Q8LFT2 · DRP3B_ARATH
- ProteinDynamin-related protein 3B
- GeneDRP3B
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids780 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in the control of mitochondrial and peroxisomal division and morphology.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Cellular Component | microtubule | |
Cellular Component | mitochondrion | |
Cellular Component | peroxisome | |
Molecular Function | GTP binding | |
Molecular Function | GTPase activity | |
Molecular Function | microtubule binding | |
Biological Process | cell division | |
Biological Process | mitochondrial fission | |
Biological Process | peroxisome fission |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameDynamin-related protein 3B
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8LFT2
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Reduced plant growth. Increase in the size of peroxisomes and decrease in the number of peroxisomes per cell.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 56 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylserine | ||||
Sequence: S | ||||||
Chain | PRO_0000206585 | 2-780 | Dynamin-related protein 3B | |||
Sequence: SVDDLPPSSASAVTPLGSSVIPIVNKLQDIFAQLGSQSTIALPQVAVVGSQSSGKSSVLEALVGRDFLPRGNDICTRRPLRLQLVQTKPSSDGGSDEEWGEFLHHDPVRRIYDFSEIRREIEAETNRVSGENKGVSDIPIGLKIFSPNVLDISLVDLPGITKVPVGDQPSDIEARIRTMILTYIKEPSCLILAVSPANTDLANSDALQIAGNADPDGHRTIGVITKLDIMDRGTDARNHLLGKTIPLRLGYVGVVNRSQEDILMNRSIKDALVAEEKFFRSRPVYSGLTDRLGVPQLAKKLNQVLVQHIKALLPSLKSRINNALFATAKEYESYGDITESRGGQGALLLSFITKYCEAYSSTLEGKSKEMSTSELSGGARILYIFQSVFVKSLEEVDPCEDLTADDIRTAIQNATGPRSALFVPDVPFEVLVRRQISRLLDPSLQCARFIFDELVKISHQCMMKELQRFPVLQKRMDEVIGNFLREGLEPSQAMIRDLIEMEMDYINTSHPNFIGGTKAVEQAMQTVKSSRIPHPVARPRDTVEPERTASSGSQIKTRSFLGRQANGIITDQAVPTAADAERPAPAGSTSWSGFSSIFRGSDGQAAAKNNLLNKPFSETTQEVYQNLSTIYLKEPPTILKSSETHSEQESVEIEITKLLLKSYYDIVRKNVEDLVPKAIMHFLVNYTKRELHNVFIEKLYRENLIEELLKEPDELAIKRKRTQETLRILQQANRTLDELPLEAESVERGYKIGSEAKHEELPGTRRSRTETNGNGRLHM |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Interacts with ARC5 on peroxisomes and ELM1 on mitochondria.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8LFT2 | DRP3A Q8S944 | 6 | EBI-2265511, EBI-2265428 | |
BINARY | Q8LFT2 | LSD1 P94077 | 3 | EBI-2265511, EBI-5849461 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 40-315 | Dynamin-type G | ||||
Sequence: TIALPQVAVVGSQSSGKSSVLEALVGRDFLPRGNDICTRRPLRLQLVQTKPSSDGGSDEEWGEFLHHDPVRRIYDFSEIRREIEAETNRVSGENKGVSDIPIGLKIFSPNVLDISLVDLPGITKVPVGDQPSDIEARIRTMILTYIKEPSCLILAVSPANTDLANSDALQIAGNADPDGHRTIGVITKLDIMDRGTDARNHLLGKTIPLRLGYVGVVNRSQEDILMNRSIKDALVAEEKFFRSRPVYSGLTDRLGVPQLAKKLNQVLVQHIKALLP | ||||||
Region | 50-57 | G1 motif | ||||
Sequence: GSQSSGKS | ||||||
Region | 76-78 | G2 motif | ||||
Sequence: CTR | ||||||
Region | 157-160 | G3 motif | ||||
Sequence: DLPG | ||||||
Region | 226-229 | G4 motif | ||||
Sequence: TKLD | ||||||
Region | 256-259 | G5 motif | ||||
Sequence: VNRS | ||||||
Region | 536-558 | Disordered | ||||
Sequence: PVARPRDTVEPERTASSGSQIKT | ||||||
Region | 573-592 | Disordered | ||||
Sequence: QAVPTAADAERPAPAGSTSW | ||||||
Domain | 654-745 | GED | ||||
Sequence: IEITKLLLKSYYDIVRKNVEDLVPKAIMHFLVNYTKRELHNVFIEKLYRENLIEELLKEPDELAIKRKRTQETLRILQQANRTLDELPLEAE | ||||||
Region | 753-780 | Disordered | ||||
Sequence: IGSEAKHEELPGTRRSRTETNGNGRLHM |
Sequence similarities
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8LFT2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length780
- Mass (Da)86,644
- Last updated2005-02-01 v2
- ChecksumCB50374F3F428714
Q8LFT2-2
- Name2
- NoteMay be due to an intron retention.
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8AXZ9 | A0A1P8AXZ9_ARATH | At2g14080 | 1082 | ||
A0A1P8AX46 | A0A1P8AX46_ARATH | DRP3B | 737 | ||
F4IFF6 | F4IFF6_ARATH | At2g14080 | 1215 | ||
F4IFG1 | F4IFG1_ARATH | DRP3B | 780 | ||
F4IFG2 | F4IFG2_ARATH | DRP3B | 809 |
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 96 | in Ref. 1; BAB85645 | ||||
Sequence: S → P | ||||||
Sequence conflict | 204 | in Ref. 4; AAM20619 | ||||
Sequence: N → S | ||||||
Alternative sequence | VSP_012757 | 343-370 | in isoform 2 | |||
Sequence: GGQGALLLSFITKYCEAYSSTLEGKSKE → VCGFWPVLALYIPSILNDGIAICFFCVV | ||||||
Sequence conflict | 369 | In isoform Q8LFT2-2; in Ref. 5; AAM61220 | ||||
Sequence: V → I | ||||||
Alternative sequence | VSP_012758 | 371-780 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB072375 EMBL· GenBank· DDBJ | BAB85645.1 EMBL· GenBank· DDBJ | mRNA | ||
AC007197 EMBL· GenBank· DDBJ | AAM15450.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC007197 EMBL· GenBank· DDBJ | AAD25856.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC06282.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY099768 EMBL· GenBank· DDBJ | AAM20619.1 EMBL· GenBank· DDBJ | mRNA | ||
AY084657 EMBL· GenBank· DDBJ | AAM61220.1 EMBL· GenBank· DDBJ | mRNA |