Q8N137 · CNTRB_HUMAN
- ProteinCentrobin
- GeneCNTROB
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids903 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | centriole | |
Cellular Component | centrosome | |
Cellular Component | cytoplasm | |
Molecular Function | protein domain specific binding | |
Biological Process | centriole replication | |
Biological Process | centrosome separation | |
Biological Process | mitotic cytokinetic process | |
Biological Process | regulation of cilium assembly |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCentrobin
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8N137
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Centriole-associated, asymmetrically localizes to the daughter centriole.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_050877 | 439 | in dbSNP:rs35421969 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_024787 | 578 | in dbSNP:rs11650083 | |||
Sequence: P → Q |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,089 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000076240 | 1-903 | UniProt | Centrobin | |||
Sequence: MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDLTSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETVPQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSHSQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGGVWR | |||||||
Modified residue (large scale data) | 61 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 62 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 76 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 78 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 80 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 80 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 128 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 135 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 743 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 784 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 787 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 788 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue | 790 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 790 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
Developmental stage
Preferentially incorporated into the newly assembled daughter centriole during centriole assembly at the late G1 or early S phase. Remains in the daughter centrioles throughout the cell cycle. At the next cycle of centriole duplication, its amount on the original daughter centriole eventually decreases.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with LYST.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8N137 | CAD P27708 | 2 | EBI-947360, EBI-355504 | |
BINARY | Q8N137 | COASY Q13057-2 | 3 | EBI-947360, EBI-10227704 | |
BINARY | Q8N137 | CWF19L2 Q2TBE0 | 3 | EBI-947360, EBI-5453285 | |
BINARY | Q8N137 | DUSP29 Q68J44 | 3 | EBI-947360, EBI-1054321 | |
BINARY | Q8N137 | ELOA Q14241 | 3 | EBI-947360, EBI-742350 | |
BINARY | Q8N137 | EPM2AIP1 Q7L775 | 3 | EBI-947360, EBI-6255981 | |
BINARY | Q8N137 | MCRS1 Q96EZ8 | 3 | EBI-947360, EBI-348259 | |
BINARY | Q8N137 | PELI1 Q96FA3 | 3 | EBI-947360, EBI-448369 | |
BINARY | Q8N137 | PNKP Q96T60 | 3 | EBI-947360, EBI-1045072 | |
BINARY | Q8N137 | RAD23A P54725 | 3 | EBI-947360, EBI-746453 | |
BINARY | Q8N137 | RSPH14 Q9UHP6 | 3 | EBI-947360, EBI-748350 | |
BINARY | Q8N137 | SYT6 Q5T7P8-2 | 3 | EBI-947360, EBI-10246152 | |
BINARY | Q8N137 | TCEA2 Q15560 | 3 | EBI-947360, EBI-710310 | |
BINARY | Q8N137 | TSHZ2 Q9NRE2 | 3 | EBI-947360, EBI-10687282 | |
BINARY | Q8N137 | TTC23 Q5W5X9 | 3 | EBI-947360, EBI-6447954 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-34 | Disordered | ||||
Sequence: MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEV | ||||||
Region | 110-140 | Disordered | ||||
Sequence: LQTSRDTAYRDPLIPGAGSERREEDSFDSDS | ||||||
Coiled coil | 196-560 | |||||
Sequence: RRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAH | ||||||
Region | 365-903 | Required for centrosome localization | ||||
Sequence: QEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDLTSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETVPQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSHSQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGGVWR | ||||||
Region | 471-493 | Disordered | ||||
Sequence: LRQAASLREHHRKQLQDLSGQHQ | ||||||
Compositional bias | 474-488 | Basic and acidic residues | ||||
Sequence: AASLREHHRKQLQDL | ||||||
Region | 568-597 | Disordered | ||||
Sequence: LSTTLPPPNPPAPPAGPSSPGPQEPEKEER | ||||||
Compositional bias | 571-588 | Pro residues | ||||
Sequence: TLPPPNPPAPPAGPSSPG | ||||||
Region | 669-704 | Disordered | ||||
Sequence: SALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPA | ||||||
Compositional bias | 675-693 | Basic and acidic residues | ||||
Sequence: HPDHRAERPFPEEDPGPDG | ||||||
Region | 772-799 | Disordered | ||||
Sequence: RVPEPPSSHSQGSGPSSGSPERGGDGLT | ||||||
Compositional bias | 774-789 | Polar residues | ||||
Sequence: PEPPSSHSQGSGPSSG | ||||||
Compositional bias | 837-859 | Basic and acidic residues | ||||
Sequence: SGTDGRGDNVPRRNTDSRLGEIP | ||||||
Region | 837-903 | Disordered | ||||
Sequence: SGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGGVWR |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
Q8N137-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsAlpha
- Length903
- Mass (Da)101,253
- Last updated2002-10-01 v1
- Checksum3F8E6DE4CEF51851
Q8N137-2
- Name2
- SynonymsBeta
- Differences from canonical
- 838-838: G → GYKPGRKEEGFSGWKLDYGEWSG
Q8N137-3
- Name3
- Differences from canonical
- 838-838: G → GR
Q8N137-4
- Name4
Q8N137-5
- Name5
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 474-488 | Basic and acidic residues | ||||
Sequence: AASLREHHRKQLQDL | ||||||
Alternative sequence | VSP_016836 | 526-554 | in isoform 4 | |||
Sequence: AREQARVCELQSGNQQLEEQRVELVERLQ → LLLDPPAPGLRSPRRRRGGSGLCLPWPWP | ||||||
Alternative sequence | VSP_016837 | 555-903 | in isoform 4 | |||
Sequence: Missing | ||||||
Compositional bias | 571-588 | Pro residues | ||||
Sequence: TLPPPNPPAPPAGPSSPG | ||||||
Sequence conflict | 582 | in Ref. 7; AAG49447 | ||||
Sequence: A → D | ||||||
Compositional bias | 675-693 | Basic and acidic residues | ||||
Sequence: HPDHRAERPFPEEDPGPDG | ||||||
Compositional bias | 774-789 | Polar residues | ||||
Sequence: PEPPSSHSQGSGPSSG | ||||||
Compositional bias | 837-859 | Basic and acidic residues | ||||
Sequence: SGTDGRGDNVPRRNTDSRLGEIP | ||||||
Alternative sequence | VSP_016838 | 838 | in isoform 2 | |||
Sequence: G → GYKPGRKEEGFSGWKLDYGEWSG | ||||||
Alternative sequence | VSP_016839 | 838 | in isoform 3 | |||
Sequence: G → GR | ||||||
Alternative sequence | VSP_016840 | 839-864 | in isoform 5 | |||
Sequence: TDGRGDNVPRRNTDSRLGEIPRKEIP → YKPGRKEEGFSGWKLDYGEWSGCVLH | ||||||
Alternative sequence | VSP_016841 | 865-903 | in isoform 5 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY160226 EMBL· GenBank· DDBJ | AAO22135.1 EMBL· GenBank· DDBJ | mRNA | ||
AY160227 EMBL· GenBank· DDBJ | AAO22136.1 EMBL· GenBank· DDBJ | mRNA | ||
AF331638 EMBL· GenBank· DDBJ | AAL56068.2 EMBL· GenBank· DDBJ | mRNA | ||
AL137669 EMBL· GenBank· DDBJ | CAH10698.1 EMBL· GenBank· DDBJ | mRNA | ||
AL833907 EMBL· GenBank· DDBJ | CAD38763.1 EMBL· GenBank· DDBJ | mRNA | ||
AC104581 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC014055 EMBL· GenBank· DDBJ | AAH14055.3 EMBL· GenBank· DDBJ | mRNA | ||
BC021134 EMBL· GenBank· DDBJ | AAH21134.1 EMBL· GenBank· DDBJ | mRNA | ||
AK074847 EMBL· GenBank· DDBJ | BAC11241.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AF141344 EMBL· GenBank· DDBJ | AAG49447.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. |