Q8MJV0 · MYH1_HORSE
- ProteinMyosin-1
- GeneMYH1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1938 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Muscle contraction.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 179-186 | ATP (UniProtKB | ChEBI) | |||
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | myofibril | |
Cellular Component | myosin filament | |
Cellular Component | myosin II complex | |
Molecular Function | actin filament binding | |
Molecular Function | ATP binding | |
Molecular Function | calmodulin binding | |
Molecular Function | microfilament motor activity | |
Biological Process | muscle contraction |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMyosin-1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus
Accessions
- Primary accessionQ8MJV0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Thick filaments of the myofibrils.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000274163 | 1-1938 | Myosin-1 | ||
Modified residue | 64 | Phosphothreonine | |||
Modified residue | 69 | Phosphothreonine | |||
Modified residue | 130 | N6,N6,N6-trimethyllysine | |||
Modified residue | 389 | Phosphotyrosine | |||
Modified residue | 419 | Phosphothreonine | |||
Modified residue | 424 | Phosphotyrosine | |||
Modified residue | 625 | Phosphoserine | |||
Modified residue | 756 | Pros-methylhistidine | |||
Modified residue | 1091 | Phosphoserine | |||
Modified residue | 1095 | Phosphoserine | |||
Modified residue | 1161 | Phosphoserine | |||
Modified residue | 1236 | Phosphoserine | |||
Modified residue | 1240 | Phosphothreonine | |||
Modified residue | 1242 | Phosphoserine | |||
Modified residue | 1254 | Phosphothreonine | |||
Modified residue | 1260 | Phosphoserine | |||
Modified residue | 1285 | Phosphothreonine | |||
Modified residue | 1291 | Phosphoserine | |||
Modified residue | 1302 | Phosphoserine | |||
Modified residue | 1305 | Phosphoserine | |||
Modified residue | 1463 | Phosphotyrosine | |||
Modified residue | 1466 | Phosphothreonine | |||
Modified residue | 1473 | Phosphoserine | |||
Modified residue | 1491 | Phosphotyrosine | |||
Modified residue | 1494 | Phosphoserine | |||
Modified residue | 1500 | Phosphothreonine | |||
Modified residue | 1513 | Phosphoserine | |||
Modified residue | 1516 | Phosphothreonine | |||
Modified residue | 1541 | Phosphoserine | |||
Modified residue | 1553 | Phosphoserine | |||
Modified residue | 1573 | Phosphoserine | |||
Modified residue | 1713 | Phosphoserine | |||
Modified residue | 1725 | Phosphoserine | |||
Modified residue | 1729 | Phosphothreonine | |||
Modified residue | 1735 | Phosphothreonine | |||
Modified residue | 1738 | Phosphoserine | |||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 33-82 | Myosin N-terminal SH3-like | |||
Domain | 86-781 | Myosin motor | |||
Region | 658-680 | Actin-binding | |||
Region | 760-774 | Actin-binding | |||
Domain | 784-813 | IQ | |||
Coiled coil | 842-1938 | ||||
Region | 1124-1146 | Disordered | |||
Region | 1152-1171 | Disordered | |||
Domain
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
Sequence similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,938
- Mass (Da)222,941
- Last updated2002-10-01 v1
- Checksum049A535E6D438341
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A3Q2GYL4 | A0A3Q2GYL4_HORSE | MYH2 | 1937 | ||
A0A3Q2GZ82 | A0A3Q2GZ82_HORSE | MYH2 | 1939 | ||
F6QLB5 | F6QLB5_HORSE | MYH2 | 2045 | ||
A0A9L0RDD8 | A0A9L0RDD8_HORSE | MYH2 | 2537 | ||
A0A9R8NQP3 | A0A9R8NQP3_HORSE | MYH2 | 1910 | ||
A0A3Q2HB31 | A0A3Q2HB31_HORSE | MYH2 | 2683 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB088366 EMBL· GenBank· DDBJ | BAC05680.1 EMBL· GenBank· DDBJ | mRNA |