Q8NAA4 · A16L2_HUMAN

  • Protein
    Protein Atg16l2
  • Gene
    ATG16L2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner.

Miscellaneous

Although ATG16L2 is structurally similar to ATG16L1 and is likewise able to form a complex with the autophagy proteins ATG5 and ATG12, overexpression and knockdown studies in mouse suggest that ATG16L2 is not essential for canonical autophagy.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentAtg12-Atg5-Atg16 complex
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular Componentphagophore assembly site membrane
Biological Processautophagosome assembly
Biological Processmacroautophagy
Biological Processnegative stranded viral RNA replication
Biological Processprotein transport

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 9.A.15.2.1the autophagy-related phagophore-formation transporter (apt) family

Names & Taxonomy

Protein names

  • Recommended name
    Protein Atg16l2
  • Alternative names
    • APG16-like 2
    • Autophagy-related protein 16-2
    • WD repeat-containing protein 80

Gene names

    • Name
      ATG16L2
    • Synonyms
      WDR80

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8NAA4
  • Secondary accessions
    • A5PL30
    • B2RPK5
    • Q658V4
    • Q6PID3
    • Q8NBG0

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm, cytosol
Note: Localizes also to discrete punctae along the ciliary axoneme.

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_043605220in dbSNP:rs11235604

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 708 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00003371101-619UniProtProtein Atg16l2
Modified residue (large scale data)234PRIDEPhosphoserine
Modified residue (large scale data)276PRIDEPhosphoserine
Modified residue (large scale data)278PRIDEPhosphoserine
Modified residue (large scale data)304PRIDEPhosphoserine

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Homooligomer. Heterooligomer with ATG16L1. Interacts with ATG5. Self-oligomerizes to form a 800-kDa complex composed of ATG12-ATG5 and ATG16L2. Interacts with RAB33B.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias, coiled coil, repeat.

TypeIDPosition(s)Description
Region57-78Disordered
Compositional bias58-73Polar residues
Coiled coil116-227
Repeat334-373WD 1
Repeat378-417WD 2
Repeat420-454WD 3
Repeat455-498WD 4
Repeat500-539WD 5
Repeat546-585WD 6
Repeat589-619WD 7

Sequence similarities

Belongs to the WD repeat ATG16 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q8NAA4-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    619
  • Mass (Da)
    68,998
  • Last updated
    2008-05-20 v2
  • Checksum
    7F2962AA3C6BB850
MAGPGVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSVTPTTHQGPWEESELDSDQVPSLVALRVKWQEEEEGLRLVCGEMAYQVVEKGAALGTLESELQQRQSRLAALEARVAQLREARAQQAQQVEEWRAQNAVQRAAYEALRAHVGLREAALRRLQEEARDLLERLVQRKARAAAERNLRNERRERAKQARVSQELKKAAKRTVSISEGPDTLGDGMRERRETLALAPEPEPLEKEACEKWKRPFRSASATSLTLSHCVDVVKGLLDFKKRRGHSIGGAPEQRYQIIPVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTLEGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQAVTGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGDHIIISGHNDQKIRFWDSRGPHCTQVIPVQGRVTSLSLSHDQLHLLSCSRDNTLKVIDLRVSNIRQVFRADGFKCGSDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVSVDQGRKVVLWQ

Q8NAA4-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8NAA4-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 11 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YGJ8H0YGJ8_HUMANATG16L2117
H0YGE3H0YGE3_HUMANATG16L298
H0YFC3H0YFC3_HUMANATG16L274
H0YFG0H0YFG0_HUMANATG16L2321
H0YFZ7H0YFZ7_HUMANATG16L298
H0YG67H0YG67_HUMANATG16L2416
H0YG45H0YG45_HUMANATG16L2397
H0YF72H0YF72_HUMANATG16L2450
F5GWZ9F5GWZ9_HUMANATG16L2164
F5H7B6F5H7B6_HUMANATG16L2106
F5GWM4F5GWM4_HUMANATG16L2121

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0339041-106in isoform 2
Compositional bias58-73Polar residues
Sequence conflict124in Ref. 1; BAC03485
Sequence conflict256in Ref. 3; AAH36713
Alternative sequenceVSP_033905276-619in isoform 3
Sequence conflict343in Ref. 1; BAC03485
Sequence conflict492in Ref. 1; BAC04021
Sequence conflict508in Ref. 4; CAH56355

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK093017
EMBL· GenBank· DDBJ
BAC04021.1
EMBL· GenBank· DDBJ
mRNA
AK090597
EMBL· GenBank· DDBJ
BAC03485.1
EMBL· GenBank· DDBJ
mRNA
CH471076
EMBL· GenBank· DDBJ
EAW74876.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471076
EMBL· GenBank· DDBJ
EAW74874.1
EMBL· GenBank· DDBJ
Genomic DNA
BC036713
EMBL· GenBank· DDBJ
AAH36713.1
EMBL· GenBank· DDBJ
mRNA
BC137489
EMBL· GenBank· DDBJ
AAI37490.1
EMBL· GenBank· DDBJ
mRNA
BC137490
EMBL· GenBank· DDBJ
AAI37491.1
EMBL· GenBank· DDBJ
mRNA
BC142718
EMBL· GenBank· DDBJ
AAI42719.1
EMBL· GenBank· DDBJ
mRNA
BC146660
EMBL· GenBank· DDBJ
AAI46661.1
EMBL· GenBank· DDBJ
mRNA
AL832974
EMBL· GenBank· DDBJ
CAH56355.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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