Q8N7M2 · ZN283_HUMAN
- ProteinZinc finger protein 283
- GeneZNF283
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids679 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May be involved in transcriptional regulation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Community annotation
The subsequence EESHGALISSCNSRTMTDGLVTFRDVAIDFSQEEWECLDPAQRDLYVDVMLENYSNLVSLDLESKTYETKKIFSENDIFE, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.
Source | Submission date | Contributor |
---|---|---|
PubMed:33326746 | ![]() |
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein 283
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8N7M2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | VAR_060605 | 314 | in dbSNP:rs2195980 | ||
Natural variant | VAR_057416 | 629 | in dbSNP:rs1061768 | ||
Natural variant | VAR_060606 | 638 | in dbSNP:rs2356437 | ||
Natural variant | VAR_060607 | 638 | in dbSNP:rs1061769 | ||
Natural variant | VAR_057417 | 646 | in dbSNP:rs10417624 | ||
Variants
![](/variants.8e7f84.jpg)
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 851 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), cross-link.
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Chain | PRO_0000047507 | 1-679 | UniProt | Zinc finger protein 283 | ||
Modified residue (large scale data) | 145 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 168 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 192 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 221 | PTMeXchange | Sumoylated lysine | |||
Cross-link | 280 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | |||
Modified residue (large scale data) | 280 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 289 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 298 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 345 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 354 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 378 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 429 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 438 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 457 | PTMeXchange | Sumoylated lysine | |||
Cross-link | 476 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | |||
Modified residue (large scale data) | 476 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 541 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 550 | PTMeXchange | Sumoylated lysine | |||
Cross-link | 588 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | |||
Modified residue (large scale data) | 588 | PTMeXchange | Sumoylated lysine | |||
Modified residue (large scale data) | 625 | PTMeXchange | Sumoylated lysine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Detected in prostate, testis, and pancreas.
Gene expression databases
Organism-specific databases
Structure
Family & Domains
Features
Showing features for domain, zinc finger.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 73-152 | KRAB | |||
Zinc finger | 205-227 | C2H2-type 1 | |||
Zinc finger | 233-255 | C2H2-type 2 | |||
Zinc finger | 261-283 | C2H2-type 3 | |||
Zinc finger | 289-311 | C2H2-type 4 | |||
Zinc finger | 317-339 | C2H2-type 5 | |||
Zinc finger | 345-367 | C2H2-type 6 | |||
Zinc finger | 373-395 | C2H2-type 7 | |||
Zinc finger | 401-423 | C2H2-type 8 | |||
Zinc finger | 429-451 | C2H2-type 9 | |||
Zinc finger | 457-479 | C2H2-type 10 | |||
Zinc finger | 485-507 | C2H2-type 11 | |||
Zinc finger | 513-535 | C2H2-type 12 | |||
Zinc finger | 541-563 | C2H2-type 13 | |||
Zinc finger | 569-591 | C2H2-type 14 | |||
Zinc finger | 597-619 | C2H2-type 15 | |||
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length679
- Mass (Da)77,942
- Last updated2009-11-24 v4
- MD5 Checksum2063BD88040DC1AAADDBADE7FBBA7F03
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q4G0N1 | Q4G0N1_HUMAN | ZNF283 | 83 | ||
A0A494C0U8 | A0A494C0U8_HUMAN | ZNF283 | 643 | ||
K7EL69 | K7EL69_HUMAN | ZNF283 | 45 | ||
K7ESH0 | K7ESH0_HUMAN | ZNF283 | 54 |
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 139-140 | in Ref. 1; BAG57956 | |||
Sequence conflict | 172 | in Ref. 4; AAS55109 | |||
Sequence conflict | 432 | in Ref. 4; AAS55109 | |||
Sequence conflict | 638 | in Ref. 1; BAC05251/BAG57956 and 4; AAS55109 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK098175 EMBL· GenBank· DDBJ | BAC05251.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AK294852 EMBL· GenBank· DDBJ | BAG57956.1 EMBL· GenBank· DDBJ | mRNA | ||
AC011508 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AY166784 EMBL· GenBank· DDBJ | AAO45833.1 EMBL· GenBank· DDBJ | mRNA | ||
AY500359 EMBL· GenBank· DDBJ | AAS55109.1 EMBL· GenBank· DDBJ | mRNA |