Q8NAA4 · A16L2_HUMAN
- ProteinProtein Atg16l2
- GeneATG16L2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids619 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner.
Miscellaneous
Although ATG16L2 is structurally similar to ATG16L1 and is likewise able to form a complex with the autophagy proteins ATG5 and ATG12, overexpression and knockdown studies in mouse suggest that ATG16L2 is not essential for canonical autophagy.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Atg12-Atg5-Atg16 complex | |
Cellular Component | cytosol | |
Cellular Component | nucleoplasm | |
Cellular Component | phagophore assembly site membrane | |
Biological Process | autophagosome assembly | |
Biological Process | macroautophagy | |
Biological Process | negative stranded viral RNA replication | |
Biological Process | protein transport |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProtein Atg16l2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8NAA4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localizes also to discrete punctae along the ciliary axoneme.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_043605 | 220 | in dbSNP:rs11235604 | |||
Sequence: R → W |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 708 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000337110 | 1-619 | UniProt | Protein Atg16l2 | |||
Sequence: MAGPGVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSVTPTTHQGPWEESELDSDQVPSLVALRVKWQEEEEGLRLVCGEMAYQVVEKGAALGTLESELQQRQSRLAALEARVAQLREARAQQAQQVEEWRAQNAVQRAAYEALRAHVGLREAALRRLQEEARDLLERLVQRKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISEGPDTLGDGMRERRETLALAPEPEPLEKEACEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKRRGHSIGGAPEQRYQIIPVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ | |||||||
Modified residue (large scale data) | 234 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 276 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 278 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 304 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Homooligomer. Heterooligomer with ATG16L1. Interacts with ATG5. Self-oligomerizes to form a 800-kDa complex composed of ATG12-ATG5 and ATG16L2. Interacts with RAB33B.
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 57-78 | Disordered | ||||
Sequence: LQPEPNSVTPTTHQGPWEESEL | ||||||
Compositional bias | 58-73 | Polar residues | ||||
Sequence: QPEPNSVTPTTHQGPW | ||||||
Coiled coil | 116-227 | |||||
Sequence: AALGTLESELQQRQSRLAALEARVAQLREARAQQAQQVEEWRAQNAVQRAAYEALRAHVGLREAALRRLQEEARDLLERLVQRKARAAAERNLRNERRERAKQARVSQELKK | ||||||
Repeat | 334-373 | WD 1 | ||||
Sequence: AHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEAN | ||||||
Repeat | 378-417 | WD 2 | ||||
Sequence: GAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKET | ||||||
Repeat | 420-454 | WD 3 | ||||
Sequence: GHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRA | ||||||
Repeat | 455-498 | WD 4 | ||||
Sequence: YCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQV | ||||||
Repeat | 500-539 | WD 5 | ||||
Sequence: PVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQV | ||||||
Repeat | 546-585 | WD 6 | ||||
Sequence: KCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESR | ||||||
Repeat | 589-619 | WD 7 | ||||
Sequence: PHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ |
Sequence similarities
Belongs to the WD repeat ATG16 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q8NAA4-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length619
- Mass (Da)68,998
- Last updated2008-05-20 v2
- Checksum7F2962AA3C6BB850
Q8NAA4-2
- Name2
- Differences from canonical
- 1-106: Missing
Q8NAA4-3
- Name3
- Differences from canonical
- 276-619: Missing
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H0YGJ8 | H0YGJ8_HUMAN | ATG16L2 | 117 | ||
H0YGE3 | H0YGE3_HUMAN | ATG16L2 | 98 | ||
H0YFC3 | H0YFC3_HUMAN | ATG16L2 | 74 | ||
H0YFG0 | H0YFG0_HUMAN | ATG16L2 | 321 | ||
H0YFZ7 | H0YFZ7_HUMAN | ATG16L2 | 98 | ||
H0YG67 | H0YG67_HUMAN | ATG16L2 | 416 | ||
H0YG45 | H0YG45_HUMAN | ATG16L2 | 397 | ||
H0YF72 | H0YF72_HUMAN | ATG16L2 | 450 | ||
F5GWZ9 | F5GWZ9_HUMAN | ATG16L2 | 164 | ||
F5H7B6 | F5H7B6_HUMAN | ATG16L2 | 106 | ||
F5GWM4 | F5GWM4_HUMAN | ATG16L2 | 121 |
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_033904 | 1-106 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 58-73 | Polar residues | ||||
Sequence: QPEPNSVTPTTHQGPW | ||||||
Sequence conflict | 124 | in Ref. 1; BAC03485 | ||||
Sequence: E → G | ||||||
Sequence conflict | 256 | in Ref. 3; AAH36713 | ||||
Sequence: A → V | ||||||
Alternative sequence | VSP_033905 | 276-619 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 343 | in Ref. 1; BAC03485 | ||||
Sequence: R → G | ||||||
Sequence conflict | 492 | in Ref. 1; BAC04021 | ||||
Sequence: G → E | ||||||
Sequence conflict | 508 | in Ref. 4; CAH56355 | ||||
Sequence: L → R |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK093017 EMBL· GenBank· DDBJ | BAC04021.1 EMBL· GenBank· DDBJ | mRNA | ||
AK090597 EMBL· GenBank· DDBJ | BAC03485.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471076 EMBL· GenBank· DDBJ | EAW74876.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471076 EMBL· GenBank· DDBJ | EAW74874.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC036713 EMBL· GenBank· DDBJ | AAH36713.1 EMBL· GenBank· DDBJ | mRNA | ||
BC137489 EMBL· GenBank· DDBJ | AAI37490.1 EMBL· GenBank· DDBJ | mRNA | ||
BC137490 EMBL· GenBank· DDBJ | AAI37491.1 EMBL· GenBank· DDBJ | mRNA | ||
BC142718 EMBL· GenBank· DDBJ | AAI42719.1 EMBL· GenBank· DDBJ | mRNA | ||
BC146660 EMBL· GenBank· DDBJ | AAI46661.1 EMBL· GenBank· DDBJ | mRNA | ||
AL832974 EMBL· GenBank· DDBJ | CAH56355.1 EMBL· GenBank· DDBJ | mRNA |