Q8L8Y3 · PCEP1_ARATH
- ProteinPrecursor of CEP1
- GeneCEP1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Extracellular signaling peptide that represses, in a dose-dependent manner, primary root growth rate and lateral root elongation by inhibiting both cell division in meristems and cell growth in elongation zones. Prevents also slightly growth of above-ground parts (PubMed:18315543).
Regulates systemic nitrogen (N)-demand signaling. Mediates systemic up-regulation of genes involved in N uptake and assimilation pathways (e.g. NRT1.1, NRT2.1 and NRT3.1) (PubMed:25324386).
Regulates systemic nitrogen (N)-demand signaling. Mediates systemic up-regulation of genes involved in N uptake and assimilation pathways (e.g. NRT1.1, NRT2.1 and NRT3.1) (PubMed:25324386).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | apoplast | |
Cellular Component | extracellular space | |
Molecular Function | hormone activity | |
Biological Process | cell surface receptor signaling pathway | |
Biological Process | cellular response to ammonium ion | |
Biological Process | cellular response to nitrogen starvation | |
Biological Process | lateral root development | |
Biological Process | negative regulation of cell division | |
Biological Process | negative regulation of cell growth | |
Biological Process | nitrate import | |
Biological Process | nitrogen utilization | |
Biological Process | photoperiodism, flowering | |
Biological Process | regulation of root development | |
Biological Process | response to auxin | |
Biological Process | response to nitrate starvation | |
Biological Process | response to osmotic stress | |
Biological Process | response to salt stress | |
Biological Process | root development |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended namePrecursor of CEP1
- Short namesPCEP1
- Cleaved into 1 chains
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8L8Y3
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
C-terminally encoded peptide 1
Note: Accumulates in xylem sap under nitrogen (N)-starved conditions.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, propeptide, peptide, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-28 | |||||
Sequence: MGMSNRSVSTSIFFLALVVLHGIQDTEE | ||||||
Propeptide | PRO_0000439960 | 29-71 | ||||
Sequence: RHLKTTSLEIEGIYKKTEAEHPSIVVTYTRRGVLQKEVIAHPT | ||||||
Peptide | PRO_0000439961 | 72-86 | C-terminally encoded peptide 1 | |||
Sequence: DFRPTNPGNSPGVGH | ||||||
Modified residue | 75 | Hydroxyproline; partial | ||||
Sequence: P | ||||||
Modified residue | 78 | Hydroxyproline | ||||
Sequence: P | ||||||
Modified residue | 82 | Hydroxyproline; partial | ||||
Sequence: P | ||||||
Propeptide | PRO_0000439962 | 87-91 | ||||
Sequence: SNGRH |
Post-translational modification
The mature small signaling peptide is generated by proteolytic processing of the longer precursor.
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
Mainly expressed in the lateral root primordia (PubMed:18315543).
Also present in the shoot apical meristem (SAM) (PubMed:18315543, PubMed:24179095).
Detected in the primary root apical meristem, at the root-hypocotyl junction, roots, leaves (in the small dentations at the leaf margin), siliques and flowers (PubMed:24179095).
Also present in the shoot apical meristem (SAM) (PubMed:18315543, PubMed:24179095).
Detected in the primary root apical meristem, at the root-hypocotyl junction, roots, leaves (in the small dentations at the leaf margin), siliques and flowers (PubMed:24179095).
Induction
Induced by auxin and nitrogen (N) (PubMed:24179095).
Induced in shoots in response to nitrogen and nitrate starvation (PubMed:24179096, PubMed:25324386).
Accumulates also under osmotic stress (e.g. mannitol and NaCl) (PubMed:24179096).
Induced in shoots in response to nitrogen and nitrate starvation (PubMed:24179096, PubMed:25324386).
Accumulates also under osmotic stress (e.g. mannitol and NaCl) (PubMed:24179096).
Developmental stage
In young seedlings, only observed in lateral root primordia, first in the core region at stage VI, in which cells of outer layer 2 undergo a periclinal division, creating a new internal layer (PubMed:18315543, PubMed:24179095).
Maximum levels are reached at the emergence stage, and steeply decrease after elongation of lateral roots, except for residual expression in the region of vascular connection. In two weeks old seedlings, also present in the shoot apical mersitem (SAM) (PubMed:18315543).
Accumulates during flower development and during lateral root development. In flowers, present in the gynoecium (PubMed:24179095).
Repressed upon floral induction (PubMed:14573523).
Maximum levels are reached at the emergence stage, and steeply decrease after elongation of lateral roots, except for residual expression in the region of vascular connection. In two weeks old seedlings, also present in the shoot apical mersitem (SAM) (PubMed:18315543).
Accumulates during flower development and during lateral root development. In flowers, present in the gynoecium (PubMed:24179095).
Repressed upon floral induction (PubMed:14573523).
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 69-91 | Disordered | ||||
Sequence: HPTDFRPTNPGNSPGVGHSNGRH | ||||||
Compositional bias | 74-91 | Polar residues | ||||
Sequence: RPTNPGNSPGVGHSNGRH |
Sequence similarities
Belongs to the C-terminally encoded plant signaling peptide (CEP) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length91
- Mass (Da)10,080
- Last updated2002-10-01 v1
- Checksum0F9B56B9AEA2B559
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 74-91 | Polar residues | ||||
Sequence: RPTNPGNSPGVGHSNGRH |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB333778 EMBL· GenBank· DDBJ | BAG34615.1 EMBL· GenBank· DDBJ | mRNA | ||
AC007519 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CP002684 EMBL· GenBank· DDBJ | AEE32172.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ446335 EMBL· GenBank· DDBJ | ABE65696.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ652886 EMBL· GenBank· DDBJ | ABK28436.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AY088738 EMBL· GenBank· DDBJ | AAM67056.1 EMBL· GenBank· DDBJ | mRNA |