Q8MJV0 · MYH1_HORSE

Function

function

Muscle contraction.

Caution

Represents a conventional myosin. This protein should not be confused with the unconventional myosin-1 (MYO1).

Features

Showing features for binding site.

119382004006008001,0001,2001,4001,6001,800
TypeIDPosition(s)Description
Binding site179-186ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmyofibril
Cellular Componentmyosin filament
Cellular Componentmyosin II complex
Molecular Functionactin filament binding
Molecular FunctionATP binding
Molecular Functioncalmodulin binding
Molecular Functionmicrofilament motor activity
Biological Processmuscle contraction

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Myosin-1
  • Alternative names
    • Myosin heavy chain 1
    • Myosin heavy chain 2x (MyHC-2x)
    • Myosin heavy chain, skeletal muscle, adult 1

Gene names

    • Name
      MYH1

Organism names

  • Taxonomic identifier
  • Strain
    • Thoroughbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    Q8MJV0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00002741631-1938Myosin-1
Modified residue64Phosphothreonine
Modified residue69Phosphothreonine
Modified residue130N6,N6,N6-trimethyllysine
Modified residue389Phosphotyrosine
Modified residue419Phosphothreonine
Modified residue424Phosphotyrosine
Modified residue625Phosphoserine
Modified residue756Pros-methylhistidine
Modified residue1091Phosphoserine
Modified residue1095Phosphoserine
Modified residue1161Phosphoserine
Modified residue1236Phosphoserine
Modified residue1240Phosphothreonine
Modified residue1242Phosphoserine
Modified residue1254Phosphothreonine
Modified residue1260Phosphoserine
Modified residue1285Phosphothreonine
Modified residue1291Phosphoserine
Modified residue1302Phosphoserine
Modified residue1305Phosphoserine
Modified residue1463Phosphotyrosine
Modified residue1466Phosphothreonine
Modified residue1473Phosphoserine
Modified residue1491Phosphotyrosine
Modified residue1494Phosphoserine
Modified residue1500Phosphothreonine
Modified residue1513Phosphoserine
Modified residue1516Phosphothreonine
Modified residue1541Phosphoserine
Modified residue1553Phosphoserine
Modified residue1573Phosphoserine
Modified residue1713Phosphoserine
Modified residue1725Phosphoserine
Modified residue1729Phosphothreonine
Modified residue1735Phosphothreonine
Modified residue1738Phosphoserine

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, coiled coil.

Type
IDPosition(s)Description
Domain33-82Myosin N-terminal SH3-like
Domain86-781Myosin motor
Region658-680Actin-binding
Region760-774Actin-binding
Domain784-813IQ
Coiled coil842-1938
Region1124-1146Disordered
Region1152-1171Disordered

Domain

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,938
  • Mass (Da)
    222,941
  • Last updated
    2002-10-01 v1
  • Checksum
    049A535E6D438341
MSSDQEMAIFGEAAPYLRKSEKERIEAQNKPFDAKTSVFVADPKESFVKATVQSREGGKVTAKTEAGATVTVKEDQCFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAVTGEKKKEEPTSGKMQGTLEDQIISANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIEILGFTSDERVSIYKLTGAVMHYGNLKFKQKQREEQAEPDGTEVADKAAYLQGLNSADLLKALCYPRVKVGNEFVTKGQTVEQVYNAVGALAKAVYDKMFLWMVARINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPVKGKPEAHFSLIHYAGTVDYNITGWLDKNKDPLNETVVGLYQKSSVKTLALLFSGPASADAEAGGKKGGKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQIITRTQARCRGFLARVEYQRMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKESLAKAEAKRKELEEKMVALMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEATERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSNLQSKIEDEQALAMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLVNDLTGQRARLQTEAGEYSRQLDEKDSLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSARHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILSEWKHKYEETHAELEASQKESRSLSTELFKVKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKVKKQIEQEKSEIQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHVRVVETMQTMLDAEIRSRNDAIRIKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQLQGEMEDIVQEAHNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRDLEGEVESEQKRNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQSKVKAYKRQAEEAEEQSNVNLSKFRKIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q2GYL4A0A3Q2GYL4_HORSEMYH21937
A0A3Q2GZ82A0A3Q2GZ82_HORSEMYH21939
F6QLB5F6QLB5_HORSEMYH22045
A0A9L0RDD8A0A9L0RDD8_HORSEMYH22537
A0A9R8NQP3A0A9R8NQP3_HORSEMYH21910
A0A3Q2HB31A0A3Q2HB31_HORSEMYH22683

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB088366
EMBL· GenBank· DDBJ
BAC05680.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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