Q8N3C0 · ASCC3_HUMAN
- ProteinActivating signal cointegrator 1 complex subunit 3
- GeneASCC3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids2202 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
3'-5' DNA helicase involved in repair of alkylated DNA: promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions (PubMed:22055184).
Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773).
Drives the splitting of stalled ribosomes that are ubiquitinated in a ZNF598-dependent manner, as part of the ribosome quality control trigger (RQT) complex (PubMed:28757607, PubMed:32099016, PubMed:32579943, PubMed:36302773).
Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | activating signal cointegrator 1 complex | |
Cellular Component | cytosol | |
Cellular Component | cytosolic ribosome | |
Cellular Component | DNA repair complex | |
Cellular Component | membrane | |
Cellular Component | nuclear speck | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | 3'-5' DNA helicase activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | RNA binding | |
Biological Process | DNA alkylation repair | |
Biological Process | DNA duplex unwinding | |
Biological Process | rescue of stalled ribosome | |
Biological Process | ribosome disassembly | |
Biological Process | ribosome-associated ubiquitin-dependent protein catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameActivating signal cointegrator 1 complex subunit 3
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8N3C0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Intellectual developmental disorder, autosomal recessive 81 (MRT81)
- Note
- DescriptionAn autosomal recessive disorder characterized by variable features including mild to severe developmental delay, hypotonia, feeding difficulties, extreme fatigue, and neurobehavioral abnormalities.
- See alsoMIM:620700
Natural variants in MRT81
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_089330 | 1211-2202 | missing | in MRT81; uncertain significance; dbSNP:rs372947820 | |
VAR_089331 | 1427 | T>M | in MRT81; uncertain significance; dbSNP:rs1483972453 | |
VAR_089332 | 1472 | R>Q | in MRT81; uncertain significance; dbSNP:rs1051651433 | |
VAR_089333 | 1518 | R>H | in MRT81; uncertain significance; dbSNP:rs148742449 | |
VAR_089334 | 1564 | S>P | in MRT81; uncertain significance; dbSNP:rs1414695401 | |
VAR_089335 | 1652 | G>D | in MRT81; uncertain significance; dbSNP:rs749948570 | |
VAR_089336 | 1662 | I>F | in MRT81; uncertain significance | |
VAR_089337 | 1761-2202 | missing | in MRT81; uncertain significance; dbSNP:rs1045124261 | |
VAR_089338 | 1898 | H>R | in MRT81; uncertain significance; dbSNP:rs1381176199 |
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_034859 | 146 | in dbSNP:rs9390698 | |||
Sequence: L → F | ||||||
Natural variant | VAR_049339 | 344 | in dbSNP:rs6918004 | |||
Sequence: E → K | ||||||
Natural variant | VAR_049340 | 478 | in dbSNP:rs7750940 | |||
Sequence: N → S | ||||||
Mutagenesis | 505 | Defective activation of the ribosome quality control (RQC) pathway. Impairs its association with ribosomes. | ||||
Sequence: K → R | ||||||
Natural variant | VAR_061212 | 1016 | in dbSNP:rs57534235 | |||
Sequence: S → C | ||||||
Natural variant | VAR_034860 | 1050 | in dbSNP:rs9497983 | |||
Sequence: V → I | ||||||
Natural variant | VAR_089330 | 1211-2202 | in MRT81; uncertain significance; dbSNP:rs372947820 | |||
Sequence: Missing | ||||||
Mutagenesis | 1354 | Abolishes 3'-5' DNA helicase activity and ability to promote DNA repair. | ||||
Sequence: G → D | ||||||
Natural variant | VAR_049341 | 1425 | in dbSNP:rs17246013 | |||
Sequence: V → A | ||||||
Natural variant | VAR_089331 | 1427 | in MRT81; uncertain significance; dbSNP:rs1483972453 | |||
Sequence: T → M | ||||||
Natural variant | VAR_089332 | 1472 | in MRT81; uncertain significance; dbSNP:rs1051651433 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_049342 | 1497 | in dbSNP:rs17305382 | |||
Sequence: R → T | ||||||
Natural variant | VAR_089333 | 1518 | in MRT81; uncertain significance; dbSNP:rs148742449 | |||
Sequence: R → H | ||||||
Natural variant | VAR_089334 | 1564 | in MRT81; uncertain significance; dbSNP:rs1414695401 | |||
Sequence: S → P | ||||||
Natural variant | VAR_089335 | 1652 | in MRT81; uncertain significance; dbSNP:rs749948570 | |||
Sequence: G → D | ||||||
Natural variant | VAR_089336 | 1662 | in MRT81; uncertain significance | |||
Sequence: I → F | ||||||
Natural variant | VAR_089337 | 1761-2202 | in MRT81; uncertain significance; dbSNP:rs1045124261 | |||
Sequence: Missing | ||||||
Natural variant | VAR_034861 | 1800 | in dbSNP:rs35011147 | |||
Sequence: C → W | ||||||
Natural variant | VAR_089338 | 1898 | in MRT81; uncertain significance; dbSNP:rs1381176199 | |||
Sequence: H → R | ||||||
Natural variant | VAR_034862 | 1930 | in dbSNP:rs3213542 | |||
Sequence: V → M | ||||||
Natural variant | VAR_034863 | 1995 | in dbSNP:rs240780 | |||
Sequence: S → C | ||||||
Natural variant | VAR_034864 | 2176 | in dbSNP:rs240768 | |||
Sequence: Y → C |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2,175 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000102093 | 1-2202 | UniProt | Activating signal cointegrator 1 complex subunit 3 | |||
Sequence: MALPRLTGALRSFSNVTKQDNYNEEVADLKIKRSKLHEQVLDLGLTWKKIIKFLNEKLEKSKMQSINEDLKDILHAAKQIVGTDNGREAIESGAAFLFMTFHLKDSVGHKETKAIKQMFGPFPSSSATAACNATNRIISHFSQDDLTALVQMTEKEHGDRVFFGKNLAFSFDMHDLDHFDELPINGETQKTISLDYKKFLNEHLQEACTPELKPVEKTNGSFLWCEVEKYLNSTLKEMTEVPRVEDLCCTLYDMLASIKSGDELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSNDHRFQALQDNCKKILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKRIARREKKAGEDLEVSEGLMCFDPKELRIQREQALLNARSVPILSRQRDADVEKIHYPHVYDSQAEAMKTSAFIAGAKMILPEGIQRENNKLYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQFLESLADNLNAEIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEERTGYFSSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTLSIYADFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKEAQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLYFMSDCYLGLDQQYDIYLNVTQASLSAQVNTKVSDSLTDLALK | |||||||
Modified residue | 12 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 139 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 142 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 209 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 221 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 298 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 452 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 572 | UniProt | N6-acetyllysine | ||||
Sequence: K | |||||||
Modified residue (large scale data) | 2193 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 2195 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 2195 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Subunit
Functions as scaffolding subunit that interacts directly with both ASCC1 and ASCC2 (PubMed:29144457, PubMed:29997253).
Interacts directly with ALKBH3, and thereby recruits ALKBH3 to the ASCC complex (PubMed:22055184, PubMed:29144457).
Part of the ASC-1/TRIP4 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347).
Part of the RQT (ribosome quality control trigger) complex, that contains ASCC2, ASCC3 and TRIP4 (PubMed:32099016, PubMed:32579943, PubMed:36302773).
Associates with ribosomes; recruited to collided ribosomes (PubMed:32099016, PubMed:32579943, PubMed:36302773).
Interacts with ZCCHC4 (PubMed:31799605).
Interacts with ZNF598 (PubMed:28757607).
Interacts with RPS3 (PubMed:28757607).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8N3C0 | ASCC1 Q8N9N2 | 3 | EBI-1210710, EBI-10268317 | |
BINARY | Q8N3C0 | ASCC1 Q8N9N2-2 | 4 | EBI-1210710, EBI-10962548 | |
BINARY | Q8N3C0 | ASCC2 Q9H1I8 | 9 | EBI-1210710, EBI-711197 | |
BINARY | Q8N3C0 | HCCS P53701 | 2 | EBI-1210710, EBI-10763431 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, coiled coil, domain, motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-400 | Required for interaction with ASCC2 | ||||
Sequence: MALPRLTGALRSFSNVTKQDNYNEEVADLKIKRSKLHEQVLDLGLTWKKIIKFLNEKLEKSKMQSINEDLKDILHAAKQIVGTDNGREAIESGAAFLFMTFHLKDSVGHKETKAIKQMFGPFPSSSATAACNATNRIISHFSQDDLTALVQMTEKEHGDRVFFGKNLAFSFDMHDLDHFDELPINGETQKTISLDYKKFLNEHLQEACTPELKPVEKTNGSFLWCEVEKYLNSTLKEMTEVPRVEDLCCTLYDMLASIKSGDELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSNDHRFQALQDNCKKILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKRIARREKKAGEDLEVSEGLMCFDPKELRIQREQALLNARSVPILSRQRDADVEKI | ||||||
Coiled coil | 18-79 | |||||
Sequence: KQDNYNEEVADLKIKRSKLHEQVLDLGLTWKKIIKFLNEKLEKSKMQSINEDLKDILHAAKQ | ||||||
Coiled coil | 328-356 | |||||
Sequence: IQSEQEKQLMKQYRREEKRIARREKKAGE | ||||||
Domain | 486-669 | Helicase ATP-binding 1 | ||||
Sequence: ETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGL | ||||||
Motif | 611-614 | DEVH box | ||||
Sequence: DEVH | ||||||
Domain | 728-914 | Helicase C-terminal 1 | ||||
Sequence: TVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQFLESLADNLNAEIALGTVTNVEEAV | ||||||
Domain | 978-1287 | SEC63 1 | ||||
Sequence: STDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTLSIYADFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKEAQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINF | ||||||
Domain | 1336-1511 | Helicase ATP-binding 2 | ||||
Sequence: HTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLF | ||||||
Motif | 1453-1456 | DEIH box | ||||
Sequence: DEIH | ||||||
Domain | 1544-1739 | Helicase C-terminal 2 | ||||
Sequence: PAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEI | ||||||
Domain | 1812-2176 | SEC63 2 | ||||
Sequence: PLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLYFMSDCYLGLDQQYDIY |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q8N3C0-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length2,202
- Mass (Da)251,460
- Last updated2007-09-11 v3
- Checksum9F074E6E5853399C
Q8N3C0-3
- Name2
Q8N3C0-4
- Name3
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_042955 | 81-111 | in isoform 2 | |||
Sequence: VGTDNGREAIESGAAFLFMTFHLKDSVGHKE → EVNCPFQKRRLDGKEEDEKMSRASDRFRGLR | ||||||
Sequence conflict | 86 | in Ref. 5; AAH26066 | ||||
Sequence: G → E | ||||||
Alternative sequence | VSP_042956 | 112-2202 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 444 | in Ref. 1; CAD39122 | ||||
Sequence: P → S | ||||||
Sequence conflict | 582 | in Ref. 5; AAH26066 | ||||
Sequence: V → A | ||||||
Alternative sequence | VSP_042957 | 719-731 | in isoform 3 | |||
Sequence: MVFVHARNATVRT → HLFYLLLHLFICF | ||||||
Alternative sequence | VSP_042958 | 732-2202 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 750 | in Ref. 1; CAD39122 | ||||
Sequence: P → S | ||||||
Sequence conflict | 1187 | in Ref. 7; CAA11679 | ||||
Sequence: S → F | ||||||
Sequence conflict | 1343 | in Ref. 7; CAA11679 | ||||
Sequence: C → S |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL834463 EMBL· GenBank· DDBJ | CAD39122.1 EMBL· GenBank· DDBJ | mRNA | ||
AK315197 EMBL· GenBank· DDBJ | BAG37637.1 EMBL· GenBank· DDBJ | mRNA | ||
AL121965 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL133338 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL356122 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL591585 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
Z86062 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471051 EMBL· GenBank· DDBJ | EAW48449.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC050681 EMBL· GenBank· DDBJ | AAH50681.1 EMBL· GenBank· DDBJ | mRNA | ||
BC125211 EMBL· GenBank· DDBJ | AAI25212.1 EMBL· GenBank· DDBJ | mRNA | ||
BC125212 EMBL· GenBank· DDBJ | AAI25213.1 EMBL· GenBank· DDBJ | mRNA | ||
BC026066 EMBL· GenBank· DDBJ | AAH26066.1 EMBL· GenBank· DDBJ | mRNA | ||
AY013288 EMBL· GenBank· DDBJ | AAG45474.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AJ223948 EMBL· GenBank· DDBJ | CAA11679.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. |