Q8NCS7 · CTL5_HUMAN

  • Protein
    Choline transporter-like protein 5
  • Gene
    SLC44A5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Choline/H+ antiporter.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Molecular Functionantiporter activity
Molecular Functioncholine transmembrane transporter activity
Molecular Functiontransmembrane transporter activity
Biological Processcholine transport
Biological Processphosphatidylcholine biosynthetic process
Biological Processtransmembrane transport

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Choline transporter-like protein 5
  • Alternative names
    • Solute carrier family 44 member 5

Gene names

    • Name
      SLC44A5
    • Synonyms
      CTL5

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8NCS7
  • Secondary accessions
    • A0A0A0MRP1
    • B5MCU3
    • Q4G0K0
    • Q8NA44
    • Q8NB86

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-38Cytoplasmic
Transmembrane39-59Helical
Topological domain60-242Extracellular
Transmembrane243-263Helical
Topological domain264-265Cytoplasmic
Transmembrane266-286Helical
Topological domain287-325Extracellular
Transmembrane326-346Helical
Topological domain347-351Cytoplasmic
Transmembrane352-372Helical
Topological domain373-374Extracellular
Transmembrane375-395Helical
Topological domain396-460Cytoplasmic
Transmembrane461-481Helical
Topological domain482-515Extracellular
Transmembrane516-536Helical
Topological domain537-610Cytoplasmic
Transmembrane611-631Helical
Topological domain632-649Extracellular
Transmembrane650-670Helical
Topological domain671-719Cytoplasmic

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 821 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00001917261-719Choline transporter-like protein 5
Glycosylation88N-linked (GlcNAc...) asparagine
Glycosylation190N-linked (GlcNAc...) asparagine
Glycosylation314N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Structure

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-23Basic and acidic residues
Region1-24Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q8NCS7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    A
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    719
  • Mass (Da)
    81,694
  • Last updated
    2018-09-12 v5
  • Checksum
    FF5B57849397F031
MNDTEKPADTPSEEEDFGDPRTYDPDFKGPVANRSCTDVLCCMIFLLCIIGYIVLGLVAWVHGDPRRAAYPTDSQGHFCGQKGTPNENKTILFYFNLLRCTSPSVLLNLQCPTTQICVSKCPEKFLTYVEMQLLYTKDKSYWEDYRQFCKTTAKPVKSLTQLLLDDDCPTAIFPSKPFLQRCFPDFSTKNGTLTIGSKMMFQDGNGGTRSVVELGIAANGINKLLDAKSLGLKVFEDYARTWYWILIGLTIAMVLSWIFLILLRFIAGCLFWVFMIGVIGIIGYGIWHCYQQYTNLQERPSSVLTIYDIGIQTNISMYFELQQTWFTFMIILCIIEVIVILMLIFLRNRIRVAIILLKEGSKAIGYVPSTLVYPALTFILLSICICYWVVTAVFLATSGVPVYKVIAPGGHCIHENQTCDPEIFNTTEIAKACPGALCNFAFYGGKSLYHQYIPTFHVYNLFVFLWLINFVIALGQCALAGAFATYYWAMKKPDDIPRYPLFTAFGRAIRYHTGSLAFGSLIIALIQMFKIVLEYLDHRLKRTQNTLSKFLQCCLRCCFWCLENAIKFLNRNAYIMIAIYGRNFCRSAKDAFNLLMRNVLKVAVTDEVTYFVLFLGKLLVAGSIGVLAFLFFTQRLPVIAQGPASLNYYWVPLLTVIFGSYLIAHGFFSVYAMCVETIFICFCEDLERNDGSTEKPYFVTPNLHGILIKKQLVPQKQKE

Q8NCS7-4

  • Name
    2
  • Synonyms
    B
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 683-719: CEDLERNDGSTEKPYFVTPNLHGILIKKQLVPQKQKE → LEDLERNDGSTARPYYVSQPLLKIFQEENPQTRKQ

Q8NCS7-5

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-42: Missing
    • 683-719: CEDLERNDGSTEKPYFVTPNLHGILIKKQLVPQKQKE → LEDLERNDGSTARPYYVSQPLLKIFQEENPQTRKQ

Sequence caution

The sequence BAC03655.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias1-23Basic and acidic residues
Alternative sequenceVSP_0598021-42in isoform 3
Sequence conflict501in Ref. 1; BAC04084
Sequence conflict647in Ref. 4; AAH28743
Alternative sequenceVSP_059803683-719in isoform 2 and isoform 3
Sequence conflict688in Ref. 1; BAC03655

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK091400
EMBL· GenBank· DDBJ
BAC03655.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK093170
EMBL· GenBank· DDBJ
BAC04084.1
EMBL· GenBank· DDBJ
mRNA
AC118550
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC093156
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC107627
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC118990
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL096829
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KC876880
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471059
EMBL· GenBank· DDBJ
EAX06402.1
EMBL· GenBank· DDBJ
Genomic DNA
BC028743
EMBL· GenBank· DDBJ
AAH28743.1
EMBL· GenBank· DDBJ
mRNA
BC034580
EMBL· GenBank· DDBJ
AAH34580.1
EMBL· GenBank· DDBJ
mRNA
BC051740
EMBL· GenBank· DDBJ
AAH51740.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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