Q8L6Z7 · EXO1_ARATH
- ProteinExonuclease 1
- GeneEXO1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids735 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Putative 5'->3' double-stranded DNA exonuclease which may also contain a cryptic 3'->5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR) (By similarity).
Cofactor
Note: Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 30 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 78 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 150 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 152 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 171 | Mg2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 173 | Mg2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 226 | Mg2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | 5'-3' DNA exonuclease activity | |
Molecular Function | DNA binding | |
Molecular Function | endonuclease activity | |
Molecular Function | metal ion binding | |
Molecular Function | SUMO binding | |
Biological Process | DNA repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameExonuclease 1
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8L6Z7
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000315620 | 1-735 | Exonuclease 1 | ||
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-99 | N-domain | |||
Region | 138-230 | I-domain | |||
Region | 391-456 | Disordered | |||
Compositional bias | 416-425 | Polar residues | |||
Compositional bias | 438-456 | Basic and acidic residues | |||
Sequence similarities
Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8L6Z7-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length735
- Mass (Da)82,249
- Last updated2008-01-15 v2
- MD5 Checksum53A691257DA51E35DB584326EF6C2BDE
Q8L6Z7-2
- Name2
- Differences from canonical
- 182-251: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
B3H7B3 | B3H7B3_ARATH | At1g29630 | 581 |
Sequence caution
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_030585 | 182-251 | in isoform 2 | ||
Sequence conflict | 377 | in Ref. 3; AAM98196 | |||
Compositional bias | 416-425 | Polar residues | |||
Compositional bias | 438-456 | Basic and acidic residues | |||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC068667 EMBL· GenBank· DDBJ | AAG51751.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002684 EMBL· GenBank· DDBJ | AEE31111.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE31112.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY140055 EMBL· GenBank· DDBJ | AAM98196.1 EMBL· GenBank· DDBJ | mRNA |