Q8N972 · ZN709_HUMAN
- ProteinZinc finger protein 709
- GeneZNF709
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids641 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
May be involved in transcriptional regulation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II transcription regulatory region sequence-specific DNA binding | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
The subsequence DSVVFEDVAVNFTQEEWALLGPSQKKLYRDVMQETFVNLASIGENWEEKNIEDHKNQGRKLRSHMVERLCERKEGSQFGE, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein 709
Gene names
- Community suggested namesZNF709
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8N972
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000230312 | 1-641 | Zinc finger protein 709 | |||
Sequence: MDSVVFEDVAVNFTQEEWALLGPSQKKLYRDVMQETFVNLASIGENWEEKNIEDHKNQGRKLRSHMVERLCERKEGSQFGETISQTPNPKPNKKTFTRVKPYECSVCGKDYMCHSSLNRHMRSHTEHRSYEYHKYGEKSYECKECGKRFSFRSSFRIHERTHTGEKPYKCKQCGKAFSWPSSFQIHERTHTGEKPYECKECGKAFIYHTTFRGHMRMHTGEKPYKCKECGKTFSHPSSFRNHERTHSGEKPYECKQCGKAFRYYQTFQIHERTHTGEKPYQCKQCGKALSCPTSFRSHERIHTGEKPYKCKKCGKAFSFPSSFRKHERIHTGEKPYDCKECGKAFISLPSYRRHMIMHTGNGPYKCKECGKAFDCPSSFQIHERTHTGEKPYECKQCGKAFSCSSSFRMHERTHTGEKPHECKQCGKAFSCSSSVRIHERTHTGEKPYECKQCGKAFSCSSSFRMHERIHTGEKPYECKQCGKAFSFSSSFRMHERTHTGEKPYECKQCGKAFSCSSSFRMHERTHTGEKPYECKQCGKAFSCSSSIRIHERTHTGEKPYECKQCGKAFSCSSSVRMHERTHTGVKPYECKQCDKAFSCSRSFRIHERTHTGEKPYACQQCGKAFKCSRSFRIHERVHSGE |
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-75 | KRAB | ||||
Sequence: VVFEDVAVNFTQEEWALLGPSQKKLYRDVMQETFVNLASIGENWEEKNIEDHKNQGRKLRSHMVERLCERKE | ||||||
Zinc finger | 102-124 | C2H2-type 1 | ||||
Sequence: YECSVCGKDYMCHSSLNRHMRSH | ||||||
Zinc finger | 140-162 | C2H2-type 2 | ||||
Sequence: YECKECGKRFSFRSSFRIHERTH | ||||||
Zinc finger | 168-190 | C2H2-type 3 | ||||
Sequence: YKCKQCGKAFSWPSSFQIHERTH | ||||||
Zinc finger | 196-218 | C2H2-type 4 | ||||
Sequence: YECKECGKAFIYHTTFRGHMRMH | ||||||
Zinc finger | 224-246 | C2H2-type 5 | ||||
Sequence: YKCKECGKTFSHPSSFRNHERTH | ||||||
Zinc finger | 252-274 | C2H2-type 6 | ||||
Sequence: YECKQCGKAFRYYQTFQIHERTH | ||||||
Zinc finger | 280-302 | C2H2-type 7 | ||||
Sequence: YQCKQCGKALSCPTSFRSHERIH | ||||||
Zinc finger | 308-330 | C2H2-type 8 | ||||
Sequence: YKCKKCGKAFSFPSSFRKHERIH | ||||||
Zinc finger | 336-358 | C2H2-type 9 | ||||
Sequence: YDCKECGKAFISLPSYRRHMIMH | ||||||
Zinc finger | 364-386 | C2H2-type 10 | ||||
Sequence: YKCKECGKAFDCPSSFQIHERTH | ||||||
Zinc finger | 392-414 | C2H2-type 11 | ||||
Sequence: YECKQCGKAFSCSSSFRMHERTH | ||||||
Zinc finger | 420-442 | C2H2-type 12 | ||||
Sequence: HECKQCGKAFSCSSSVRIHERTH | ||||||
Zinc finger | 448-470 | C2H2-type 13 | ||||
Sequence: YECKQCGKAFSCSSSFRMHERIH | ||||||
Zinc finger | 476-498 | C2H2-type 14 | ||||
Sequence: YECKQCGKAFSFSSSFRMHERTH | ||||||
Zinc finger | 504-526 | C2H2-type 15 | ||||
Sequence: YECKQCGKAFSCSSSFRMHERTH | ||||||
Zinc finger | 532-554 | C2H2-type 16 | ||||
Sequence: YECKQCGKAFSCSSSIRIHERTH | ||||||
Zinc finger | 560-582 | C2H2-type 17 | ||||
Sequence: YECKQCGKAFSCSSSVRMHERTH | ||||||
Zinc finger | 588-610 | C2H2-type 18 | ||||
Sequence: YECKQCDKAFSCSRSFRIHERTH | ||||||
Zinc finger | 616-638 | C2H2-type 19 | ||||
Sequence: YACQQCGKAFKCSRSFRIHERVH |
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length641
- Mass (Da)74,652
- Last updated2002-10-01 v1
- Checksum51BDA6D9D6DE0B41
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H7C129 | H7C129_HUMAN | ZNF709 | 133 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK095600 EMBL· GenBank· DDBJ | BAC04584.1 EMBL· GenBank· DDBJ | mRNA | ||
AK290911 EMBL· GenBank· DDBJ | BAF83600.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471106 EMBL· GenBank· DDBJ | EAW84275.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC136746 EMBL· GenBank· DDBJ | AAI36747.1 EMBL· GenBank· DDBJ | mRNA | ||
BC136751 EMBL· GenBank· DDBJ | AAI36752.1 EMBL· GenBank· DDBJ | mRNA |