Q8MU49 · Q8MU49_DISST
- ProteinNitric oxide synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1115 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions.
Catalytic activity
- 2 L-arginine + 3 NADPH + 4 O2 + H+ = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
2 CHEBI:32682 + 3 CHEBI:57783 + 4 CHEBI:15379 + CHEBI:15378 = 2 CHEBI:57743 + 2 CHEBI:16480 + 3 CHEBI:58349 + 4 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FAD.
Note: Binds 1 FMN.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calmodulin binding | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | FMN binding | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Molecular Function | NADP binding | |
Molecular Function | nitric-oxide synthase activity | |
Biological Process | nitric oxide biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNitric oxide synthase
- EC number
Organism names
- Taxonomic lineageEukaryota > Metazoa > Cnidaria > Anthozoa > Hexacorallia > Corallimorpharia > Discosomidae > Discosoma
Accessions
- Primary accessionQ8MU49
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 488-628 | Flavodoxin-like | ||||
Sequence: ATVLFATETGRSEGFARNLGKLLSHAFDVKVLCMADYEHVQLKDEKLLFVVASTFGNGDPPENGASFATFLHSMGNAQPLRNLRYSVFGLGSRAYPNFCNFGHYMDDHLKKLGGERILSMGEGDELCGQDESFKEWAKNVF | ||||||
Domain | 684-932 | FAD-binding FR-type | ||||
Sequence: KTVCPVKVISVKELQSRNSRRSTILVRFDVEKNKELNFEPGDHVAIFPANRANTVQDLIDMMHEKPTPDQPIRIEVARENSGKPGGGRTWESFKRLPVACTLREALTRYLDISSVPTPQMMLYLSKLATSPLEKLQLEALGKGGSRYGDWVLKKECNILETLQAFPSVQVTADLLLTQLPLLQPRFYSISSSPDVHRNEIHATVAVVEYKKRGGQGPVHHGVCSTWLQGLTPGDTAACYIRHAQSFHLP |
Sequence similarities
Belongs to the NOS family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,115
- Mass (Da)125,377
- Last updated2002-10-01 v1
- Checksum4D32D67835B02D24