Q8N103 · TAGAP_HUMAN

  • Protein
    T-cell activation Rho GTPase-activating protein
  • Gene
    TAGAP
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

May function as a GTPase-activating protein and may play important roles during T-cell activation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Molecular FunctionGTPase activator activity
Molecular Functionguanyl-nucleotide exchange factor activity
Biological Processregulation of Rho protein signal transduction
Biological Processregulation of small GTPase mediated signal transduction
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    T-cell activation Rho GTPase-activating protein
  • Alternative names
    • T-cell activation GTPase-activating protein

Gene names

    • Name
      TAGAP
    • Synonyms
      TAGAP1
    • ORF names
      FKSG15

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8N103
  • Secondary accessions
    • Q2NKM8
    • Q8NI40
    • Q96KZ2
    • Q96QA2

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_049146346in dbSNP:rs35263580

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 728 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00000567191-731UniProtT-cell activation Rho GTPase-activating protein
Modified residue (large scale data)68PRIDEPhosphoserine
Modified residue (large scale data)71PRIDEPhosphoserine
Modified residue (large scale data)354PRIDEPhosphoserine
Modified residue (large scale data)377PRIDEPhosphoserine
Modified residue400UniProtPhosphoserine
Modified residue (large scale data)400PRIDEPhosphoserine
Modified residue (large scale data)714PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8N103HSF2BP O750313EBI-12136823, EBI-7116203

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain88-277Rho-GAP
Region288-421Disordered
Compositional bias298-334Polar residues
Compositional bias373-401Polar residues
Compositional bias464-491Polar residues
Region464-507Disordered
Compositional bias492-507Basic and acidic residues
Region641-662Disordered

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q8N103-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    731
  • Mass (Da)
    80,703
  • Last updated
    2002-10-01 v1
  • Checksum
    9D8768258A0A681E
MKLRSSHNASKTLNANNMETLIECQSEGDIKEHPLLASCESEDSICQLIEVKKRKKVLSWPFLMRRLSPASDFSGALETDLKASLFDQPLSIICGDSDTLPRPIQDILTILCLKGPSTEGIFRRAANEKARKELKEELNSGDAVDLERLPVHLLAVVFKDFLRSIPRKLLSSDLFEEWMGALEMQDEEDRIEALKQVADKLPRPNLLLLKHLVYVLHLISKNSEVNRMDSSNLAICIGPNMLTLENDQSLSFEAQKDLNNKVKTLVEFLIDNCFEIFGENIPVHSSITSDDSLEHTDSSDVSTLQNDSAYDSNDPDVESNSSSGISSPSRQPQVPMATAAGLDSAGPQDAREVSPEPIVSTVARLKSSLAQPDRRYSEPSMPSSQECLESRVTNQTLTKSEGDFPVPRVGSRLESEEAEDPFPEEVFPAVQGKTKRPVDLKIKNLAPGSVLPRALVLKAFSSSSLDASSDSSPVASPSSPKRNFFSRHQSFTTKTEKGKPSREIKKHSMSFTFAPHKKVLTKNLSAGSGKSQDFTRDHVPRGVRKESQLAGRIVQENGCETHNQTARGFCLRPHALSVDDVFQGADWERPGSPPSYEEAMQGPAARLVASESQTVGSMTVGSMRARMLEAHCLLPPLPPAHHVEDSRHRGSKEPLPGHGLSPLPERWKQSRTVHASGDSLGHVSGPGRPELLPLRTVSESVQRNKRDCLVRRCSQPVFEADQFQYAKESYI

Q8N103-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8N103-3

  • Name
    3
  • Synonyms
    FKSG15
  • Note
    Dubious isoform. The N-terminus appears to be derived from exons of the CEP43 locus which is located on the opposing strand of chromosome 6 at a distance of several Mb.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-209: Missing
    • 210-261: KHLVYVLHLISKNSEVNRMDSSNLAICIGPNMLTLENDQSLSFEAQKDLNNK → MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVE

Q8N103-4

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAQ5BID7A0AAQ5BID7_HUMANTAGAP67
A0A2R8YEB9A0A2R8YEB9_HUMANTAGAP57

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0158691-178in isoform 2
Alternative sequenceVSP_0158681-209in isoform 3
Alternative sequenceVSP_015870210-261in isoform 3
Alternative sequenceVSP_015871263-266in isoform 4
Alternative sequenceVSP_015872267-731in isoform 4
Compositional bias298-334Polar residues
Compositional bias373-401Polar residues
Compositional bias464-491Polar residues
Compositional bias492-507Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF385429
EMBL· GenBank· DDBJ
AAM43830.1
EMBL· GenBank· DDBJ
mRNA
AF385430
EMBL· GenBank· DDBJ
AAM43831.1
EMBL· GenBank· DDBJ
mRNA
AF314817
EMBL· GenBank· DDBJ
AAL16675.1
EMBL· GenBank· DDBJ
mRNA
AK097090
EMBL· GenBank· DDBJ
BAC04947.1
EMBL· GenBank· DDBJ
mRNA
AL035530
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC015859
EMBL· GenBank· DDBJ
AAH15859.1
EMBL· GenBank· DDBJ
mRNA
BC111731
EMBL· GenBank· DDBJ
AAI11732.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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