Q8N2K1 · UB2J2_HUMAN
- ProteinUbiquitin-conjugating enzyme E2 J2
- GeneUBE2J2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids259 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity).
In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2 (PubMed:36528027).
In cooperation with the GATOR2 complex, catalyzes 'Lys-6'-linked ubiquitination of NPRL2 (PubMed:36528027).
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 94 | Glycyl thioester intermediate | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | nucleus | |
Cellular Component | ubiquitin ligase complex | |
Molecular Function | ATP binding | |
Molecular Function | ubiquitin conjugating enzyme activity | |
Molecular Function | ubiquitin protein ligase binding | |
Biological Process | ERAD pathway | |
Biological Process | positive regulation of protein targeting to mitochondrion | |
Biological Process | protein K6-linked ubiquitination | |
Biological Process | protein polyubiquitination | |
Biological Process | response to unfolded protein | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquitin-conjugating enzyme E2 J2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8N2K1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type IV membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-226 | Cytoplasmic | ||||
Sequence: MSSTSSKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEWHYVVRGPEMTPYEGGYYHGKLIFPREFPFKPPSIYMITPNGRFKCNTRLCLSITDFHPDTWNPAWSVSTILTGLLSFMVEKGPTLGSIETSDFTKRQLAVQSLAFNLKDKVFCELFPEVVEEIKQKQKAQDELSSRPQTLPLPDVVPDGETHLVQNGIQLLNGHAPGAVPNLAGLQQANRHH | ||||||
Transmembrane | 227-247 | Helical; Anchor for type IV membrane protein | ||||
Sequence: GLLGGALANLFVIVGFAAFAY | ||||||
Topological domain | 248-259 | Lumenal | ||||
Sequence: TVKYVLRSIAQE |
Keywords
- Cellular component
Disease & Variants
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000082596 | 1-259 | Ubiquitin-conjugating enzyme E2 J2 | |||
Sequence: MSSTSSKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEWHYVVRGPEMTPYEGGYYHGKLIFPREFPFKPPSIYMITPNGRFKCNTRLCLSITDFHPDTWNPAWSVSTILTGLLSFMVEKGPTLGSIETSDFTKRQLAVQSLAFNLKDKVFCELFPEVVEEIKQKQKAQDELSSRPQTLPLPDVVPDGETHLVQNGIQLLNGHAPGAVPNLAGLQQANRHHGLLGGALANLFVIVGFAAFAYTVKYVLRSIAQE |
Post-translational modification
Auto-ubiquitinated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8N2K1 | AQP6 Q13520 | 3 | EBI-2340110, EBI-13059134 | |
BINARY | Q8N2K1 | ELOVL7 A1L3X0 | 3 | EBI-2340110, EBI-10285373 | |
BINARY | Q8N2K1 | GNB2 P62879 | 3 | EBI-2340110, EBI-356942 | |
BINARY | Q8N2K1 | RBP1 P09455 | 3 | EBI-2340110, EBI-2623483 | |
BINARY | Q8N2K1 | TMEM14B Q9NUH8 | 3 | EBI-2340110, EBI-8638294 | |
BINARY | Q8N2K1 | TRIM59 Q8IWR1 | 3 | EBI-2340110, EBI-10262539 | |
BINARY | Q8N2K1 | WFS1 O76024 | 3 | EBI-2340110, EBI-720609 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-162 | UBC core | ||||
Sequence: TATQRLKQDYLRIKKDPVPYICAEPLPSNILEWHYVVRGPEMTPYEGGYYHGKLIFPREFPFKPPSIYMITPNGRFKCNTRLCLSITDFHPDTWNPAWSVSTILTGLLSFMVEKGPTLGSIETSDFTKRQLAVQSLAFNLKDKVFCELFPE |
Sequence similarities
Belongs to the ubiquitin-conjugating enzyme family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q8N2K1-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length259
- Mass (Da)28,898
- Last updated2009-07-07 v3
- Checksum7DB5280D2947CE7E
Q8N2K1-2
- Name2
- Differences from canonical
- 1-44: MSSTSSKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEW → MWPQDIAGR
Q8N2K1-3
- Name3
- Differences from canonical
- 44-44: W → WFKRFSWLSLLSSWDYR
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_011572 | 1-44 | in isoform 2 | |||
Sequence: MSSTSSKRAPTTATQRLKQDYLRIKKDPVPYICAEPLPSNILEW → MWPQDIAGR | ||||||
Sequence conflict | 2 | in Ref. 2; BAC11355 | ||||
Sequence: S → N | ||||||
Alternative sequence | VSP_045219 | 44 | in isoform 3 | |||
Sequence: W → WFKRFSWLSLLSSWDYR | ||||||
Sequence conflict | 100 | in Ref. 2; BAC11355 | ||||
Sequence: F → S | ||||||
Sequence conflict | 214-238 | in Ref. 1; AAK52609 | ||||
Sequence: PNLAGLQQANRHHGLLGGALANLFV → QTSQGSSRPTGTTDSGWRPGELVC |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF296658 EMBL· GenBank· DDBJ | AAK52609.1 EMBL· GenBank· DDBJ | mRNA | ||
AK056065 EMBL· GenBank· DDBJ | BAB71086.1 EMBL· GenBank· DDBJ | mRNA | ||
AK075017 EMBL· GenBank· DDBJ | BAC11355.1 EMBL· GenBank· DDBJ | mRNA | ||
AK291935 EMBL· GenBank· DDBJ | BAF84624.1 EMBL· GenBank· DDBJ | mRNA | ||
AL162741 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471183 EMBL· GenBank· DDBJ | EAW56256.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471183 EMBL· GenBank· DDBJ | EAW56259.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC094777 EMBL· GenBank· DDBJ | AAH94777.1 EMBL· GenBank· DDBJ | mRNA | ||
BC104890 EMBL· GenBank· DDBJ | AAI04891.1 EMBL· GenBank· DDBJ | mRNA | ||
BC113430 EMBL· GenBank· DDBJ | AAI13431.1 EMBL· GenBank· DDBJ | mRNA | ||
BC143657 EMBL· GenBank· DDBJ | AAI43658.1 EMBL· GenBank· DDBJ | mRNA | ||
BM544827 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |