSKYNYKNVNMWNKNVPNGNSRSDQQAQVHQLLTPASAISNKEASSG | ||||||
Compositional bias | 1094-1119 | Polar residues | ||||
Sequence: PIAAASSTSTWGSSSVGPQALSKSGP | ||||||
Compositional bias | 1158-1172 | Polar residues | ||||
Sequence: QELNSSLNWPPYTKK | ||||||
Alternative sequence | VSP_037288 | 1280-1328 | in isoform 3 and isoform 6 | |||
Sequence: Missing | ||||||
Compositional bias | 1323-1365 | Polar residues | ||||
Sequence: LNSVRQNGNPSMFGVGNTAAQPRGMQQPPAQPLSSSQPNLRAQ | ||||||
Sequence conflict | 1375 | in Ref. 3; CAD28525 | ||||
Sequence: V → VV | ||||||
Alternative sequence | VSP_037289 | 1611-1962 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 1704 | in Ref. 8; BAA91899 | ||||
Sequence: S → F | ||||||
Compositional bias | 1726-1740 | Pro residues | ||||
Sequence: NITAPSRPPPGLTGQ |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY035864 EMBL· GenBank· DDBJ | AAK62026.1 EMBL· GenBank· DDBJ | mRNA | ||
AJ492221 EMBL· GenBank· DDBJ | CAD37348.1 EMBL· GenBank· DDBJ | mRNA | ||
AL713750 EMBL· GenBank· DDBJ | CAD28525.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AL833757 EMBL· GenBank· DDBJ | CAH56236.1 EMBL· GenBank· DDBJ | mRNA | ||
AC002565 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC008731 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC024324 EMBL· GenBank· DDBJ | AAH24324.2 EMBL· GenBank· DDBJ | mRNA | ||
BC068209 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
U80739 EMBL· GenBank· DDBJ | AAB91438.1 EMBL· GenBank· DDBJ | mRNA | ||
AB040893 EMBL· GenBank· DDBJ | BAA95984.1 EMBL· GenBank· DDBJ | mRNA | ||
AK001773 EMBL· GenBank· DDBJ | BAA91899.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |