increased ventricular DPP10 expression in heart failure might promote arrhythmias by decreasing peak Na(+) current while increasing window Na(+) current and channel re-openings due to accelerated recovery from inactivation
The stoichiometry of the Kv4.2-DPP10 complex was variable depending on the relative expression level of each subunit with a preference for 4:2 stoichiometry
the interaction of DPP10a expressed in human atrium with Kv4.3 channels generates a sustained current component of Ito which may affect late repolarization phase of atrial action potentials.
study suggests a genetic contribution of DPP10 rs17048175 in eosinophilic inflammation induction in the airways and to aspirin-exacerbated respiratory disease susceptibility
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