Q8N995 · Q8N995_HUMAN

  • Protein
    Hydroxymethylglutaryl-CoA synthase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    2/5

Function

function

Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.

Catalytic activity

Pathway

Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.

Features

Showing features for active site, binding site.

150950100150200250300350400450500
TypeIDPosition(s)Description
Active site95Proton donor/acceptor
Binding site156CoA (UniProtKB | ChEBI)
Binding site210CoA (UniProtKB | ChEBI)
Active site253Proton donor/acceptor
Binding site258CoA (UniProtKB | ChEBI)
Binding site262CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionhydroxymethylglutaryl-CoA synthase activity
Biological Processacetyl-CoA metabolic process
Biological Processcholesterol biosynthetic process
Biological Processfarnesyl diphosphate biosynthetic process, mevalonate pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hydroxymethylglutaryl-CoA synthase
  • EC number
  • Short names
    HMG-CoA synthase
  • Alternative names
    • 3-hydroxy-3-methylglutaryl coenzyme A synthase

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8N995

PTM/Processing

Proteomic databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain13-175Hydroxymethylglutaryl-coenzyme A synthase N-terminal
Domain176-458Hydroxymethylglutaryl-coenzyme A synthase C-terminal
Region481-509Disordered

Sequence similarities

Belongs to the thiolase-like superfamily. HMG-CoA synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    509
  • Mass (Da)
    56,238
  • Last updated
    2002-10-01 v1
  • Checksum
    75AAEB049EAB1460
MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEGVGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK095492
EMBL· GenBank· DDBJ
BAC04559.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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