Q8LBZ7 · SDHB1_ARATH
- ProteinSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial
- GeneSDH2-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids279 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Catalytic activity
- a quinone + succinate = fumarate + a quinol
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 [2Fe-2S] cluster.
Note: Binds 1 [3Fe-4S] cluster.
Note: Binds 1 [4Fe-4S] cluster.
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 102 | [2Fe-2S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 107 | [2Fe-2S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 122 | [2Fe-2S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 194 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 197 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 200 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 204 | [3Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 209 | a ubiquinone (UniProtKB | ChEBI); ligand shared with SdhD subunit | ||||
Sequence: W | ||||||
Binding site | 251 | [3Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 257 | [3Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 261 | [4Fe-4S] cluster (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrial inner membrane | |
Cellular Component | mitochondrion | |
Cellular Component | respiratory chain complex II (succinate dehydrogenase) | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | 3 iron, 4 sulfur cluster binding | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | electron transfer activity | |
Molecular Function | succinate dehydrogenase (quinone) activity | |
Molecular Function | succinate dehydrogenase activity | |
Molecular Function | zinc ion binding | |
Biological Process | mitochondrial electron transport, succinate to ubiquinone | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8LBZ7
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transit peptide | 1-28 | Mitochondrion | ||||
Sequence: MASGLIGRLVGTKPSKLATAARLIPARW | ||||||
Chain | PRO_0000247595 | 29-279 | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial | |||
Sequence: TSTGAEAETKASSGGGRGSNLKTFQIYRWNPDNPGKPELQNYQIDLKDCGPMVLDALIKIKNEMDPSLTFRRSCREGICGSCAMNIDGCNGLACLTKIQDEASETTITPLPHMFVIKDLVVDMTNFYNQYKSIEPWLKRKTPASVPAKEILQSKKDRAKLDGMYECILCACCSTSCPSYWWNPESYLGPAALLHANRWISDSRDEYTKERLEAIDDEFKLYRCHTILNCARACPKGLNPGKQITHIKQLQR |
Proteomic databases
Expression
Tissue specificity
Ubiquitous. Preferentially expressed in flowers and inflorescences.
Developmental stage
Expressed in floral meristems and sex organ primordia at early stages of development. Later expressed in anthers, particularly in the tapetum, pollen mother cells, and microspores.
Gene expression databases
Interaction
Subunit
Component of complex II composed of eight subunits in plants: four classical SDH subunits SDH1, SDH2, SDH3 and SDH4 (a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.), as well as four subunits unknown in mitochondria from bacteria and heterotrophic eukaryotes.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 52-141 | 2Fe-2S ferredoxin-type | ||||
Sequence: FQIYRWNPDNPGKPELQNYQIDLKDCGPMVLDALIKIKNEMDPSLTFRRSCREGICGSCAMNIDGCNGLACLTKIQDEASETTITPLPHM | ||||||
Domain | 184-214 | 4Fe-4S ferredoxin-type | ||||
Sequence: DRAKLDGMYECILCACCSTSCPSYWWNPESY |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length279
- Mass (Da)31,171
- Last updated2006-07-25 v2
- ChecksumADA885EC59A3EA36
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 20 | in Ref. 1; CAC19855 and 6; AAM63946 | ||||
Sequence: A → V | ||||||
Sequence conflict | 26 | in Ref. 1; CAC19855 and 6; AAM63946 | ||||
Sequence: A → V | ||||||
Sequence conflict | 200 | in Ref. 6; AAM63946 | ||||
Sequence: C → F |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ278910 EMBL· GenBank· DDBJ | CAC19855.1 EMBL· GenBank· DDBJ | mRNA | ||
AB024028 EMBL· GenBank· DDBJ | BAA95713.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE77309.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE77310.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY035013 EMBL· GenBank· DDBJ | AAK59518.1 EMBL· GenBank· DDBJ | mRNA | ||
AY063053 EMBL· GenBank· DDBJ | AAL34227.1 EMBL· GenBank· DDBJ | mRNA | ||
AY924777 EMBL· GenBank· DDBJ | AAX23852.1 EMBL· GenBank· DDBJ | mRNA | ||
AY086901 EMBL· GenBank· DDBJ | AAM63946.1 EMBL· GenBank· DDBJ | mRNA |