Q8N7J2 · AMER2_HUMAN
- ProteinAPC membrane recruitment protein 2
- GeneAMER2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids671 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | beta-catenin binding | |
Molecular Function | phosphatidylinositol-4,5-bisphosphate binding | |
Biological Process | ectoderm development | |
Biological Process | negative regulation of canonical Wnt signaling pathway | |
Biological Process | regulation of canonical Wnt signaling pathway | |
Biological Process | Wnt signaling pathway |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAPC membrane recruitment protein 2
- Short namesAmer2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8N7J2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Note: Translocates to the cell membrane following binding to PtdIns(4,5)P2.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | VAR_036448 | 457 | in a colorectal cancer sample; somatic mutation | ||
Natural variant | VAR_031303 | 659 | in dbSNP:rs2282406 | ||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 907 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Chain | PRO_0000281885 | 1-671 | UniProt | APC membrane recruitment protein 2 | ||
Modified residue | 162 | UniProt | Phosphoserine | |||
Modified residue | 229 | UniProt | Phosphoserine | |||
Modified residue | 233 | UniProt | Phosphoserine | |||
Modified residue (large scale data) | 233 | PRIDE | Phosphoserine | |||
Modified residue | 355 | UniProt | Phosphoserine | |||
Modified residue | 358 | UniProt | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-24 | Disordered | |||
Region | 76-358 | Disordered | |||
Compositional bias | 153-169 | Polar residues | |||
Compositional bias | 172-189 | Basic and acidic residues | |||
Compositional bias | 200-215 | Basic and acidic residues | |||
Compositional bias | 239-256 | Basic and acidic residues | |||
Compositional bias | 296-314 | Basic and acidic residues | |||
Region | 391-414 | Disordered | |||
Region | 444-598 | Disordered | |||
Compositional bias | 470-517 | Basic and acidic residues | |||
Compositional bias | 520-536 | Polar residues | |||
Compositional bias | 572-587 | Polar residues | |||
Sequence similarities
Belongs to the Amer family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8N7J2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length671
- Mass (Da)69,507
- Last updated2011-06-28 v3
- MD5 Checksum247E5F9BAE6E6398108841A926432208
Q8N7J2-2
- Name2
- Differences from canonical
- 261-379: Missing
Sequence caution
Features
Showing features for sequence conflict, compositional bias, alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 120 | in Ref. 1; BAB70845 | |||
Sequence conflict | 142 | in Ref. 3; AAH41392 | |||
Compositional bias | 153-169 | Polar residues | |||
Compositional bias | 172-189 | Basic and acidic residues | |||
Compositional bias | 200-215 | Basic and acidic residues | |||
Compositional bias | 239-256 | Basic and acidic residues | |||
Alternative sequence | VSP_024089 | 261-379 | in isoform 2 | ||
Sequence conflict | 265 | in Ref. 1; BAC05288 | |||
Sequence conflict | 290 | in Ref. 3; AAH41392 | |||
Compositional bias | 296-314 | Basic and acidic residues | |||
Sequence conflict | 442 | in Ref. 1; BAB70845 | |||
Compositional bias | 470-517 | Basic and acidic residues | |||
Sequence conflict | 511 | in Ref. 3; AAH41392 | |||
Compositional bias | 520-536 | Polar residues | |||
Compositional bias | 572-587 | Polar residues | |||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK055049 EMBL· GenBank· DDBJ | BAB70845.1 EMBL· GenBank· DDBJ | mRNA | ||
AK098343 EMBL· GenBank· DDBJ | BAC05288.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AL359757 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC032653 EMBL· GenBank· DDBJ | AAH32653.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC041392 EMBL· GenBank· DDBJ | AAH41392.1 EMBL· GenBank· DDBJ | mRNA | Frameshift |