Q8L6Z7 · EXO1_ARATH

Function

function

Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity).

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.

Features

Showing features for binding site.

1735100200300400500600700
TypeIDPosition(s)Description
Binding site30Mg2+ 1 (UniProtKB | ChEBI)
Binding site78Mg2+ 1 (UniProtKB | ChEBI)
Binding site150Mg2+ 1 (UniProtKB | ChEBI)
Binding site152Mg2+ 1 (UniProtKB | ChEBI)
Binding site171Mg2+ 2 (UniProtKB | ChEBI)
Binding site173Mg2+ 2 (UniProtKB | ChEBI)
Binding site226Mg2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Function5'-3' DNA exonuclease activity
Molecular FunctionDNA binding
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Molecular FunctionSUMO binding
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      EXO1
    • ORF names
      F15D2.37
    • Ordered locus names
      At1g29630

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q8L6Z7
  • Secondary accessions
    • Q9C7N8

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003156201-735Exonuclease 1

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region1-99N-domain
Region138-230I-domain
Region391-456Disordered
Compositional bias416-425Polar residues
Compositional bias438-456Basic and acidic residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8L6Z7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    735
  • Mass (Da)
    82,249
  • Last updated
    2008-01-15 v2
  • MD5 Checksum
    53A691257DA51E35DB584326EF6C2BDE
MGIQGLLPLLKSIMVPIHIKELEGCIVAVDTYSWLHKGALSCSRELCKGLPTKRHIQYCMHRVNLLRHHGVKPIMVFDGGPLPMKLEQENKRARSRKENLARALEHEANGNSSAAYECYSKAVDISPSIAHELIQVLRQENVDYVVAPYEADAQMAFLAITKQVDAIITEDSDLIPFGCLRIIFKMDKFGHGVEFQASKLPKNKDLSLSGFSSQMLLEMCILSGCDYLQSLPGMGLKRAHALITKFKSYDRVIKHLKYSTVSVPPLYEESFKRALLTFKHQRVYDPNAEDIIHLCDISDNLGEDSDFVGPSMPQDIAKGIALGQLDPFTQLPFQAESVTPKLAVDDISRPKSFKPETVKKKLDLPVQKNLLTKYFCFASVEAKRKFKAPRISPMSLTPTDESPSIPDDNTPDLDALSSQTTNESPVYSLGENPCVSEVAEKRDSPDDDAVERNHKDLHHKYCEREVDRPKSDSLKVIVRSKYFKQKQEDKSLKQSIPCLNDCSVIGQRKAVKTVINMSSASKREESHRAIATSPCLHHDRIYNDHEDAKEASFSAMNEVAERTINTHKINHQINEEEQNPSVEIPSAFSTPENVIPLSSIAIDSCHGVATGKRKLDSDENLHKENLKSKHMRMDETDTALNAETPLETDDVEKFGSNISHIGHYSEIAEKSVERFVSAISSFKYSGTGSRASGLRAPLKDIRNTCPSKGLSLKPDISKFGYASSNRHMVTKSRRM

Q8L6Z7-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
B3H7B3B3H7B3_ARATHAt1g29630581

Sequence caution

The sequence AAG51751.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for alternative sequence, sequence conflict, compositional bias.

Type
IDPosition(s)Description
Alternative sequenceVSP_030585182-251in isoform 2
Sequence conflict377in Ref. 3; AAM98196
Compositional bias416-425Polar residues
Compositional bias438-456Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC068667
EMBL· GenBank· DDBJ
AAG51751.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002684
EMBL· GenBank· DDBJ
AEE31111.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE31112.1
EMBL· GenBank· DDBJ
Genomic DNA
AY140055
EMBL· GenBank· DDBJ
AAM98196.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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