Identification of Murr1 as a regulator of the human delta epithelial sodium channel.Biasio W., Chang T., McIntosh C.J., McDonald F.J.View abstractCited forFUNCTION, INTERACTION WITH SCNN1DCategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 279:5429-5434 (2004)Cited in1Mapped to12
COMMD proteins, a novel family of structural and functional homologs of MURR1.Burstein E., Hoberg J.E., Wilkinson A.S., Rumble J.M., Csomos R.A., Komarck C.M., Maine G.N., Wilkinson J.C., Mayo M.W., Duckett C.S.View abstractCited forFUNCTION, INTERACTION WITH RELA; REL; RELB; NFKB1; NFKB2; COMMD2; COMMD3; COMMD4; COMMD5; COMMD6; COMMD7; COMMD8 AND COMMD10, SUBCELLULAR LOCATION, TISSUE SPECIFICITYCategoriesFunction, Expression, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 280:22222-22232 (2005)Cited in11Mapped to99+
Characterization and copper binding properties of human COMMD1 (MURR1).Narindrasorasak S., Kulkarni P., Deschamps P., She Y.M., Sarkar B.View abstractCited forFUNCTION, SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY, MUTAGENESIS OF MET-110 AND HIS-134, COPPER-BINDINGCategoriesFunction, Sequences, Disease & Variants, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochemistry 46:3116-3128 (2007)Cited in1Mapped to5
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin- containing ubiquitin ligase.Maine G.N., Mao X., Komarck C.M., Burstein E.View abstractCited forFUNCTION, SUBUNIT, INTERACTION WITH SOCS1 AND CUL2, IDENTIFICATION IN AN E3 UBIQUITIN LIGASE COMPLEX COMPOSED OF TCEB1/ELONGIN C; CUL2; SOCS1 AND RBX1CategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCEMBO J. 26:436-447 (2007)Cited in1Mapped to99+
COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate.Burkhead J.L., Morgan C.T., Shinde U., Haddock G., Lutsenko S.View abstractCited forFUNCTION, SUBCELLULAR LOCATIONCategoriesFunction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 284:696-707 (2009)Cited in1Mapped to5
COMMD1 downregulates the epithelial sodium channel through Nedd4-2.Ke Y., Butt A.G., Swart M., Liu Y.F., McDonald F.J.View abstractCited forFUNCTION, INTERACTION WITH SGK1 AND AKT1CategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCAm. J. Physiol. 298:F1445-F1456 (2010)Cited in1Mapped to10
Nucleolar targeting of RelA(p65) is regulated by COMMD1-dependent ubiquitination.Thoms H.C., Loveridge C.J., Simpson J., Clipson A., Reinhardt K., Dunlop M.G., Stark L.A.View abstractCited forFUNCTIONCategoriesFunctionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCancer Res. 70:139-149 (2010)Cited in1Mapped to14
Cu,Zn superoxide dismutase maturation and activity are regulated by COMMD1.Vonk W.I., Wijmenga C., Berger R., van de Sluis B., Klomp L.W.View abstractCited forFUNCTION, INTERACTION WITH CCSCategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 285:28991-29000 (2010)Cited in2Mapped to22
COMMD1 disrupts HIF-1alpha/beta dimerization and inhibits human tumor cell invasion.van de Sluis B., Mao X., Zhai Y., Groot A.J., Vermeulen J.F., van der Wall E., van Diest P.J., Hofker M.H., Wijmenga C.[...], Burstein E.View abstractCited forFUNCTION, INTERACTION WITH HIF1A, TISSUE SPECIFICITYCategoriesFunction, Expression, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Clin. Invest. 120:2119-2130 (2010)Cited in1
COMMD1 regulates the delta epithelial sodium channel (deltaENaC) through trafficking and ubiquitination.Chang T., Ke Y., Ly K., McDonald F.J.View abstractCited forFUNCTION, SUBCELLULAR LOCATIONCategoriesFunction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCBiochem. Biophys. Res. Commun. 411:506-511 (2011)Cited in1Mapped to10
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8- dissociated protein 1) binding.Mao X., Gluck N., Chen B., Starokadomskyy P., Li H., Maine G.N., Burstein E.View abstractCited forFUNCTION, INTERACTION WITH CUL1; CUL2; CUL3; CUL4A; CUL4B; CUL5 AND CUL7, SUBCELLULAR LOCATIONCategoriesFunction, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Biol. Chem. 286:32355-32365 (2011)Cited in11Mapped to99+
COMMD1-mediated ubiquitination regulates CFTR trafficking.Drevillon L., Tanguy G., Hinzpeter A., Arous N., de Becdelievre A., Aissat A., Tarze A., Goossens M., Fanen P.View abstractCited forFUNCTION, INTERACTION WITH CFTR, SUBCELLULAR LOCATIONCategoriesFunction, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS ONE 6:E18334-E18334 (2011)Cited in1Mapped to71
COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination.Smith L., Litman P., Liedtke C.M.View abstractCited forFUNCTION, INTERACTION WITH SLC12A2CategoriesFunction, InteractionSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCAm. J. Physiol. 305:C133-C146 (2013)Cited in1Mapped to10
COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.Phillips-Krawczak C.A., Singla A., Starokadomskyy P., Deng Z., Osborne D.G., Li H., Dick C.J., Gomez T.S., Koenecke M.[...], Burstein E.View abstractCited forFUNCTION, IDENTIFICATION IN THE CCC COMPLEX, SUBCELLULAR LOCATION, SUBUNITCategoriesFunction, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCMol. Biol. Cell 26:91-103 (2015)Cited in15Mapped to99+
A novel nuclear complex of DRR1, F-actin and COMMD1 involved in NF-kappaB degradation and cell growth suppression in neuroblastoma.Mu P., Akashi T., Lu F., Kishida S., Kadomatsu K.View abstractCited forFUNCTION, INTERACTION WITH FAM107A, SUBCELLULAR LOCATIONCategoriesFunction, Interaction, Subcellular LocationSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCOncogene 36:5745-5756 (2017)Cited in3Mapped to14
Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein.Lee S., Neumann M., Stearman R., Stauber R., Pause A., Pavlakis G.N., Klausner R.D.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-8955110PubMedEurope PMCMol Cell Biol 19:1486-1497 (1999)Mapped to36
UBXN7 cofactor of CRL3pisup>KEAP1pi/sup> and CRL2pisup>VHLpi/sup> ubiquitin ligase complexes mediates reciprocal regulation of NRF2 and HIF- 1alpha proteins.Di Gregorio J., Cilenti L., Ambivero C.T., Andl T., Liao R., Zervos A.S.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-8955110PubMedEurope PMCBiochim Biophys Acta Mol Cell Res 1868:118963-118963 (2021)Mapped to94
Long non-coding RNA SNHG5 suppresses the development of acute respiratory distress syndrome by targeting miR-205/COMMD1 axis.Wang J., Zhang Y., Zhang L.View abstractAnnotationLong non-coding RNA SNHG5 suppresses the development of acute respiratory distress syndrome by targeting miR-205/COMMD1 axis.CategoriesFunction, ExpressionSourceGeneRif: 150684PubMedEurope PMCMol Cell Biochem 476:1063-1074 (2021)Mapped to6
Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1alpha) and metabolic reprogramming by modulating the UBXN7 cofactor protein.Cilenti L., Di Gregorio J., Ambivero C.T., Andl T., Liao R., Zervos A.S.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-8955110PubMedEurope PMCSci Rep 10:1609-1609 (2020)Mapped to83
COMMD1 regulates cell proliferation and cell cycle progression by modulating p21 Cip1 levels.Jiang Z., Yuan Y., Zheng H., Cui H., Sun X., Zhao W., Liu X.View abstractAnnotationresults suggest that COMMD1 regulates cell proliferation and cell cycle progression by modulating p21 Cip1 levelsCategoriesFunction, ExpressionSourceGeneRif: 150684PubMedEurope PMCBiosci Biotechnol Biochem 83:845-850 (2019)Mapped to9
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases.Cuadrado A., Rojo A.I., Wells G., Hayes J.D., Cousin S.P., Rumsey W.L., Attucks O.C., Franklin S., Levonen A.L.[...], Dinkova-Kostova A.T.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-8955110PubMedEurope PMCNat Rev Drug Discov 18:295-317 (2019)Mapped to43
Transcriptional regulation of HIV-1 host factor COMMD1 by the Sp family.Kudo E., Taura M., Suico M.A., Goto H., Kai H., Okada S.View abstractAnnotationSp1 constitutively regulates the basal expression of the COMMD1 gene in human epithelial cell lines.CategoriesFunction, Sequences, ExpressionSourceGeneRif: 150684PubMedEurope PMCInt J Mol Med 41:2366-2374 (2018)Mapped to12
Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis.Murata K., Fang C., Terao C., Giannopoulou E.G., Lee Y.J., Lee M.J., Mun S.H., Bae S., Qiao Y.[...], Ivashkiv L.B.View abstractAnnotationthese results identify COMMD1 and an E2F-metabolic pathway as key regulators of osteoclastogenic responses under pathological inflammatory conditionsCategoriesFunctionSourceGeneRif: 150684PubMedEurope PMCImmunity 47:66-79.e5 (2017)Mapped to14
Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation.Scott D.C., Rhee D.Y., Duda D.M., Kelsall I.R., Olszewski J.L., Paulo J.A., de Jong A., Ovaa H., Alpi A.F.[...], Schulman B.A.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-8955110PubMedEurope PMCCell 166:1198-1214 (2016)Cited in9Mapped to64
The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions.Cai W., Yang H.View abstractAnnotationPathwayCategoriesFunctionSourceReactome: R-HSA-8955110PubMedEurope PMCCell Div 11:7-7 (2016)Mapped to31