Q8MU49 · Q8MU49_DISST

Function

function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN.
heme b (UniProtKB | Rhea| CHEBI:60344 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site153Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Molecular Functioncalmodulin binding
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular FunctionNADP binding
Molecular Functionnitric-oxide synthase activity
Biological Processnitric oxide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nitric oxide synthase
  • EC number

Organism names

Accessions

  • Primary accession
    Q8MU49

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain488-628Flavodoxin-like
Domain684-932FAD-binding FR-type

Sequence similarities

Belongs to the NOS family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,115
  • Mass (Da)
    125,377
  • Last updated
    2002-10-01 v1
  • Checksum
    4D32D67835B02D24
MKEIKVPECPFIGADEKKCPFAAGFQMRSQEPKYLRVNNWIEGTQMVDTLHQKATNPLHCTNGRCTGSIMYPYGGEIPEARPYGIPRPKDEVITHAQDFLEQLYSAKKLSDSQEHLQRRTEVMKAVKETGTYHLTEDELIFASKTAWRNAARCIGRIQWNNLQLFDARHVKTAKEMFEAIKKHLVYATNEGNLRSAITVFPQRKESKKDFRVWNPQLIRYAGYKHLDGTVVGDPASVDFTELCQSLGWKGKGGRFDILPLVLQANGGPPECFELPDELALQVKIKHPKYPWFEKLGLRWYALPAVSNMMLDAGGLEFTAAPFNGWYMVTEIGTRDLADQQRYNMLEPIAKKMGPDTKSNASLWKDFALVELNYAVMYSFQEAGVTLADHHSTSESFMKHMEKEIKLRGGCPADWVWIVPPLSGGATPVFHQEMLNYSLKPSYEYQPDPSNFYSITGKPITKTSFKAVAKATLFSAFLMRKVLSKRKKATVLFATETGRSEGFARNLGKLLSHAFDVKVLCMADYEHVQLKDEKLLFVVASTFGNGDPPENGASFATFLHSMGNAQPLRNLRYSVFGLGSRAYPNFCNFGHYMDDHLKKLGGERILSMGEGDELCGQDESFKEWAKNVFKGACDVFGMKKEASNKVVTLSLENMSTGWGPGLYRWVTDRRKPKDLCSNLSRAYNKTVCPVKVISVKELQSRNSRRSTILVRFDVEKNKELNFEPGDHVAIFPANRANTVQDLIDMMHEKPTPDQPIRIEVARENSGKPGGGRTWESFKRLPVACTLREALTRYLDISSVPTPQMMLYLSKLATSPLEKLQLEALGKGGSRYGDWVLKKECNILETLQAFPSVQVTADLLLTQLPLLQPRFYSISSSPDVHRNEIHATVAVVEYKKRGGQGPVHHGVCSTWLQGLTPGDTAACYIRHAQSFHLPSDATVPVILVGNGTGIAPFRGFWQQRMFDMNNKCLPDPQPGSRQRCGRWGEMALFFGCRNSQHDDVFRHEIEKAIYSKTISTVAKAFSREQGKPKRYVQDLLKEDAGNVCDLIVDSNAHVYVCGGAAMANDVSKTIQNMLADRLSLSADDALEYMRGLKSSNRYHEDVFGVAQRNKEPGGREN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY036119
EMBL· GenBank· DDBJ
AAK61379.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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