Q8L500 · APRR9_ARATH
- ProteinTwo-component response regulator-like APRR9
- GeneAPRR9
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids468 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Transcriptional repressor of CCA1 and LHY, and positive regulator of LWD1 and LWD2 expression. Controls photoperiodic flowering response and temperature compensation. Involved in the positive and negative feedback loops of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. Regulated at the transcriptional level by a corepressor complex consisting of ELF4, ELF3, and LUX. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock.
Miscellaneous
Regulated at the level of mRNA maturation and alternative splicing by SKIP (PubMed:22942380) and PRMT5 (PubMed:20962777).
The expression of APRR9, APRR7, and APRR5 requires the presence of LWD1 and/or LWD2, indicating the existence of a positive feedback loop within the circadian clock (PubMed:21357491).
The expression of APRR9, APRR7, and APRR5 requires the presence of LWD1 and/or LWD2, indicating the existence of a positive feedback loop within the circadian clock (PubMed:21357491).
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Biological Process | circadian rhythm | |
Biological Process | cytokinin-activated signaling pathway | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | phosphorelay signal transduction system | |
Biological Process | red or far-red light signaling pathway | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTwo-component response regulator-like APRR9
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8L500
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000081441 | 1-468 | Two-component response regulator-like APRR9 | |||
Sequence: MGEIVVLSSDDGMETIKNRVKSSEVVQWEKYLPKTVLRVLLVESDYSTRQIITALLRKCCYKVVAVSDGLAAWEVLKEKSHNIDLILTELDLPSISGFALLALVMEHEACKNIPVIMMSSQDSIKMVLKCMLRGAADYLIKPMRKNELKNLWQHVWRRLTLRDDPTAHAQSLPASQHNLEDTDETCEDSRYHSDQGSGAQAINYNGHNKLMENGKSVDERDEFKETFDVTMDLIGGIDKRPDSIYKDKSRDECVGPELGLSLKRSCSVSFENQDESKHQKLSLSDASAFSRFEESKSAEKAVVALEESTSGEPKTPTESHEKLRKVTSDQGSATTSSNQENIGSSSVSFRNQVLQSTVTNQKQDSPIPVESNREKAASKEVEAGSQSTNEGIAGQSSSTEKPKEEESAKQRWSRSQREAALMKFRLKRKDRCFDKKVRYQSRKKLAEQRPRVKGQFVRTVNSDASTKS |
Post-translational modification
Phosphorylated. Phosphorylation varies throughout the diurnal cycle.
Keywords
- PTM
Proteomic databases
Expression
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8L500 | BBX18 Q9SJU5 | 3 | EBI-7920168, EBI-15192077 | |
BINARY | Q8L500 | BBX19 C0SVM5 | 3 | EBI-7920168, EBI-4430993 | |
BINARY | Q8L500 | NFYC2 Q8LCG7 | 3 | EBI-7920168, EBI-2125983 | |
BINARY | Q8L500 | NFYC4 Q9FMV5 | 3 | EBI-7920168, EBI-2466018 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 38-156 | Response regulatory | ||||
Sequence: RVLLVESDYSTRQIITALLRKCCYKVVAVSDGLAAWEVLKEKSHNIDLILTELDLPSISGFALLALVMEHEACKNIPVIMMSSQDSIKMVLKCMLRGAADYLIKPMRKNELKNLWQHVW | ||||||
Region | 168-203 | Disordered | ||||
Sequence: HAQSLPASQHNLEDTDETCEDSRYHSDQGSGAQAIN | ||||||
Region | 302-416 | Disordered | ||||
Sequence: VVALEESTSGEPKTPTESHEKLRKVTSDQGSATTSSNQENIGSSSVSFRNQVLQSTVTNQKQDSPIPVESNREKAASKEVEAGSQSTNEGIAGQSSSTEKPKEEESAKQRWSRSQ | ||||||
Compositional bias | 313-327 | Basic and acidic residues | ||||
Sequence: PKTPTESHEKLRKVT | ||||||
Compositional bias | 328-367 | Polar residues | ||||
Sequence: SDQGSATTSSNQENIGSSSVSFRNQVLQSTVTNQKQDSPI | ||||||
Compositional bias | 381-398 | Polar residues | ||||
Sequence: VEAGSQSTNEGIAGQSSS | ||||||
Compositional bias | 399-416 | Basic and acidic residues | ||||
Sequence: TEKPKEEESAKQRWSRSQ | ||||||
Domain | 417-459 | CCT | ||||
Sequence: REAALMKFRLKRKDRCFDKKVRYQSRKKLAEQRPRVKGQFVRT | ||||||
Region | 442-468 | Disordered | ||||
Sequence: RKKLAEQRPRVKGQFVRTVNSDASTKS |
Sequence similarities
Belongs to the ARR-like family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
This entry describes 1 isoforms produced by Alternative splicing. A number of isoforms are produced. According to EST sequences.
Q8L500-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length468
- Mass (Da)52,565
- Last updated2004-09-27 v2
- Checksum19D6C9571CA77A40
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8B286 | A0A1P8B286_ARATH | PRR9 | 444 | ||
A0A1P8B243 | A0A1P8B243_ARATH | PRR9 | 311 | ||
F4IJA1 | F4IJA1_ARATH | PRR9 | 351 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 313-327 | Basic and acidic residues | ||||
Sequence: PKTPTESHEKLRKVT | ||||||
Compositional bias | 328-367 | Polar residues | ||||
Sequence: SDQGSATTSSNQENIGSSSVSFRNQVLQSTVTNQKQDSPI | ||||||
Compositional bias | 381-398 | Polar residues | ||||
Sequence: VEAGSQSTNEGIAGQSSS | ||||||
Compositional bias | 399-416 | Basic and acidic residues | ||||
Sequence: TEKPKEEESAKQRWSRSQ |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB046953 EMBL· GenBank· DDBJ | BAB13741.1 EMBL· GenBank· DDBJ | mRNA | ||
AF272040 EMBL· GenBank· DDBJ | AAF86253.1 EMBL· GenBank· DDBJ | mRNA | ||
AC005310 EMBL· GenBank· DDBJ | AAC33497.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC10754.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY099676 EMBL· GenBank· DDBJ | AAM20527.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AY128856 EMBL· GenBank· DDBJ | AAM91256.1 EMBL· GenBank· DDBJ | mRNA | Frameshift |