Q8LVA7 · Q8LVA7_HYPTH

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Encoded on

  • Mitochondrion

Organism names

Accessions

  • Primary accession
    Q8LVA7

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane51-76Helical
Transmembrane88-115Helical
Transmembrane148-168Helical
Transmembrane175-196Helical
Transmembrane208-231Helical
Transmembrane243-264Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-27
ChainPRO_500771408328-268Cytochrome c oxidase subunit 1

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-268Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    268
  • Mass (Da)
    28,933
  • Last updated
    2002-10-01 v1
  • Checksum
    619BD57684152FB7
RMNNLSFWLLPPSLVLLLLSSLNEVGAGTGWTIYPPLSGIIAHAGVSVDMAIFSLHLAGASSIMGAINFITTIINMRLKGVSMEKVPLFVWSVLITAVLLLLSLPVLAGAITMLLTDRNFNTSFFDPAGGGDPILFQHLFWFFGHPEVYILILPGFGIVSHIISYSAGKREPFGVLGMIYAMAGIGGMGFVVWAHHMFSVGMDVDTRAYFTAATMVIAVPTGIKIFSWMATLHGAYYKFNSSLLWSMGFIFLFTLGGITGVVLANSSL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue268

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY102064
EMBL· GenBank· DDBJ
AAM52090.1
EMBL· GenBank· DDBJ
Genomic DNA
AY102065
EMBL· GenBank· DDBJ
AAM52091.1
EMBL· GenBank· DDBJ
Genomic DNA
AY102066
EMBL· GenBank· DDBJ
AAM52092.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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