Q8MKK5 · Q8MKK5_DROME
- ProteinGH09271p
- Genekcc
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1028 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- K+(in) + chloride(in) = K+(out) + chloride(out)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | neuronal cell body | |
Cellular Component | plasma membrane | |
Cellular Component | synapse | |
Molecular Function | amino acid transmembrane transporter activity | |
Molecular Function | potassium:chloride symporter activity | |
Biological Process | amino acid transmembrane transport | |
Biological Process | cell volume homeostasis | |
Biological Process | chemical synaptic transmission | |
Biological Process | chloride ion homeostasis | |
Biological Process | chloride transmembrane transport | |
Biological Process | mechanosensory behavior | |
Biological Process | potassium ion homeostasis | |
Biological Process | potassium ion import across plasma membrane | |
Biological Process | response to mechanical stimulus |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ8MKK5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 96-115 | Helical | |||
Transmembrane | 121-142 | Helical | |||
Transmembrane | 181-204 | Helical | |||
Transmembrane | 225-244 | Helical | |||
Transmembrane | 250-270 | Helical | |||
Transmembrane | 380-398 | Helical | |||
Transmembrane | 410-435 | Helical | |||
Transmembrane | 540-561 | Helical | |||
Transmembrane | 573-590 | Helical | |||
Keywords
- Cellular component
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-40 | Disordered | |||
Compositional bias | 7-40 | Basic and acidic residues | |||
Domain | 99-269 | Amino acid permease/ SLC12A | |||
Domain | 362-655 | Amino acid permease/ SLC12A | |||
Domain | 673-786 | SLC12A transporter C-terminal | |||
Domain | 801-1028 | SLC12A transporter C-terminal | |||
Region | 898-950 | Disordered | |||
Compositional bias | 901-921 | Basic and acidic residues | |||
Compositional bias | 930-950 | Basic and acidic residues | |||
Sequence similarities
Belongs to the SLC12A transporter family. K/Cl co-transporter subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,028
- Mass (Da)114,064
- Last updated2002-10-01 v1
- Checksum61BE3310F03CFFE4
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4LGD3 | A0A0B4LGD3_DROME | kcc | 1077 | ||
Q8MLQ5 | Q8MLQ5_DROME | kcc | 1074 | ||
A0A0B4LHE0 | A0A0B4LHE0_DROME | kcc | 1066 | ||
Q9W1G5 | Q9W1G5_DROME | kcc | 1059 | ||
Q9W1G6 | Q9W1G6_DROME | kcc | 1043 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 7-40 | Basic and acidic residues | |||
Compositional bias | 901-921 | Basic and acidic residues | |||
Compositional bias | 930-950 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY118761 EMBL· GenBank· DDBJ | AAM50621.1 EMBL· GenBank· DDBJ | mRNA | ||
AE013599 EMBL· GenBank· DDBJ | AAM68277.1 EMBL· GenBank· DDBJ | Genomic DNA |