Q8NCS7 · CTL5_HUMAN
- ProteinCholine transporter-like protein 5
- GeneSLC44A5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids719 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Choline/H+ antiporter.
Catalytic activity
- choline(out) + n H+(in) = choline(in) + n H+(out)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | antiporter activity | |
Molecular Function | choline transmembrane transporter activity | |
Molecular Function | transmembrane transporter activity | |
Biological Process | choline transport | |
Biological Process | phosphatidylcholine biosynthetic process | |
Biological Process | transmembrane transport |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameCholine transporter-like protein 5
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8NCS7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-38 | Cytoplasmic | ||||
Sequence: MNDTEKPADTPSEEEDFGDPRTYDPDFKGPVANRSCTD | ||||||
Transmembrane | 39-59 | Helical | ||||
Sequence: VLCCMIFLLCIIGYIVLGLVA | ||||||
Topological domain | 60-242 | Extracellular | ||||
Sequence: WVHGDPRRAAYPTDSQGHFCGQKGTPNENKTILFYFNLLRCTSPSVLLNLQCPTTQICVSKCPEKFLTYVEMQLLYTKDKSYWEDYRQFCKTTAKPVKSLTQLLLDDDCPTAIFPSKPFLQRCFPDFSTKNGTLTIGSKMMFQDGNGGTRSVVELGIAANGINKLLDAKSLGLKVFEDYARTW | ||||||
Transmembrane | 243-263 | Helical | ||||
Sequence: YWILIGLTIAMVLSWIFLILL | ||||||
Topological domain | 264-265 | Cytoplasmic | ||||
Sequence: RF | ||||||
Transmembrane | 266-286 | Helical | ||||
Sequence: IAGCLFWVFMIGVIGIIGYGI | ||||||
Topological domain | 287-325 | Extracellular | ||||
Sequence: WHCYQQYTNLQERPSSVLTIYDIGIQTNISMYFELQQTW | ||||||
Transmembrane | 326-346 | Helical | ||||
Sequence: FTFMIILCIIEVIVILMLIFL | ||||||
Topological domain | 347-351 | Cytoplasmic | ||||
Sequence: RNRIR | ||||||
Transmembrane | 352-372 | Helical | ||||
Sequence: VAIILLKEGSKAIGYVPSTLV | ||||||
Topological domain | 373-374 | Extracellular | ||||
Sequence: YP | ||||||
Transmembrane | 375-395 | Helical | ||||
Sequence: ALTFILLSICICYWVVTAVFL | ||||||
Topological domain | 396-460 | Cytoplasmic | ||||
Sequence: ATSGVPVYKVIAPGGHCIHENQTCDPEIFNTTEIAKACPGALCNFAFYGGKSLYHQYIPTFHVYN | ||||||
Transmembrane | 461-481 | Helical | ||||
Sequence: LFVFLWLINFVIALGQCALAG | ||||||
Topological domain | 482-515 | Extracellular | ||||
Sequence: AFATYYWAMKKPDDIPRYPLFTAFGRAIRYHTGS | ||||||
Transmembrane | 516-536 | Helical | ||||
Sequence: LAFGSLIIALIQMFKIVLEYL | ||||||
Topological domain | 537-610 | Cytoplasmic | ||||
Sequence: DHRLKRTQNTLSKFLQCCLRCCFWCLENAIKFLNRNAYIMIAIYGRNFCRSAKDAFNLLMRNVLKVAVTDEVTY | ||||||
Transmembrane | 611-631 | Helical | ||||
Sequence: FVLFLGKLLVAGSIGVLAFLF | ||||||
Topological domain | 632-649 | Extracellular | ||||
Sequence: FTQRLPVIAQGPASLNYY | ||||||
Transmembrane | 650-670 | Helical | ||||
Sequence: WVPLLTVIFGSYLIAHGFFSV | ||||||
Topological domain | 671-719 | Cytoplasmic | ||||
Sequence: YAMCVETIFICFCEDLERNDGSTEKPYFVTPNLHGILIKKQLVPQKQKE |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 821 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000191726 | 1-719 | Choline transporter-like protein 5 | |||
Sequence: MNDTEKPADTPSEEEDFGDPRTYDPDFKGPVANRSCTDVLCCMIFLLCIIGYIVLGLVAWVHGDPRRAAYPTDSQGHFCGQKGTPNENKTILFYFNLLRCTSPSVLLNLQCPTTQICVSKCPEKFLTYVEMQLLYTKDKSYWEDYRQFCKTTAKPVKSLTQLLLDDDCPTAIFPSKPFLQRCFPDFSTKNGTLTIGSKMMFQDGNGGTRSVVELGIAANGINKLLDAKSLGLKVFEDYARTWYWILIGLTIAMVLSWIFLILLRFIAGCLFWVFMIGVIGIIGYGIWHCYQQYTNLQERPSSVLTIYDIGIQTNISMYFELQQTWFTFMIILCIIEVIVILMLIFLRNRIRVAIILLKEGSKAIGYVPSTLVYPALTFILLSICICYWVVTAVFLATSGVPVYKVIAPGGHCIHENQTCDPEIFNTTEIAKACPGALCNFAFYGGKSLYHQYIPTFHVYNLFVFLWLINFVIALGQCALAGAFATYYWAMKKPDDIPRYPLFTAFGRAIRYHTGSLAFGSLIIALIQMFKIVLEYLDHRLKRTQNTLSKFLQCCLRCCFWCLENAIKFLNRNAYIMIAIYGRNFCRSAKDAFNLLMRNVLKVAVTDEVTYFVLFLGKLLVAGSIGVLAFLFFTQRLPVIAQGPASLNYYWVPLLTVIFGSYLIAHGFFSVYAMCVETIFICFCEDLERNDGSTEKPYFVTPNLHGILIKKQLVPQKQKE | ||||||
Glycosylation | 88 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 190 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 314 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8NCS7 | BDNF P23560-2 | 3 | EBI-21504521, EBI-12275524 | |
BINARY | Q8NCS7 | CBX5 P45973 | 3 | EBI-21504521, EBI-78219 | |
BINARY | Q8NCS7 | HTT P42858 | 3 | EBI-21504521, EBI-466029 | |
BINARY | Q8NCS7 | JPH3 Q8WXH2 | 3 | EBI-21504521, EBI-1055254 | |
BINARY | Q8NCS7 | PECAM1 P16284 | 3 | EBI-21504521, EBI-716404 | |
BINARY | Q8NCS7 | RAD23A P54725 | 3 | EBI-21504521, EBI-746453 | |
BINARY | Q8NCS7 | SERPINH1 P50454 | 3 | EBI-21504521, EBI-350723 | |
BINARY | Q8NCS7 | TARDBP Q13148 | 6 | EBI-21504521, EBI-372899 | |
BINARY | Q8NCS7 | TGFBR2 P37173 | 3 | EBI-21504521, EBI-296151 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-23 | Basic and acidic residues | ||||
Sequence: MNDTEKPADTPSEEEDFGDPRTY | ||||||
Region | 1-24 | Disordered | ||||
Sequence: MNDTEKPADTPSEEEDFGDPRTYD |
Sequence similarities
Belongs to the CTL (choline transporter-like) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q8NCS7-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsA
- Length719
- Mass (Da)81,694
- Last updated2018-09-12 v5
- ChecksumFF5B57849397F031
Q8NCS7-4
- Name2
- SynonymsB
- Differences from canonical
- 683-719: CEDLERNDGSTEKPYFVTPNLHGILIKKQLVPQKQKE → LEDLERNDGSTARPYYVSQPLLKIFQEENPQTRKQ
Q8NCS7-5
- Name3
Sequence caution
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-23 | Basic and acidic residues | ||||
Sequence: MNDTEKPADTPSEEEDFGDPRTY | ||||||
Alternative sequence | VSP_059802 | 1-42 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 501 | in Ref. 1; BAC04084 | ||||
Sequence: L → P | ||||||
Sequence conflict | 647 | in Ref. 4; AAH28743 | ||||
Sequence: N → Y | ||||||
Alternative sequence | VSP_059803 | 683-719 | in isoform 2 and isoform 3 | |||
Sequence: CEDLERNDGSTEKPYFVTPNLHGILIKKQLVPQKQKE → LEDLERNDGSTARPYYVSQPLLKIFQEENPQTRKQ | ||||||
Sequence conflict | 688 | in Ref. 1; BAC03655 | ||||
Sequence: R → I |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK091400 EMBL· GenBank· DDBJ | BAC03655.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK093170 EMBL· GenBank· DDBJ | BAC04084.1 EMBL· GenBank· DDBJ | mRNA | ||
AC118550 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC093156 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC107627 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC118990 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL096829 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KC876880 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471059 EMBL· GenBank· DDBJ | EAX06402.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC028743 EMBL· GenBank· DDBJ | AAH28743.1 EMBL· GenBank· DDBJ | mRNA | ||
BC034580 EMBL· GenBank· DDBJ | AAH34580.1 EMBL· GenBank· DDBJ | mRNA | ||
BC051740 EMBL· GenBank· DDBJ | AAH51740.1 EMBL· GenBank· DDBJ | mRNA |