Q8N995 · Q8N995_HUMAN
- ProteinHydroxymethylglutaryl-CoA synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids509 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.
Catalytic activity
- acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-hydroxy-3-methylglutaryl-CoA + CoA + H+
Pathway
Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 95 | Proton donor/acceptor | ||||
Sequence: E | ||||||
Binding site | 156 | CoA (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 210 | CoA (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Active site | 253 | Proton donor/acceptor | ||||
Sequence: H | ||||||
Binding site | 258 | CoA (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 262 | CoA (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | hydroxymethylglutaryl-CoA synthase activity | |
Biological Process | acetyl-CoA metabolic process | |
Biological Process | cholesterol biosynthetic process | |
Biological Process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHydroxymethylglutaryl-CoA synthase
- EC number
- Short namesHMG-CoA synthase
- Alternative names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8N995
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 13-175 | Hydroxymethylglutaryl-coenzyme A synthase N-terminal | ||||
Sequence: WPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAP | ||||||
Domain | 176-458 | Hydroxymethylglutaryl-coenzyme A synthase C-terminal | ||||
Sequence: LIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARR | ||||||
Region | 481-509 | Disordered | ||||
Sequence: HIPSPAKKVPRLPATAAEPEAAVISNGEH |
Sequence similarities
Belongs to the thiolase-like superfamily. HMG-CoA synthase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length509
- Mass (Da)56,238
- Last updated2002-10-01 v1
- Checksum75AAEB049EAB1460