Q8MSM8 · Q8MSM8_DROME
- ProteinATP-dependent DNA helicase II subunit 2
- GeneKu80
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids699 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Publications for Q8MSM8
HR repair pathway plays a crucial role in maintaining neural stem cell fate under irradiation stress.
- CategoriesFunction, Phenotypes & Variants
- SourceFlyBase: FBgn0041627
VCP maintains nuclear size by regulating the DNA damage-associated MDC1- p53-autophagy axis in Drosophila.
- CategoriesFunction, Subcellular Location
- SourceFlyBase: FBgn0041627
ERR and dPECR Suggest a Link Between Neuroprotection and the Regulation of Ethanol Consumption Preference.
- CategoriesFunction, Expression
- SourceFlyBase: FBgn0041627
Kinetochore-independent mechanisms of sister chromosome separation.
- CategoryFunction
- SourceFlyBase: FBgn0041627
Evaluation of the geroprotective effects of withaferin A in <i>Drosophila melanogaster</i>.
- CategoryFunction
- SourceFlyBase: FBgn0041627
Identification of novel genes associated with longevity in <i>Drosophila melanogaster</i> - a computational approach.
- CategoriesFunction, Phenotypes & Variants
- SourceFlyBase: FBgn0041627
The role of DNA repair genes in radiation-induced adaptive response in Drosophila melanogaster is differential and conditional.
- CategoriesFunction, Expression
- SourceFlyBase: FBgn0041627
Continuous tracking of startled <i>Drosophila</i> as an alternative to the negative geotaxis climbing assay.
- CategoriesFunction, Phenotypes & Variants
- SourceFlyBase: FBgn0041627
A Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling.
- CategoriesFunction, PTM / Processing
- SourceFlyBase: FBgn0041627
Partial inhibition of the overactivated Ku80-dependent DNA repair pathway rescues neurodegeneration in <i>C9ORF72</i>-ALS/FTD.
- Annotationpartial loss of function of Ku80 in these neurons through CRISPR/Cas9-mediated ablation or small RNAs-mediated knockdown suppressed the apoptotic pathway. Thus partial inhibition of the overactivated Ku80-dependent DNA repair pathway is a promising therapeutic approach in C9ORF72-ALS/FTD.
- CategoriesFunction, Phenotypes & Variants
- SourceFlyBase: FBgn0041627, GeneRif: 34930
<i>Drosophila</i> p53 directs nonapoptotic programs in postmitotic tissue.
- CategoryFunction
- SourceFlyBase: FBgn0041627
Timely double-strand break repair and pathway choice in pericentromeric heterochromatin depend on the histone demethylase dKDM4A.
- CategoriesFunction, Phenotypes & Variants
- SourceFlyBase: FBgn0041627
The Histone Demethylase KDM5 Is Essential for Larval Growth in <i>Drosophila</i>.
- CategoriesFunction, Phenotypes & Variants
- SourceFlyBase: FBgn0041627
DNA Repair in Drosophila: Mutagens, Models, and Missing Genes.
- CategoryFunction
- SourceFlyBase: FBgn0041627
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles.
- CategoryInteraction
- SourceFlyBase: FBgn0041627
mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster.
- CategorySequences
- SourceFlyBase: FBgn0041627
Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes.
- CategoriesFunction, Interaction
- SourceFlyBase: FBgn0041627
Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes.
- CategoriesFunction, Subcellular Location
- SourceFlyBase: FBgn0041627
Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes.
- CategoryFunction
- SourceFlyBase: FBgn0041627
Phylostratigraphic bias creates spurious patterns of genome evolution.
- CategorySequences
- SourceFlyBase: FBgn0041627